Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

• Published in: Inflammation research Vol. 64; no. 12; pp. 993 - 1003
• Main Authors: Fattori, Victor, Pinho-Ribeiro, Felipe A., Borghi, Sergio M., Alves-Filho, José C., Cunha, Thiago M., Cunha, Fernando Q., Casagrande, Rubia, Verri, Waldiceu A.
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01.12.2015
• Subjects: Allergology; Animals; Antioxidants - administration & dosage; Antioxidants - pharmacology; Biomedical and Life Sciences; Biomedicine; Curcumin - administration & dosage; Curcumin - pharmacology; Cytokines - biosynthesis; Dermatology; Heme Oxygenase-1 - biosynthesis; Hyperalgesia - chemically induced; Hyperalgesia - prevention & control; Immunology; Injections, Subcutaneous; Leukocytes - drug effects; Male; Membrane Glycoproteins - biosynthesis; Membrane Glycoproteins - genetics; Mice; NADPH Oxidase 2; NADPH Oxidases - biosynthesis; NADPH Oxidases - genetics; Neurology; NF-E2-Related Factor 2 - biosynthesis; NF-E2-Related Factor 2 - drug effects; NF-E2-Related Factor 2 - genetics; NF-kappa B - antagonists & inhibitors; Original Research Paper; Oxidants - toxicity; Oxidative Stress - drug effects; Oxides - chemistry; Pain - chemically induced; Pain - psychology; Pharmacology/Toxicology; Potassium Compounds - chemistry; Rheumatology; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Superoxides - antagonists & inhibitors; Superoxides - toxicity; NF-κB; Superoxide anion; Curcumin; Pain; Nrf2; IL-10

Objective This study aimed at evaluating the activity of curcumin in superoxide anion-induced pain-like behavior and leukocyte recruitment in mice. Treatment Administration of curcumin 10 mg/kg subcutaneously 1 h before stimulus. Methods KO 2 was used as superoxide anion donor. Overt pain-like behav...