Oocyte-Secreted Serum Biomarkers GDF9 and BMP15 in Women with Endometriosis
Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent studies demonstrated that serum concentrations are associated with the number of oocytes retrieved during IVF, and therefore potential clinic...
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Published in | Reproductive sciences (Thousand Oaks, Calif.) Vol. 30; no. 5; pp. 1521 - 1527 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Springer International Publishing
01.05.2023
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Abstract | Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent studies demonstrated that serum concentrations are associated with the number of oocytes retrieved during IVF, and therefore potential clinical use as biomarkers. However, it is unknown if the presence of endometriosis affects serum GDF9 or BMP15. An exploratory case–control study was prospectively performed on 60 women who underwent laparoscopy between April 2017 and August 2018 at two hospitals. GDF9 and BMP15 were measured by validated immunoassays in pre-operative serum samples. Data were analysed relative to laparoscopic assessment of endometriosis and staging. There were 35 women with confirmed laparoscopic diagnosis of endometriosis and 25 controls with no evidence of endometriosis at laparoscopy. GDF9 was detectable in 40% of controls and 48% of cases. There was no difference in median GDF9 concentrations between controls (20.0 pg/ml, range 20.0–2504 pg/ml) and cases (20.0 pg/ml, range 20.0–2963 pg/ml). BMP15 was detectable in 48% of controls and 58% of cases, with no difference in median concentrations between controls (26.5 pg/ml, range 24.0–1499 pg/ml) and cases (24.0 pg/ml, range 24.0–796 pg/ml). Furthermore, there were no significant differences in the proportion of detectable samples or concentrations of GDF9 or BMP15 with differing severities of endometriosis. In conclusion, serum concentrations of oocyte-secreted factors, GDF9 and BMP15 did not differ between control patients and patients with endometriosis. For clinical application in reproductive medicine, GDF9 and BMP15 serum biomarker quantitation is unlikely to be aberrant in the presence of endometriosis. |
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AbstractList | Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent studies demonstrated that serum concentrations are associated with the number of oocytes retrieved during IVF, and therefore potential clinical use as biomarkers. However, it is unknown if the presence of endometriosis affects serum GDF9 or BMP15. An exploratory case-control study was prospectively performed on 60 women who underwent laparoscopy between April 2017 and August 2018 at two hospitals. GDF9 and BMP15 were measured by validated immunoassays in pre-operative serum samples. Data were analysed relative to laparoscopic assessment of endometriosis and staging. There were 35 women with confirmed laparoscopic diagnosis of endometriosis and 25 controls with no evidence of endometriosis at laparoscopy. GDF9 was detectable in 40% of controls and 48% of cases. There was no difference in median GDF9 concentrations between controls (20.0 pg/ml, range 20.0-2504 pg/ml) and cases (20.0 pg/ml, range 20.0-2963 pg/ml). BMP15 was detectable in 48% of controls and 58% of cases, with no difference in median concentrations between controls (26.5 pg/ml, range 24.0-1499 pg/ml) and cases (24.0 pg/ml, range 24.0-796 pg/ml). Furthermore, there were no significant differences in the proportion of detectable samples or concentrations of GDF9 or BMP15 with differing severities of endometriosis. In conclusion, serum concentrations of oocyte-secreted factors, GDF9 and BMP15 did not differ between control patients and patients with endometriosis. For clinical application in reproductive medicine, GDF9 and BMP15 serum biomarker quantitation is unlikely to be aberrant in the presence of endometriosis. Abstract Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent studies demonstrated that serum concentrations are associated with the number of oocytes retrieved during IVF, and therefore potential clinical use as biomarkers. However, it is unknown if the presence of endometriosis affects serum GDF9 or BMP15. An exploratory case–control study was prospectively performed on 60 women who underwent laparoscopy between April 2017 and August 2018 at two hospitals. GDF9 and BMP15 were measured by validated immunoassays in pre-operative serum samples. Data were analysed relative to laparoscopic assessment of endometriosis and staging. There were 35 women with confirmed laparoscopic diagnosis of endometriosis and 25 controls with no evidence of endometriosis at laparoscopy. GDF9 was detectable in 40% of controls and 48% of cases. There was no difference in median GDF9 concentrations between controls (20.0 pg/ml, range 20.0–2504 pg/ml) and cases (20.0 pg/ml, range 20.0–2963 pg/ml). BMP15 was detectable in 48% of controls and 58% of cases, with no difference in median concentrations between controls (26.5 pg/ml, range 24.0–1499 pg/ml) and cases (24.0 pg/ml, range 24.0–796 pg/ml). Furthermore, there were no significant differences in the proportion of detectable samples or concentrations of GDF9 or BMP15 with differing severities of endometriosis. In conclusion, serum concentrations of oocyte-secreted factors, GDF9 and BMP15 did not differ between control patients and patients with endometriosis. For clinical application in reproductive medicine, GDF9 and BMP15 serum biomarker quantitation is unlikely to be aberrant in the presence of endometriosis. |
Author | Riepsamen, Angelique H. Gilchrist, Robert B. Ledger, William L. Rodgers, Rachael J. Shamsa, Aiat Robertson, David M. Donoghoe, Mark W. Abbott, Jason A. |
Author_xml | – sequence: 1 givenname: Aiat orcidid: 0000-0001-7649-1051 surname: Shamsa fullname: Shamsa, Aiat email: aiat.shamsa@gmail.com organization: Clinical School of Medicine, University of New South Wales, Royal Hospital for Women – sequence: 2 givenname: Robert B. surname: Gilchrist fullname: Gilchrist, Robert B. organization: Clinical School of Medicine, University of New South Wales – sequence: 3 givenname: David M. surname: Robertson fullname: Robertson, David M. organization: Clinical School of Medicine, University of New South Wales – sequence: 4 givenname: Rachael J. surname: Rodgers fullname: Rodgers, Rachael J. organization: Royal Hospital for Women – sequence: 5 givenname: Mark W. surname: Donoghoe fullname: Donoghoe, Mark W. organization: Stats Central, Mark Wainwright Analytical Centre, University of New South Wales – sequence: 6 givenname: William L. surname: Ledger fullname: Ledger, William L. organization: Clinical School of Medicine, University of New South Wales, Royal Hospital for Women – sequence: 7 givenname: Jason A. surname: Abbott fullname: Abbott, Jason A. organization: Clinical School of Medicine, University of New South Wales, Royal Hospital for Women – sequence: 8 givenname: Angelique H. surname: Riepsamen fullname: Riepsamen, Angelique H. organization: Clinical School of Medicine, University of New South Wales |
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Cites_doi | 10.1016/j.fertnstert.2021.02.001 10.1074/jbc.M115.671487 10.1016/j.jbi.2008.08.010 10.1111/1471-0528.16447 10.1016/j.fertnstert.2017.01.009 10.1016/j.fertnstert.2009.10.011 10.1093/humrep/det457 10.1111/aogs.13931 10.1016/j.jmig.2019.10.020 10.1093/humupd/dmt053 10.1210/jc.2013-3949 10.1155/2014/179515 10.1038/s41598-020-73389-2 10.1210/en.2019-00264 10.1016/j.fertnstert.2018.06.025 10.1093/humupd/dmu036 10.1007/s12522-015-0208-6 10.1007/s10815-019-01450-9 10.1016/j.fertnstert.2018.03.015 10.1056/NEJMra0804690 10.1016/j.rbmo.2020.09.014 10.1002/humu.20961 10.1371/journal.pone.0223316 10.1093/humupd/dmm040 10.1093/edrv/38.supp.1 10.1186/s13048-017-0341-4 10.1080/00031305.1992.10475837 |
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Keywords | GDF9 Oocyte-secreted factors Endometriosis Biomarker BMP15 |
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References | Sanchez, Vigano, Somigliana, Panina-Bordignon, Vercellini, Candiani (CR11) 2014; 20 Muzii, Di Tucci, Di Feliciantonio, Galati, Di Donato, Musella (CR34) 2018; 110 Riepsamen, Chan, Lien, Sweeten, Donoghoe, Walker (CR15) 2019; 160 Kawabe, Yamashita, Saito, Kokunai, Hayashi, Hayashi (CR20) 2015; 14 Hendarto, Prabowo, Moeloek, Soetjipto (CR19) 2010; 94 Riepsamen, Donoghoe, Baerwald, Pankhurst, Lien, Harng Chong (CR21) 2021; 116 Tian, Zhang, Zhang, Wang, Zhu (CR12) 2020; 42 Simpson, Robertson, Al-Musawi, Heath, McNatty, Ritter (CR14) 2014; 99 Romanski, Brady, Farland, Thomas, Hornstein (CR28) 2019; 36 De Conto, Matte, Cunha-Filho (CR29) 2020; 100 Gupta, Hull, Fraser, Miller, Bossuyt, Johnson (CR8) 2016; 4 Kasapoglu, Ata, Uyaniklar, Seyhan, Orhan, Yildiz Oguz (CR33) 2018; 110 Armour, Lawson, Wood, Smith, Abbott (CR6) 2019; 14 Armour, Sinclair, Ng, Hyman, Lawson, Smith (CR1) 2020; 10 Nisenblat, Bossuyt, Shaikh, Farquhar, Jordan, Scheffers (CR9) 2016; 5 Rossetti, Di Pasquale, Marozzi, Bione, Toniolo, Grammatico (CR16) 2009; 30 Persani, Rossetti, Di Pasquale, Cacciatore, Fabre (CR18) 2014; 20 Dunselman, Vermeulen, Becker, Calhaz-Jorge, D'Hooghe, De Bie (CR7) 2014; 29 Patiño, Walton, Mueller, Johnson, Stocker, Richani (CR17) 2017; 102 Sourial, Tempest, Hapangama (CR5) 2014; 2014 CR27 CR26 Waller, Turnbull (CR25) 1992; 46 Mottershead, Sugimura, Al-Musawi, Li, Richani, White (CR32) 2015; 290 Bulun (CR4) 2009; 360 CR24 Muna, Wiweko, Rectifa, Mutia, Riayati, Iffanolida (CR31) 2018; 1073 CR22 Wiweko, Iffanolida, Rectifa, Muna, Mutia, Febri (CR30) 2018; 1073 Ahn, Singh, Tayade (CR10) 2017; 107 Rowlands, Abbott, Montgomery, Hockey, Rogers, Mishra (CR2) 2020; 128 Montgomery, Mortlock, Giudice (CR3) 2019; 27 Gilchrist, Lane, Thompson (CR13) 2008; 14 Harris, Taylor, Thielke, Payne, Gonzalez, Conde (CR23) 2009; 42 Z Tian (1107_CR12) 2020; 42 D Gupta (1107_CR8) 2016; 4 LC Patiño (1107_CR17) 2017; 102 L Persani (1107_CR18) 2014; 20 IJ Rowlands (1107_CR2) 2020; 128 S Kawabe (1107_CR20) 2015; 14 AH Riepsamen (1107_CR21) 2021; 116 GW Montgomery (1107_CR3) 2019; 27 E De Conto (1107_CR29) 2020; 100 B Wiweko (1107_CR30) 2018; 1073 GA Dunselman (1107_CR7) 2014; 29 SH Ahn (1107_CR10) 2017; 107 N Muna (1107_CR31) 2018; 1073 M Armour (1107_CR6) 2019; 14 AM Sanchez (1107_CR11) 2014; 20 1107_CR22 I Kasapoglu (1107_CR33) 2018; 110 RB Gilchrist (1107_CR13) 2008; 14 1107_CR26 PA Harris (1107_CR23) 2009; 42 1107_CR24 LA Waller (1107_CR25) 1992; 46 1107_CR27 SE Bulun (1107_CR4) 2009; 360 AH Riepsamen (1107_CR15) 2019; 160 M Armour (1107_CR1) 2020; 10 S Sourial (1107_CR5) 2014; 2014 V Nisenblat (1107_CR9) 2016; 5 PA Romanski (1107_CR28) 2019; 36 DG Mottershead (1107_CR32) 2015; 290 L Muzii (1107_CR34) 2018; 110 CM Simpson (1107_CR14) 2014; 99 H Hendarto (1107_CR19) 2010; 94 R Rossetti (1107_CR16) 2009; 30 |
References_xml | – ident: CR22 – volume: 116 start-page: 546 issue: 2 year: 2021 end-page: 557 ident: CR21 article-title: Exploratory analysis of serum concentrations of oocyte biomarkers growth differentiation factor 9 and bone morphogenetic protein 15 in ovulatory women across the menstrual cycle publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2021.02.001 contributor: fullname: Harng Chong – volume: 102 start-page: 1009 issue: 3 year: 2017 end-page: 1019 ident: CR17 article-title: BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9 publication-title: J Clin Endocrinol Metab contributor: fullname: Richani – volume: 290 start-page: 24007 issue: 39 year: 2015 end-page: 24020 ident: CR32 article-title: Cumulin, an Oocyte-secreted heterodimer of the transforming growth factor-beta family, is a potent activator of granulosa cells and improves oocyte quality publication-title: J Biol Chem doi: 10.1074/jbc.M115.671487 contributor: fullname: White – volume: 42 start-page: 377 issue: 2 year: 2009 end-page: 381 ident: CR23 article-title: Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support publication-title: J Biomed Inform doi: 10.1016/j.jbi.2008.08.010 contributor: fullname: Conde – volume: 128 start-page: 657 issue: 4 year: 2020 end-page: 665 ident: CR2 article-title: Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study publication-title: BJOG doi: 10.1111/1471-0528.16447 contributor: fullname: Mishra – volume: 107 start-page: 523 issue: 3 year: 2017 end-page: 532 ident: CR10 article-title: Biomarkers in endometriosis: challenges and opportunities publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2017.01.009 contributor: fullname: Tayade – volume: 94 start-page: 758 issue: 2 year: 2010 end-page: 760 ident: CR19 article-title: Growth differentiation factor 9 concentration in the follicular fluid of infertile women with endometriosis publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2009.10.011 contributor: fullname: Soetjipto – volume: 29 start-page: 400 issue: 3 year: 2014 end-page: 412 ident: CR7 article-title: ESHRE guideline: management of women with endometriosis publication-title: Hum Reprod doi: 10.1093/humrep/det457 contributor: fullname: De Bie – volume: 100 start-page: 868 issue: 5 year: 2020 end-page: 875 ident: CR29 article-title: BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility publication-title: Acta Obstet Gynecol Scand doi: 10.1111/aogs.13931 contributor: fullname: Cunha-Filho – volume: 27 start-page: 280 issue: 2 year: 2019 end-page: 286 ident: CR3 article-title: Should genetics now be considered the pre-eminent etiological factor in endometriosis? publication-title: J Minim Invasive Gynecol doi: 10.1016/j.jmig.2019.10.020 contributor: fullname: Giudice – volume: 20 start-page: 217 issue: 2 year: 2014 end-page: 230 ident: CR11 article-title: The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary publication-title: Hum Reprod Update doi: 10.1093/humupd/dmt053 contributor: fullname: Candiani – volume: 4 start-page: CD012165 year: 2016 ident: CR8 article-title: Endometrial biomarkers for the non-invasive diagnosis of endometriosis publication-title: Cochrane Database Syst Rev contributor: fullname: Johnson – volume: 99 start-page: E615 issue: 4 year: 2014 end-page: E624 ident: CR14 article-title: Aberrant GDF9 expression and activation are associated with common human ovarian disorders publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-3949 contributor: fullname: Ritter – ident: CR27 – volume: 2014 start-page: 179515 year: 2014 ident: CR5 article-title: Theories on the pathogenesis of endometriosis publication-title: Int J Reprod Med doi: 10.1155/2014/179515 contributor: fullname: Hapangama – volume: 1073 start-page: 032049 year: 2018 ident: CR31 article-title: Study of GDF9 and BMP15 mRNA profiles in granulosa cells to predict oocyte quality in endometriosis patients undergoing in vitro fertilization publication-title: J Phys: Conf Ser contributor: fullname: Iffanolida – volume: 10 start-page: 16253 issue: 1 year: 2020 ident: CR1 article-title: Endometriosis and chronic pelvic pain have similar impact on women, but time to diagnosis is decreasing: an Australian survey publication-title: Sci Rep doi: 10.1038/s41598-020-73389-2 contributor: fullname: Smith – volume: 160 start-page: 2298 issue: 10 year: 2019 end-page: 2313 ident: CR15 article-title: Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies publication-title: Endocrinology doi: 10.1210/en.2019-00264 contributor: fullname: Walker – volume: 5 start-page: CD012179 year: 2016 ident: CR9 article-title: 2016 Blood biomarkers for the non-invasive diagnosis of endometriosis publication-title: Cochrane Database Syst Rev contributor: fullname: Scheffers – volume: 110 start-page: 932 issue: 5 year: 2018 end-page: 40.e1 ident: CR34 article-title: Antimüllerian hormone is reduced in the presence of ovarian endometriomas: a systematic review and meta-analysis publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.06.025 contributor: fullname: Musella – volume: 20 start-page: 869 issue: 6 year: 2014 end-page: 883 ident: CR18 article-title: The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders publication-title: Hum Reprod Update doi: 10.1093/humupd/dmu036 contributor: fullname: Fabre – volume: 14 start-page: 179 issue: 4 year: 2015 end-page: 184 ident: CR20 article-title: The effect of moderate to severe endometriosis on expression of growth differentiation factor-9 mRNA in human granulosa cells under controlled ovarian hyperstimulation publication-title: Reprod Med Biol doi: 10.1007/s12522-015-0208-6 contributor: fullname: Hayashi – volume: 46 start-page: 5 issue: 1 year: 1992 end-page: 12 ident: CR25 article-title: Probability plotting with censored data publication-title: Am Stat contributor: fullname: Turnbull – volume: 36 start-page: 1179 issue: 6 year: 2019 end-page: 1184 ident: CR28 article-title: The effect of endometriosis on the antimüllerian hormone level in the infertile population publication-title: J Assist Reprod Genet doi: 10.1007/s10815-019-01450-9 contributor: fullname: Hornstein – volume: 110 start-page: 122 issue: 1 year: 2018 end-page: 127 ident: CR33 article-title: Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.03.015 contributor: fullname: Yildiz Oguz – volume: 360 start-page: 268 issue: 3 year: 2009 end-page: 279 ident: CR4 article-title: Endometriosis publication-title: N Engl J Med doi: 10.1056/NEJMra0804690 contributor: fullname: Bulun – volume: 42 start-page: 237 issue: 1 year: 2020 end-page: 247 ident: CR12 article-title: Antral follicle count is reduced in the presence of endometriosis: a systematic review and meta-analysis publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2020.09.014 contributor: fullname: Zhu – volume: 30 start-page: 804 issue: 5 year: 2009 end-page: 810 ident: CR16 article-title: BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein publication-title: Hum Mutat doi: 10.1002/humu.20961 contributor: fullname: Grammatico – volume: 14 start-page: e0223316 issue: 10 year: 2019 ident: CR6 article-title: The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: a national online survey publication-title: PLoS ONE doi: 10.1371/journal.pone.0223316 contributor: fullname: Abbott – volume: 14 start-page: 159 issue: 2 year: 2008 end-page: 177 ident: CR13 article-title: Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality publication-title: Hum Reprod Update doi: 10.1093/humupd/dmm040 contributor: fullname: Thompson – volume: 1073 start-page: 1 issue: 3 year: 2018 end-page: 5 ident: CR30 article-title: BMP15 mRNA profile in granulosa cells from endometriosis patients undergoing in vitro fertilization publication-title: J Phys: Conf Ser contributor: fullname: Febri – ident: CR26 – ident: CR24 – volume: 29 start-page: 400 issue: 3 year: 2014 ident: 1107_CR7 publication-title: Hum Reprod doi: 10.1093/humrep/det457 contributor: fullname: GA Dunselman – volume: 42 start-page: 237 issue: 1 year: 2020 ident: 1107_CR12 publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2020.09.014 contributor: fullname: Z Tian – ident: 1107_CR22 doi: 10.1093/edrv/38.supp.1 – volume: 160 start-page: 2298 issue: 10 year: 2019 ident: 1107_CR15 publication-title: Endocrinology doi: 10.1210/en.2019-00264 contributor: fullname: AH Riepsamen – ident: 1107_CR27 doi: 10.1186/s13048-017-0341-4 – volume: 14 start-page: 159 issue: 2 year: 2008 ident: 1107_CR13 publication-title: Hum Reprod Update doi: 10.1093/humupd/dmm040 contributor: fullname: RB Gilchrist – volume: 99 start-page: E615 issue: 4 year: 2014 ident: 1107_CR14 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-3949 contributor: fullname: CM Simpson – volume: 36 start-page: 1179 issue: 6 year: 2019 ident: 1107_CR28 publication-title: J Assist Reprod Genet doi: 10.1007/s10815-019-01450-9 contributor: fullname: PA Romanski – volume: 46 start-page: 5 issue: 1 year: 1992 ident: 1107_CR25 publication-title: Am Stat doi: 10.1080/00031305.1992.10475837 contributor: fullname: LA Waller – volume: 107 start-page: 523 issue: 3 year: 2017 ident: 1107_CR10 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2017.01.009 contributor: fullname: SH Ahn – volume: 94 start-page: 758 issue: 2 year: 2010 ident: 1107_CR19 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2009.10.011 contributor: fullname: H Hendarto – volume: 1073 start-page: 032049 year: 2018 ident: 1107_CR31 publication-title: J Phys: Conf Ser contributor: fullname: N Muna – ident: 1107_CR24 – volume: 2014 start-page: 179515 year: 2014 ident: 1107_CR5 publication-title: Int J Reprod Med doi: 10.1155/2014/179515 contributor: fullname: S Sourial – volume: 5 start-page: CD012179 year: 2016 ident: 1107_CR9 publication-title: Cochrane Database Syst Rev contributor: fullname: V Nisenblat – volume: 30 start-page: 804 issue: 5 year: 2009 ident: 1107_CR16 publication-title: Hum Mutat doi: 10.1002/humu.20961 contributor: fullname: R Rossetti – ident: 1107_CR26 – volume: 116 start-page: 546 issue: 2 year: 2021 ident: 1107_CR21 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2021.02.001 contributor: fullname: AH Riepsamen – volume: 290 start-page: 24007 issue: 39 year: 2015 ident: 1107_CR32 publication-title: J Biol Chem doi: 10.1074/jbc.M115.671487 contributor: fullname: DG Mottershead – volume: 128 start-page: 657 issue: 4 year: 2020 ident: 1107_CR2 publication-title: BJOG doi: 10.1111/1471-0528.16447 contributor: fullname: IJ Rowlands – volume: 100 start-page: 868 issue: 5 year: 2020 ident: 1107_CR29 publication-title: Acta Obstet Gynecol Scand doi: 10.1111/aogs.13931 contributor: fullname: E De Conto – volume: 20 start-page: 869 issue: 6 year: 2014 ident: 1107_CR18 publication-title: Hum Reprod Update doi: 10.1093/humupd/dmu036 contributor: fullname: L Persani – volume: 110 start-page: 932 issue: 5 year: 2018 ident: 1107_CR34 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.06.025 contributor: fullname: L Muzii – volume: 42 start-page: 377 issue: 2 year: 2009 ident: 1107_CR23 publication-title: J Biomed Inform doi: 10.1016/j.jbi.2008.08.010 contributor: fullname: PA Harris – volume: 4 start-page: CD012165 year: 2016 ident: 1107_CR8 publication-title: Cochrane Database Syst Rev contributor: fullname: D Gupta – volume: 14 start-page: 179 issue: 4 year: 2015 ident: 1107_CR20 publication-title: Reprod Med Biol doi: 10.1007/s12522-015-0208-6 contributor: fullname: S Kawabe – volume: 1073 start-page: 1 issue: 3 year: 2018 ident: 1107_CR30 publication-title: J Phys: Conf Ser contributor: fullname: B Wiweko – volume: 110 start-page: 122 issue: 1 year: 2018 ident: 1107_CR33 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.03.015 contributor: fullname: I Kasapoglu – volume: 20 start-page: 217 issue: 2 year: 2014 ident: 1107_CR11 publication-title: Hum Reprod Update doi: 10.1093/humupd/dmt053 contributor: fullname: AM Sanchez – volume: 102 start-page: 1009 issue: 3 year: 2017 ident: 1107_CR17 publication-title: J Clin Endocrinol Metab contributor: fullname: LC Patiño – volume: 360 start-page: 268 issue: 3 year: 2009 ident: 1107_CR4 publication-title: N Engl J Med doi: 10.1056/NEJMra0804690 contributor: fullname: SE Bulun – volume: 10 start-page: 16253 issue: 1 year: 2020 ident: 1107_CR1 publication-title: Sci Rep doi: 10.1038/s41598-020-73389-2 contributor: fullname: M Armour – volume: 27 start-page: 280 issue: 2 year: 2019 ident: 1107_CR3 publication-title: J Minim Invasive Gynecol doi: 10.1016/j.jmig.2019.10.020 contributor: fullname: GW Montgomery – volume: 14 start-page: e0223316 issue: 10 year: 2019 ident: 1107_CR6 publication-title: PLoS ONE doi: 10.1371/journal.pone.0223316 contributor: fullname: M Armour |
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Snippet | Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent... Abstract Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female... |
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SubjectTerms | Biomarkers - metabolism Bone Morphogenetic Protein 15 - metabolism Case-Control Studies Embryology Endometriosis - diagnosis Endometriosis - metabolism Female Growth Differentiation Factor 9 - metabolism Humans Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Oocytes - metabolism Reproductive Biology: Original Reproductive Biology: Original Article Reproductive Medicine |
Title | Oocyte-Secreted Serum Biomarkers GDF9 and BMP15 in Women with Endometriosis |
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