Association of single-nucleotide polymorphisms in TLR7 (Gln11Leu) and TLR9 (1635A/G) with a higher CD4T cell count during HIV infection

• Published in: Immunology letters Vol. 160; no. 1; pp. 58 - 64
• Main Authors: Said, E.A, Al-Yafei, F, Zadjali, F, Hasson, S.S, Al-Balushi, M.S, Al-Mahruqi, S, Koh, C.Y, Al-Naamani, K, Al-Busaidi, J.Z, Idris, M.A, Balkhair, A, Al-Jabri, A.A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2014
• Subjects: Adult; Alleles; Allergy and Immunology; Amino Acid Substitution; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; CD4T cells; Female; Gene Frequency; Genotype; HIV; HIV Infections - drug therapy; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - virology; HIV-1 - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Single nucleotide polymorphism (SNP); Toll-like receptor; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 9 - genetics; Viral Load; Viremic; Viremic; HIV; Single nucleotide polymorphism (SNP); Toll-like receptor; CD4T cells
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2014.04.005

Highlights • A trend toward linking TLR7 Gln (AA) genotype to a normal CD4 count after viremia. • Patients with TLR9 1635 (AG) genotype had the highest CD4 count during viremia. • Patients with TLR9 1635 (GG) genotype had the lowest CD4 count during viremia. • Combining TLR7 Gln (AA)/ TLR9 1635 (AG) genotypes might be related to a higher CD4 count.