Human Immunodeficiency Virus Type 1 Alters Brain-Derived Neurotrophic Factor Processing in Neurons

• Published in: The Journal of neuroscience Vol. 32; no. 28; pp. 9477 - 9484
• Main Authors: Bachis, A., Avdoshina, V., Zecca, L., Parsadanian, M., Mocchetti, I.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 11.07.2012
• Subjects: Adolescent; Adult; Analysis of Variance; Animals; Animals, Newborn; Brain - metabolism; Brain - pathology; Brain - virology; Brain-Derived Neurotrophic Factor - metabolism; Carbazoles - pharmacology; Cells, Cultured; Cerebellum - cytology; Enzyme Inhibitors - pharmacology; Enzyme-Linked Immunosorbent Assay - methods; Female; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; HIV Envelope Protein gp120 - pharmacology; HIV Infections - metabolism; HIV Infections - pathology; HIV-1 - genetics; HIV-1 - metabolism; Human immunodeficiency virus 1; Humans; Indole Alkaloids - pharmacology; Male; Middle Aged; Neurites - drug effects; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Neurons - virology; Peptides - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Nerve Growth Factor - genetics; Receptors, Nerve Growth Factor - metabolism; Time Factors

The molecular mechanisms leading to synaptic simplification and neuronal apoptosis in human immunodeficiency virus type 1 (HIV-1)-positive subjects are unknown. The HIV protein gp120 reduced the length of neuronal processes similarly to the proneurotrophin pro-brain-derived neurotrophic factor (proB...