Fetal development of baroreflex sensitivity: The chicken embryo as a case model
Abstract The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late in...
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| Published in | Respiratory physiology & neurobiology Vol. 178; no. 1; pp. 75 - 83 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
31.08.2011
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| Abstract | Abstract The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late incubation using a novel method that measured changes in heart rate during spontaneous fluctuations in blood pressure. Our results suggest that a baroreflex is already functional at d17 with no indication of further maturation in terms of sensitivity (gain at 17 d was 52.9 ± 8.3 and at 20 d 69.5 ± 16.2 ms kPa−1 ). The physiological relevance of these values is shown using data surrogation methods. Although the results contrast with the progressive baroreflex maturation indicated by the pharmacological method, we sustain that both methods provide information on baroreflex regulation. While the spontaneous method evaluates truly physiological (but small) pressure changes, the pharmacological method provides a more consistent and repetitive challenge for the reflex that requires a different recruitment of baroreflex effectors. |
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| AbstractList | The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late incubation using a novel method that measured changes in heart rate during spontaneous fluctuations in blood pressure. Our results suggest that a baroreflex is already functional at d17 with no indication of further maturation in terms of sensitivity (gain at 17 d was 52.9±8.3 and at 20 d 69.5±16.2 ms kPa(-1)). The physiological relevance of these values is shown using data surrogation methods. Although the results contrast with the progressive baroreflex maturation indicated by the pharmacological method, we sustain that both methods provide information on baroreflex regulation. While the spontaneous method evaluates truly physiological (but small) pressure changes, the pharmacological method provides a more consistent and repetitive challenge for the reflex that requires a different recruitment of baroreflex effectors. Abstract The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late incubation using a novel method that measured changes in heart rate during spontaneous fluctuations in blood pressure. Our results suggest that a baroreflex is already functional at d17 with no indication of further maturation in terms of sensitivity (gain at 17 d was 52.9 ± 8.3 and at 20 d 69.5 ± 16.2 ms kPa−1 ). The physiological relevance of these values is shown using data surrogation methods. Although the results contrast with the progressive baroreflex maturation indicated by the pharmacological method, we sustain that both methods provide information on baroreflex regulation. While the spontaneous method evaluates truly physiological (but small) pressure changes, the pharmacological method provides a more consistent and repetitive challenge for the reflex that requires a different recruitment of baroreflex effectors. The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late incubation using a novel method that measured changes in heart rate during spontaneous fluctuations in blood pressure. Our results suggest that a baroreflex is already functional at d17 with no indication of further maturation in terms of sensitivity (gain at 17 d was 52.9 ± 8.3 and at 20 d 69.5 ± 16.2 ms kPa −1). The physiological relevance of these values is shown using data surrogation methods. Although the results contrast with the progressive baroreflex maturation indicated by the pharmacological method, we sustain that both methods provide information on baroreflex regulation. While the spontaneous method evaluates truly physiological (but small) pressure changes, the pharmacological method provides a more consistent and repetitive challenge for the reflex that requires a different recruitment of baroreflex effectors. The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late incubation using a novel method that measured changes in heart rate during spontaneous fluctuations in blood pressure. Our results suggest that a baroreflex is already functional at d17 with no indication of further maturation in terms of sensitivity (gain at 17 d was 52.9 ± 8.3 and at 20 d 69.5 ± 16.2 ms kPa −1 ). The physiological relevance of these values is shown using data surrogation methods. Although the results contrast with the progressive baroreflex maturation indicated by the pharmacological method, we sustain that both methods provide information on baroreflex regulation. While the spontaneous method evaluates truly physiological (but small) pressure changes, the pharmacological method provides a more consistent and repetitive challenge for the reflex that requires a different recruitment of baroreflex effectors. |
| Author | Elfwing, Magnus Altimiras, Jordi Lundengård, Karin |
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| CitedBy_id | crossref_primary_10_1016_j_cbpa_2022_111286 crossref_primary_10_1016_j_cbpa_2024_111654 crossref_primary_10_1590_s1806_92902016001100010 crossref_primary_10_1016_j_cbpa_2024_111576 crossref_primary_10_1016_j_resp_2012_02_002 crossref_primary_10_1152_ajpregu_00037_2022 crossref_primary_10_1152_ajpregu_00298_2013 crossref_primary_10_1016_j_resp_2011_04_010 crossref_primary_10_1016_j_resp_2013_05_030 |
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| Keywords | Spontaneous baroreflex Baroreflex sensitivity Sodium nitroprusside Cardiovascular development |
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| Snippet | Abstract The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and... The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance... |
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| SubjectTerms | Animals Baroreflex - physiology Baroreflex sensitivity Cardiovascular development Cardiovascular System - embryology Chick Embryo Medical Education Models, Biological NATURAL SCIENCES NATURVETENSKAP Pulmonary/Respiratory Sodium nitroprusside Spontaneous baroreflex |
| Title | Fetal development of baroreflex sensitivity: The chicken embryo as a case model |
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