Phospho-histone-H3 immunostaining for pulmonary carcinoids: impact on clinical appraisal, interobserver correlation, and diagnostic processing efficiency

• Published in: Human pathology Vol. 106; pp. 74 - 81
• Main Authors: Laflamme, Philippe, Mansoori, Babak K., Sazanova, Olga, Orain, Michèle, Couture, Christian, Simard, Serge, Trahan, Sylvain, Manem, Venkata, Joubert, Philippe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020; Elsevier Limited
• Subjects: Adult; Aged; Biomarkers, Tumor - analysis; Carcinoid; Carcinoid Tumor - chemistry; Carcinoid Tumor - pathology; Carcinoid Tumor - surgery; Classification; Female; Histones - analysis; Humans; Immunohistochemistry; Index; Lung; Lung cancer; Lung Neoplasms - chemistry; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lymphatic system; Male; Medical prognosis; Metastasis; Methods; Middle Aged; Mitosis; Mitotic Index; Neuroendocrine tumors; Observer Variation; Patients; Phospho-histone-H3; Phosphorylation; Predictive Value of Tests; Reproducibility of Results; Stains & staining; Carcinoid; Index; Phospho-histone-H3; Mitosis; Lung

Lung carcinoid tumors are classified as either typical or atypical based on the presence of necrosis and the maximum mitotic count per 2 mm2 area. Determining the mitotic count, which is manually conducted on slides stained with hematoxylin and eosin (HE), is time-consuming and subject to high inter...