The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse

The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for the laboratory mouse, a premier animal model for the study of genetic and genomic systems relevant to human biology and disease. MGD maintains a comprehensive catalog of genes, func...

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Published inNucleic acids research Vol. 42; no. Database issue; pp. D810 - D817
Main Authors Blake, Judith A, Bult, Carol J, Eppig, Janan T, Kadin, James A, Richardson, Joel E
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2014
Subjects
Animals
Databases, Genetic
Genome
Genomics
Humans
Internet
Mice - genetics
Molecular Sequence Annotation
Phenotype
Quantitative Trait Loci
Rats
V. Human genome, model organisms, comparative genomics
Online AccessGet full text

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Abstract The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for the laboratory mouse, a premier animal model for the study of genetic and genomic systems relevant to human biology and disease. MGD maintains a comprehensive catalog of genes, functional RNAs and other genome features as well as heritable phenotypes and quantitative trait loci. The genome feature catalog is generated by the integration of computational and manual genome annotations generated by NCBI, Ensembl and Vega/HAVANA. MGD curates and maintains the comprehensive listing of functional annotations for mouse genes using the Gene Ontology, and MGD curates and integrates comprehensive phenotype annotations including associations of mouse models with human diseases. Recent improvements include integration of the latest mouse genome build (GRCm38), improved access to comparative and functional annotations for mouse genes with expanded representation of comparative vertebrate genomes and new loads of phenotype data from high-throughput phenotyping projects. All MGD resources are freely available to the research community.
AbstractList The Mouse Genome Database (MGD) ( http://www.informatics.jax.org ) is the community model organism database resource for the laboratory mouse, a premier animal model for the study of genetic and genomic systems relevant to human biology and disease. MGD maintains a comprehensive catalog of genes, functional RNAs and other genome features as well as heritable phenotypes and quantitative trait loci. The genome feature catalog is generated by the integration of computational and manual genome annotations generated by NCBI, Ensembl and Vega/HAVANA. MGD curates and maintains the comprehensive listing of functional annotations for mouse genes using the Gene Ontology, and MGD curates and integrates comprehensive phenotype annotations including associations of mouse models with human diseases. Recent improvements include integration of the latest mouse genome build (GRCm38), improved access to comparative and functional annotations for mouse genes with expanded representation of comparative vertebrate genomes and new loads of phenotype data from high-throughput phenotyping projects. All MGD resources are freely available to the research community.
The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for the laboratory mouse, a premier animal model for the study of genetic and genomic systems relevant to human biology and disease. MGD maintains a comprehensive catalog of genes, functional RNAs and other genome features as well as heritable phenotypes and quantitative trait loci. The genome feature catalog is generated by the integration of computational and manual genome annotations generated by NCBI, Ensembl and Vega/HAVANA. MGD curates and maintains the comprehensive listing of functional annotations for mouse genes using the Gene Ontology, and MGD curates and integrates comprehensive phenotype annotations including associations of mouse models with human diseases. Recent improvements include integration of the latest mouse genome build (GRCm38), improved access to comparative and functional annotations for mouse genes with expanded representation of comparative vertebrate genomes and new loads of phenotype data from high-throughput phenotyping projects. All MGD resources are freely available to the research community.
Author Blake, Judith A
Bult, Carol J
Richardson, Joel E
Eppig, Janan T
Kadin, James A
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  surname: Richardson
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Tomczuk, M
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Washburn, L L
Giannatto, S L
McAndrews, M
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Bello, S M
Sitnikov, D
Motenko, H
Zhu, Y
Ni, L
L, K
Richards-Smith, B
Dolan, M E
Corbani, L E
Smith, C L
Hale, P
Drabkin, H J
Onda, H
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The members of the Mouse Genome Database Group are provided in the Acknowledgements.
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Snippet The Mouse Genome Database (MGD) (http://www.informatics.jax.org) is the community model organism database resource for the laboratory mouse, a premier animal...
The Mouse Genome Database (MGD) ( http://www.informatics.jax.org ) is the community model organism database resource for the laboratory mouse, a premier animal...
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SubjectTerms Animals
Databases, Genetic
Genome
Genomics
Humans
Internet
Mice - genetics
Molecular Sequence Annotation
Phenotype
Quantitative Trait Loci
Rats
V. Human genome, model organisms, comparative genomics
Title The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse
URI https://www.ncbi.nlm.nih.gov/pubmed/24285300
https://search.proquest.com/docview/1490741106
https://pubmed.ncbi.nlm.nih.gov/PMC3964950
Volume 42
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