Anemia in the pediatric patient

The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinop...

Full description

Saved in:
Bibliographic Details
Published inBlood Vol. 140; no. 6; pp. 571 - 593
Main Author Gallagher, Patrick G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 11.08.2022
American Society of Hematology
Subjects
Anemia - diagnosis
Anemia - etiology
Anemia - therapy
Anemia, Iron-Deficiency - drug therapy
Child
Child, Preschool
Genetic Testing
Humans
Nervous System Diseases
Pediatric Hematology
Online AccessGet full text

Cover

Abstract The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases. •Anemia is a major global burden, affecting almost 2 billion people worldwide, particularly infants and young children.•Population approaches are being employed to treat dietary anemia, and therapeutic advances are improving care for inherited anemias. [Display omitted]
AbstractList The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases. •Anemia is a major global burden, affecting almost 2 billion people worldwide, particularly infants and young children.•Population approaches are being employed to treat dietary anemia, and therapeutic advances are improving care for inherited anemias. [Display omitted]
Commissioned and introduced by Associate Editors Irene Roberts and Thomas Ortel, this Review Series focuses on common areas in pediatric hematology practice, emphasizing new therapeutic and diagnostic developments. The specific challenges of managing hemostatic and thrombotic disorders in children are described by O’Brien and Zia. Distinguishing acquired immune diseases from inherited disorders of blood counts is a common problem for pediatric hematologists, and this is tackled in reviews by Grace and Lambert for thrombocytopenias and by Dokal et al for bone marrow failure. Finally, Gallagher provides a stepwise approach to the diagnosis and treatment of anemia in infancy and childhood, at both the individual patient level and the population level. Anemia is a major global burden, affecting almost 2 billion people worldwide, particularly infants and young children. Population approaches are being employed to treat dietary anemia, and therapeutic advances are improving care for inherited anemias. The World Health Organization estimates that approximately a quarter of the world’s population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases.
The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases.
The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases.The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age children. Globally, iron deficiency anemia is the most common cause of anemia. Other important causes of anemia in children are hemoglobinopathies, infection, and other chronic diseases. Anemia is associated with increased morbidity, including neurologic complications, increased risk of low birth weight, infection, and heart failure, as well as increased mortality. When approaching a child with anemia, detailed historical information, particularly diet, environmental exposures, and family history, often yield important clues to the diagnosis. Dysmorphic features on physical examination may indicate syndromic causes of anemia. Diagnostic testing involves a stepwise approach utilizing various laboratory techniques. The increasing availability of genetic testing is providing new mechanistic insights into inherited anemias and allowing diagnosis in many previously undiagnosed cases. Population-based approaches are being taken to address nutritional anemias. Novel pharmacologic agents and advances in gene therapy-based therapeutics have the potential to ameliorate anemia-associated disease and provide treatment strategies even in the most difficult and complex cases.
Author Gallagher, Patrick G.
AuthorAffiliation Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT
AuthorAffiliation_xml – name: Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT
Author_xml – sequence: 1
  givenname: Patrick G.
  surname: Gallagher
  fullname: Gallagher, Patrick G.
  email: patrick.gallagher@yale.edu
  organization: Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35213686$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtLAzEQx4NUtD7unrRHL6uTZJPNehBK8QUFL3oO2eysRrabmmwFv72prU_Q08DM_wG_2SGDzndIyAGFE0oVO61a7-sTBgwAZF6UG2RIBVMZpM2ADJfbLC8Luk12YnwCoDlnYotsc8Eol0oOydG4w5kzI9eN-kcczbF2pg_Ojuamd9j1e2SzMW3E_fXcJfeXF3eT62x6e3UzGU8zm-dFnxmBFhvGqqZqOKOFFKYCMEwBz0UjcgXKlkwCaygruKCNrEtUda6E5ZXhlu-S81XufFHNsLapOphWz4ObmfCqvXH656Vzj_rBv-iSFxyoSgHH64DgnxcYez1z0WLbmg79ImomOVdCglhKD793fZZ8UEkCuRLY4GMM2Gjr-sTDL6tdqynoJX79jl9_4U9G-GX8yP7HcrayYKL74jDoaBN4mx4R0Pa69u5v8xvWR5q1
CitedBy_id crossref_primary_10_3389_fpubh_2024_1333069
crossref_primary_10_1002_iub_2897
crossref_primary_10_1007_s00431_024_05798_8
crossref_primary_10_3389_fped_2024_1487121
crossref_primary_10_1016_j_cps_2024_08_010
crossref_primary_10_15264_cpho_2023_30_2_85
crossref_primary_10_2147_PHMT_S389105
crossref_primary_10_11648_j_ajp_20251101_12
crossref_primary_10_12677_acm_2024_1472067
crossref_primary_10_3389_fped_2022_1008507
crossref_primary_10_1016_j_tem_2023_12_006
crossref_primary_10_3389_fonc_2024_1457886
crossref_primary_10_1080_17474086_2024_2329596
crossref_primary_10_22159_ajpcr_2024v17i8_52196
crossref_primary_10_4274_balkanmedj_galenos_2023_2023_9_86
crossref_primary_10_3390_nu16070936
crossref_primary_10_1017_S1047951123003463
crossref_primary_10_3390_healthcare13060635
crossref_primary_10_3390_jcm13154403
crossref_primary_10_1155_2024_1687917
crossref_primary_10_1186_s13052_025_01944_6
crossref_primary_10_1111_bjh_19930
crossref_primary_10_4103_jfmpc_jfmpc_1734_23
crossref_primary_10_53986_ibjm_2024_0024
crossref_primary_10_1016_j_htct_2025_103737
crossref_primary_10_22141_2224_0551_18_6_2023_1629
crossref_primary_10_1038_s41467_024_50066_w
crossref_primary_10_1093_jpids_piae091
crossref_primary_10_7189_jogh_14_04073
crossref_primary_10_1097_MPH_0000000000002829
crossref_primary_10_1002_jpn3_12454
crossref_primary_10_1007_s00112_024_02073_w
crossref_primary_10_1177_1721727X241291339
crossref_primary_10_1177_20552076241297057
crossref_primary_10_22159_ajpcr_2024_v17i5_51128
crossref_primary_10_1016_j_jpeds_2025_114557
crossref_primary_10_4103_joah_joah_27_23
crossref_primary_10_3389_fnut_2024_1474664
crossref_primary_10_4103_ijnpnd_ijnpnd_1_24
Cites_doi 10.1038/nrdp.2017.28
10.1111/bjh.15817
10.1016/j.ajhg.2009.02.006
10.1016/S0889-8588(18)30422-2
10.1111/bjh.14444
10.1182/blood-2016-11-693689
10.2165/00148581-200709010-00002
10.1038/nrc.2017.116
10.1007/s00277-018-3407-5
10.1182/blood-2018-08-815951
10.1016/j.ajhg.2018.10.027
10.1016/j.bbmt.2017.12.782
10.3949/ccjm.87a.19072
10.1111/trf.14196
10.1111/bjh.15701
10.1016/S2352-3026(19)30206-6
10.1016/j.arcped.2019.06.003
10.1111/bjh.14654
10.3324/haematol.2018.206540
10.1136/archdischild-2018-315705
10.1182/blood.2019000944
10.1056/NEJMra1804281
10.2174/1389201019666180712115215
10.1186/s13023-020-01429-1
10.1038/nrdp.2017.20
10.1111/ijlh.12657
10.1016/j.tmrv.2016.05.008
10.1542/peds.2010-2576
10.1097/MPH.0000000000000542
10.1182/blood-2013-07-460337
10.1038/nrdp.2017.40
10.1016/j.ajhg.2020.10.013
10.1586/17474086.2016.1131608
10.1182/blood-2018-06-856500
10.1089/ham.2018.0032
10.1111/ped.13776
10.1111/ejh.13107
10.1097/GIM.0b013e3181cd68ed
10.1101/cshperspect.a011734
10.1016/S0140-6736(20)32594-0
10.1016/j.hoc.2015.11.004
10.1056/NEJMra1404415
10.1182/asheducation-2015.1.392
10.1097/MPH.0000000000001382
10.1182/asheducation-2009.1.26
10.1111/nyas.14092
10.1182/blood-2017-10-810796
10.2147/JBM.S232644
10.1111/bjh.16100
10.1515/cclm-2018-1236
10.1128/microbiolspec.DMIH2-0008-2015
10.1097/MOP.0b013e32835d7f2c
10.1016/j.hoc.2019.01.011
10.1007/s40291-018-0368-2
10.1093/pch/12.4.333
10.1002/ajmg.a.61433
10.1016/j.siny.2008.02.006
10.1182/blood-2021-150097
10.1097/PEC.0000000000001760
10.1016/S0022-3476(78)80429-6
10.1056/NEJMra1401038
10.1016/j.prp.2019.152578
10.1111/j.1538-7836.2010.03940.x
10.3390/nu12072001
10.1002/pbc.27000
10.1097/MPH.0000000000000127
10.1056/NEJM198202043060507
10.1016/j.transci.2018.07.014
10.1016/j.hoc.2019.01.003
10.1182/blood-2012-10-461392
10.1182/blood-2017-09-765214
10.3389/fphys.2019.01294
10.1007/BF00441882
10.3389/fphys.2021.684569
10.1093/oxfordjournals.ndt.a027970
10.1016/j.bone.2018.03.002
10.1056/NEJMra1510865
10.1159/000508920
10.1007/s12185-018-2411-9
10.1111/j.1365-2141.2011.08724.x
10.1002/pbc.28949
10.1182/blood-2016-08-697110
10.1016/j.mayocp.2019.04.032
10.1016/j.hoc.2019.01.014
10.1111/trf.13147
10.1159/000488753
10.1016/j.hoc.2018.03.001
10.1016/j.ccc.2019.11.004
10.3324/haematol.2010.036053
10.1016/j.siny.2015.12.003
10.1001/jama.2017.6846
10.1038/s41467-017-01590-5
10.1007/s11912-018-0716-8
10.1002/pbc.28841
10.2350/11-02-0985-OA.1
10.1080/17474086.2016.1245136
10.1172/JCI127195
10.1111/bjh.14478
10.1177/0033354919881438
10.1182/blood-2017-04-590810
10.1136/archdischild-2016-311377
10.1016/j.clp.2015.04.005
10.1016/j.jpedsurg.2017.10.005
10.1097/MOG.0000000000000612
10.1016/j.mrrev.2019.01.002
10.1016/j.pcl.2018.02.005
10.3324/haematol.2013.085522
10.1038/73480
10.1038/sj.leu.2402765
10.1016/j.blre.2019.100589
10.1182/asheducation-2016.1.690
10.1038/gim.2016.173
10.1080/17474086.2019.1662720
10.1002/ajh.25058
10.1056/NEJMoa1806311
10.3324/haematol.2019.232124
10.1002/ncp.10328
ContentType Journal Article
Copyright 2022 American Society of Hematology
2022 by The American Society of Hematology.
2022 by The American Society of Hematology 2022
Copyright_xml – notice: 2022 American Society of Hematology
– notice: 2022 by The American Society of Hematology.
– notice: 2022 by The American Society of Hematology 2022
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1182/blood.2020006479
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

MEDLINE
MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
Anatomy & Physiology
EISSN 1528-0020
EndPage 593
ExternalDocumentID PMC9373018
35213686
10_1182_blood_2020006479
S0006497122002786
Genre Journal Article
GrantInformation_xml – fundername: NCATS NIH HHS
  grantid: UL1 TR001863
– fundername: ;
GroupedDBID ---
-~X
.55
0R~
23N
2WC
34G
39C
4.4
53G
5GY
5RE
5VS
6J9
AAEDW
AAXUO
ABOCM
ACGFO
ADBBV
ADVLN
AENEX
AFETI
AFOSN
AITUG
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
BAWUL
BTFSW
CS3
DIK
DU5
E3Z
EBS
EJD
EX3
F5P
FDB
FRP
GS5
GX1
H13
IH2
K-O
KQ8
L7B
LSO
MJL
N9A
OK1
P2P
R.V
RHI
ROL
SJN
THE
TR2
TWZ
W2D
W8F
WH7
WOQ
WOW
X7M
YHG
YKV
AALRI
AAYXX
ACVFH
ADCNI
AEUPX
AFPUW
AGCQF
AIGII
AKBMS
AKYEP
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
EFKBS
ID FETCH-LOGICAL-c447t-a5ecef22bfbf321765ab00a280345f54808c92602f127351f6d9e8d485c3ba3c3
ISSN 0006-4971
1528-0020
IngestDate Thu Aug 21 18:40:05 EDT 2025
Thu Jul 10 22:45:29 EDT 2025
Thu Apr 03 07:01:05 EDT 2025
Tue Jul 01 04:29:12 EDT 2025
Thu Apr 24 23:04:29 EDT 2025
Sun Apr 06 06:54:20 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
License 2022 by The American Society of Hematology.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c447t-a5ecef22bfbf321765ab00a280345f54808c92602f127351f6d9e8d485c3ba3c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://ashpublications.org/blood/article-pdf/140/6/571/1912940/bloodbld2020006479c.pdf
PMID 35213686
PQID 2633856058
PQPubID 23479
PageCount 23
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9373018
proquest_miscellaneous_2633856058
pubmed_primary_35213686
crossref_citationtrail_10_1182_blood_2020006479
crossref_primary_10_1182_blood_2020006479
elsevier_sciencedirect_doi_10_1182_blood_2020006479
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-08-11
20220811
PublicationDateYYYYMMDD 2022-08-11
PublicationDate_xml – month: 08
  year: 2022
  text: 2022-08-11
  day: 11
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Washington, DC
PublicationTitle Blood
PublicationTitleAlternate Blood
PublicationYear 2022
Publisher Elsevier Inc
American Society of Hematology
Publisher_xml – name: Elsevier Inc
– name: American Society of Hematology
References Avila Bernabeu, Cavero Escribano, Cao Vilarino (bib21) 2020; 144
Seu, Trump, Emberesh (bib108) 2020; 107
Joly, Coppo, Veyradier (bib22) 2018; 101
Grace, Bianchi, van Beers (bib14) 2018; 131
Baker, Greer, Committee on Nutrition American Academy of Pediatrics (bib50) 2010; 126
Aydogan, Keskin, Akici (bib60) 2019; 41
Piel, Weatherall (bib66) 2014; 371
Watanabe (bib109) 2019; 61
Gallagher, Maksimova, Lezon-Geyda (bib10) 2019; 129
Spinale, Ruebner, Kaplan, Copelovitch (bib44) 2013; 25
El Raziky, Ali, El Shahawy, Hamdy (bib30) 2014; 36
Stoopler, Shanti (bib94) 2019; 94
De Andrade Cairo, Rodrigues Silva, Carneiro Bustani, Ferreira Marques (bib55) 2014; 29
Camaschella, Nai, Silvestri (bib57) 2020; 105
Bartels, Bierings (bib87) 2019; 184
Walsh, Johnson (bib19) 2018; 103
Piel (bib64) 2016; 30
Fermo, Vercellati, Marcello (bib7) 2021; 12
Sankaran, Rodriguez, Jacob, Kreuter, Go (bib39) 2016; 38
Asadov, Alimirzoeva, Mammadova, Aliyeva, Gafarova, Mammadov (bib74) 2018; 108
Shteyer, Saada, Shaag (bib107) 2009; 84
Kremer Hovinga, Coppo, Lämmle, Moake, Miyata, Vanhoorelbeke (bib23) 2017; 3
Ulirsch, Verboon, Kazerounian (bib86) 2018; 103
Taher A, Vichinsky E, Musallam K, Cappellini MD, Viprakasit V,. In: Weatherall D, ed. Guidelines for the management of non transfusion dependent thalassaemia (NTDT). Nicosia (Cyprus): Thalassaemia International Federation; 2013.
Wallace, Harris, Addison, Bean (bib28) 2018; 19
Aladjidi, Leverger, Leblanc, Centre de Référence National des Cytopénies Auto-immunes de l'Enfant (CEREVANCE) (bib35) 2011; 96
Tribolet, Hoyoux, Boon (bib17) 2019; 26
Songdej, Babbs, Higgs, BHFS International Consortium (bib69) 2017; 129
Hendrickson, Delaney (bib33) 2016; 30
Gambale, Iolascon, Andolfo, Russo (bib100) 2016; 9
(bib59) 2016; 138
Bezzerri, Cipolli (bib91) 2019; 23
Siddiqui, Journeycake, Borogovac, George (bib24) 2021; 68
Even-Or, Stepensky (bib111) 2021; 68
Kamesaki, Kajii (bib37) 2018; 140
Kruizinga, van Tol, Bekker (bib41) 2018; 24
Powers, Buchanan, Adix, Zhang, Gao, McCavit (bib54) 2017; 317
Sankaran, Gallagher (bib9) 2013; 122
Myint, Oo, Thein, Tun, Saeed (bib119) 2018; 97
Fucharoen, Viprakasit (bib70) 2009
Luzzatto, Ally, Notaro (bib13) 2020; 136
Thornburg, Ware (bib81) 2018; 65
Khincha, Savage (bib93) 2016; 21
Saarinen, Siimes (bib121) 1978; 92
Schoettler, Nathan (bib97) 2018; 32
Ocas-Córdova, Tapia, Gonzales (bib4) 2018; 19
Fernando, van Mourik, Wassmer, Kelly (bib29) 2020; 105
Romero-Cortadellas, Hernéandez, Xèenia (bib104) 2021; 138(suppl 1). Abstract
Hoppe, Neumayr (bib82) 2019; 33
Russo, Andolfo, Manna (bib8) 2018; 93
Hill, DeZern, Kinoshita, Brodsky (bib27) 2017; 3
Hasle, Niemeyer (bib114) 2011; 154
Pecker, Schaefer, Luchtman-Jones (bib83) 2017; 176
Timmer, Tanck, Huis In 't Veld (bib5) 2019; 779
Zierk, Hirschmann, Toddenroth (bib2) 2019; 57
Fouquet, Le Rouzic, Leblanc (bib62) 2019; 187
Roy, Babbs (bib101) 2019; 185
Manrique-Caballero, Peerapornratana, Formeck, Del Rio-Pertuz, Gomez Danies, Kellum (bib20) 2020; 36
Fiesco-Roa, Giri, McReynolds, Best, Alter (bib89) 2019; 37
Altarelli, Ben-Hamouda, Schneider, Berger (bib117) 2019; 34
(bib51) 2007; 12
Kalle Kwaifa, Lai, Md Noor (bib67) 2020; 15
Chaparro, Suchdev (bib1) 2019; 1450
Hill, Stamps, Massey, Grainger, Provan, Hill, British Society for Haematology (bib34) 2017; 176
Go, Winters, Kay (bib38) 2017; 129
Yoshida, Kojima (bib98) 2018; 20
Zemrani, Bines (bib118) 2020; 36
Gallagher (bib12) 2017; 130
Wild, Goldstein, Muraresku, Ganetzky (bib96) 2020; 182
Cao, Galanello (bib73) 2010; 12
Nalepa, Clapp (bib90) 2018; 18
Satchwell, Pellegrin, Bianchi (bib102) 2013; 98
Hasle, Niemeyer, Chessells (bib112) 2003; 17
Conley, Lippman, Ness, Petz, Branch, Gallagher (bib32) 1982; 306
Repnikova, Roberts, Mc Dermott (bib71) 2019; 215
McCann, Perapoch Amadó, Moore (bib49) 2020; 12
Camaschella (bib48) 2015; 372
Liljeholm, Irvine, Vikberg (bib103) 2013; 121
Kalfa (bib40) 2016; 2016
Pasricha, Tye-Dine, Muckenthaler, Swinkels (bib120) 2021; 397
Muis, Beemer, van Dijken, Klep-de Pater (bib88) 1986; 145
Pasricha, Tye-Din, Muckenthaler, Swinkels (bib53) 2021; 397
Nichols, Crispino, Poncz (bib105) 2000; 24
Myers, Furutani, Weller (bib92) 2020; 7
Notrica, Sayrs, Bhatia (bib43) 2018; 53
Leung, Leung, Lau, Tang, Chan (bib68) 2008; 13
Teti, Teitelbaum (bib110) 2019; 119
Gallagher (bib16) 2015; 2015
Locatelli, Strahm (bib113) 2018; 131
Henry, Christensen (bib3) 2015; 42
Fucharoen, Weatherall (bib78) 2012; 2
Weiss, Ganz, Goodnough (bib56) 2019; 133
Socha, DeSouza, Flagg, Sekeres, Rogers (bib85) 2020; 87
Origa (bib65) 2017; 19
Rogers, Nakano, Olson (bib99) 2019; 104
Borgna-Pignatti, Zanella (bib52) 2016; 9
Burns, Woodward (bib47) 2019; 35
Yaralı, Bilir, Erdem, Çulha, Kara, Özbek (bib36) 2018; 57
van den Heuvel-Eibrink (bib26) 2007; 9
Schwartz, Ma, Lamprecht (bib115) 2017; 8
Moh-Klaren, Bodivit, Jugie (bib45) 2017; 57
Green, Allen, Bjørke-Monsen (bib84) 2017; 3
Hill, Stamps, Massey, Grainger, Provan, Hill, British Society for Haematology Guidelines (bib42) 2017; 177
Khandros, Kwiatkowski (bib77) 2019; 33
Bollekens, Forget (bib72) 1991; 5
Piel, Steinberg, Rees (bib80) 2017; 376
Grace, Glader (bib15) 2018; 65
Abu-Zeinah, DeSancho (bib61) 2020; 11
Steiner, Ehrenkranz, Peterec, Steiner, Reyes-Múgica, Gallagher (bib106) 2011; 14
Ducamp, Fleming (bib63) 2019; 133
Lee, Smith-Whitley, Banks, Puckrein (bib79) 2019; 134
Narla, Mohandas (bib11) 2017; 39
Ganz (bib46) 2019; 381
Niewisch, Savage (bib95) 2019; 12
Metivier, Marchais, Guerin, Pannier, London (bib6) 2000; 15
Flegel (bib31) 2015; 55(suppl 2
Scully, Cataland, Peyvandi, HERCULES Investigators (bib25) 2019; 380
Taher, Musallam, Karimi (bib76) 2010; 8
Adams, Ricci (bib18) 2019; 33
Landry (bib116) 2016; 4
Pagani, Nai, Silvestri, Camaschella (bib58) 2019; 10
Conley (2022081115223122700_B32) 1982; 306
Kamesaki (2022081115223122700_B37) 2018; 140
Schwartz (2022081115223122700_B115) 2017; 8
Adams (2022081115223122700_B18) 2019; 33
Luzzatto (2022081115223122700_B13) 2020; 136
Nalepa (2022081115223122700_B90) 2018; 18
Thornburg (2022081115223122700_B81) 2018; 65
Hoppe (2022081115223122700_B82) 2019; 33
Saarinen (2022081115223122700_B121) 1978; 92
Russo (2022081115223122700_B8) 2018; 93
Pecker (2022081115223122700_B83) 2017; 176
Weiss (2022081115223122700_B56) 2019; 133
Socha (2022081115223122700_B85) 2020; 87
Myers (2022081115223122700_B92) 2020; 7
Bollekens (2022081115223122700_B72) 1991; 5
Watanabe (2022081115223122700_B109) 2019; 61
(2022081115223122700_B51) 2007; 12
Origa (2022081115223122700_B65) 2017; 19
Avila Bernabeu (2022081115223122700_B21) 2020; 144
Aladjidi (2022081115223122700_B35) 2011; 96
Liljeholm (2022081115223122700_B103) 2013; 121
Ducamp (2022081115223122700_B63) 2019; 133
Pasricha (2022081115223122700_B53) 2021; 397
Borgna-Pignatti (2022081115223122700_B52) 2016; 9
Bartels (2022081115223122700_B87) 2019; 184
Teti (2022081115223122700_B110) 2019; 119
Pagani (2022081115223122700_B58) 2019; 10
Baker (2022081115223122700_B50) 2010; 126
Khincha (2022081115223122700_B93) 2016; 21
Hasle (2022081115223122700_B114) 2011; 154
Hill (2022081115223122700_B42) 2017; 177
Roy (2022081115223122700_B101) 2019; 185
Kruizinga (2022081115223122700_B41) 2018; 24
Romero-Cortadellas (2022081115223122700_B104) 2021; 138(suppl 1). Abstract
Go (2022081115223122700_B38) 2017; 129
Landry (2022081115223122700_B116) 2016; 4
Walsh (2022081115223122700_B19) 2018; 103
Siddiqui (2022081115223122700_B24) 2021; 68
Hasle (2022081115223122700_B112) 2003; 17
Piel (2022081115223122700_B66) 2014; 371
Camaschella (2022081115223122700_B48) 2015; 372
McCann (2022081115223122700_B49) 2020; 12
Seu (2022081115223122700_B108) 2020; 107
Joly (2022081115223122700_B22) 2018; 101
Steiner (2022081115223122700_B106) 2011; 14
Wallace (2022081115223122700_B28) 2018; 19
Repnikova (2022081115223122700_B71) 2019; 215
Rogers (2022081115223122700_B99) 2019; 104
Even-Or (2022081115223122700_B111) 2021; 68
Abu-Zeinah (2022081115223122700_B61) 2020; 11
Gallagher (2022081115223122700_B12) 2017; 130
Piel (2022081115223122700_B64) 2016; 30
Henry (2022081115223122700_B3) 2015; 42
Bezzerri (2022081115223122700_B91) 2019; 23
Hill (2022081115223122700_B27) 2017; 3
Metivier (2022081115223122700_B6) 2000; 15
Scully (2022081115223122700_B25) 2019; 380
Notrica (2022081115223122700_B43) 2018; 53
Spinale (2022081115223122700_B44) 2013; 25
Altarelli (2022081115223122700_B117) 2019; 34
Yaralı (2022081115223122700_B36) 2018; 57
Khandros (2022081115223122700_B77) 2019; 33
Gambale (2022081115223122700_B100) 2016; 9
Muis (2022081115223122700_B88) 1986; 145
Manrique-Caballero (2022081115223122700_B20) 2020; 36
Shteyer (2022081115223122700_B107) 2009; 84
Kalle Kwaifa (2022081115223122700_B67) 2020; 15
Schoettler (2022081115223122700_B97) 2018; 32
Fernando (2022081115223122700_B29) 2020; 105
Wild (2022081115223122700_B96) 2020; 182
Sankaran (2022081115223122700_B39) 2016; 38
Fucharoen (2022081115223122700_B78) 2012; 2
Fermo (2022081115223122700_B7) 2021; 12
Powers (2022081115223122700_B54) 2017; 317
Hill (2022081115223122700_B34) 2017; 176
Hendrickson (2022081115223122700_B33) 2016; 30
Piel (2022081115223122700_B80) 2017; 376
Locatelli (2022081115223122700_B113) 2018; 131
Zierk (2022081115223122700_B2) 2019; 57
Sankaran (2022081115223122700_B9) 2013; 122
Green (2022081115223122700_B84) 2017; 3
Taher (2022081115223122700_B75) 2013
Leung (2022081115223122700_B68) 2008; 13
Fouquet (2022081115223122700_B62) 2019; 187
El Raziky (2022081115223122700_B30) 2014; 36
Gallagher (2022081115223122700_B16) 2015; 2015
Camaschella (2022081115223122700_B57) 2020; 105
Zemrani (2022081115223122700_B118) 2020; 36
Kalfa (2022081115223122700_B40) 2016; 2016
Kremer Hovinga (2022081115223122700_B23) 2017; 3
(2022081115223122700_B59) 2016; 138
Songdej (2022081115223122700_B69) 2017; 129
De Andrade Cairo (2022081115223122700_B55) 2014; 29
Aydogan (2022081115223122700_B60) 2019; 41
Ocas-Córdova (2022081115223122700_B4) 2018; 19
Myint (2022081115223122700_B119) 2018; 97
Chaparro (2022081115223122700_B1) 2019; 1450
Stoopler (2022081115223122700_B94) 2019; 94
Ganz (2022081115223122700_B46) 2019; 381
Lee (2022081115223122700_B79) 2019; 134
Tribolet (2022081115223122700_B17) 2019; 26
Flegel (2022081115223122700_B31) 2015; 55(suppl 2
Fiesco-Roa (2022081115223122700_B89) 2019; 37
Niewisch (2022081115223122700_B95) 2019; 12
Burns (2022081115223122700_B47) 2019; 35
Timmer (2022081115223122700_B5) 2019; 779
Moh-Klaren (2022081115223122700_B45) 2017; 57
Taher (2022081115223122700_B76) 2010; 8
Yoshida (2022081115223122700_B98) 2018; 20
van den Heuvel-Eibrink (2022081115223122700_B26) 2007; 9
Gallagher (2022081115223122700_B10) 2019; 129
Nichols (2022081115223122700_B105) 2000; 24
Narla (2022081115223122700_B11) 2017; 39
Satchwell (2022081115223122700_B102) 2013; 98
Pasricha (2022081115223122700_B120) 2021; 397
Ulirsch (2022081115223122700_B86) 2018; 103
Grace (2022081115223122700_B14) 2018; 131
Cao (2022081115223122700_B73) 2010; 12
Asadov (2022081115223122700_B74) 2018; 108
Fucharoen (2022081115223122700_B70) 2009
Grace (2022081115223122700_B15) 2018; 65
References_xml – volume: 68
  start-page: e28841
  year: 2021
  ident: bib111
  article-title: How we approach malignant infantile osteopetrosis
  publication-title: Pediatr Blood Cancer.
– volume: 94
  start-page: 1668
  year: 2019
  end-page: 1669
  ident: bib94
  article-title: Dyskeratosis congenita
  publication-title: Mayo Clin Proc.
– volume: 11
  start-page: 305
  year: 2020
  end-page: 318
  ident: bib61
  article-title: Understanding sideroblastic anemia: an overview of genetics, epidemiology, pathophysiology and current therapeutic options
  publication-title: J Blood Med.
– volume: 8
  start-page: 1557
  year: 2017
  ident: bib115
  article-title: The genomic landscape of pediatric myelodysplastic syndromes
  publication-title: Nat Commun.
– volume: 380
  start-page: 335
  year: 2019
  end-page: 346
  ident: bib25
  article-title: Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura
  publication-title: N Engl J Med.
– start-page: 26
  year: 2009
  end-page: 34
  ident: bib70
  article-title: Hb H disease: clinical course and disease modifiers
  publication-title: Hematology Am Soc Hematol Educ Program.
– volume: 12
  start-page: 684569
  year: 2021
  ident: bib7
  article-title: Targeted next generation sequencing and diagnosis of congenital hemolytic anemias: a three years experience monocentric study
  publication-title: Front Physiol.
– volume: 134
  start-page: 599
  year: 2019
  end-page: 607
  ident: bib79
  article-title: Reducing health care disparities in sickle cell disease: a review
  publication-title: Public Health Rep.
– volume: 397
  start-page: 233
  year: 2021
  end-page: 248
  ident: bib53
  article-title: Iron deficiency
  publication-title: Lancet.
– volume: 133
  start-page: 59
  year: 2019
  end-page: 69
  ident: bib63
  article-title: The molecular genetics of sideroblastic anemia
  publication-title: Blood.
– volume: 317
  start-page: 2297
  year: 2017
  end-page: 2304
  ident: bib54
  article-title: Effect of low-dose ferrous sulfate vs iron polysaccharide complex on hemoglobin concentration in young children with nutritional iron-deficiency anemia: a randomized clinical trial
  publication-title: JAMA.
– volume: 14
  start-page: 301
  year: 2011
  end-page: 306
  ident: bib106
  article-title: Perinatal onset mevalonate kinase deficiency
  publication-title: Pediatr Dev Pathol.
– volume: 26
  start-page: 365
  year: 2019
  end-page: 369
  ident: bib17
  article-title: A not so harmless mass: kaposiform hemangioendothelioma complicated by a Kasabach-Merritt phenomenon
  publication-title: Arch Pediatr.
– volume: 12
  start-page: 61
  year: 2010
  end-page: 76
  ident: bib73
  article-title: Beta-thalassemia
  publication-title: Genet Med.
– volume: 87
  start-page: 153
  year: 2020
  end-page: 164
  ident: bib85
  article-title: Severe megaloblastic anemia: vitamin deficiency and other causes
  publication-title: Cleve Clin J Med.
– volume: 129
  start-page: 2878
  year: 2019
  end-page: 2887
  ident: bib10
  article-title: Aberrant splicing contributes to severe α-spectrin-linked congenital hemolytic anemia
  publication-title: J Clin Invest.
– volume: 215
  start-page: 152578
  year: 2019
  ident: bib71
  article-title: Clinical and molecular characterization of novel deletions causing epsilon gamma delta beta thalassemia: Report of two cases
  publication-title: Pathol Res Pract.
– volume: 138(suppl 1). Abstract
  start-page: 847
  year: 2021
  ident: bib104
  article-title: Autosomal recessive congenital dyserythropoietic anemia type III is caused by mutations in the centralspindlin RACGAP1 component [abstract]
  publication-title: Blood.
– volume: 97
  start-page: 1527
  year: 2018
  end-page: 1534
  ident: bib119
  article-title: Copper deficiency anemia: review article
  publication-title: Ann Hematol.
– volume: 12
  start-page: 2001
  year: 2020
  ident: bib49
  article-title: The Role of iron in brain development: a systematic review
  publication-title: Nutrients.
– volume: 140
  start-page: 10
  year: 2018
  end-page: 17
  ident: bib37
  article-title: A comprehensive diagnostic algorithm for direct antiglobulin test-negative autoimmune hemolytic anemia reveals the relative ratio of three mechanisms in a single laboratory
  publication-title: Acta Haematol.
– volume: 5
  start-page: 399
  year: 1991
  end-page: 422
  ident: bib72
  article-title: Delta beta thalassemia and hereditary persistence of fetal hemoglobin
  publication-title: Hematol Oncol Clin North Am.
– volume: 779
  start-page: 58
  year: 2019
  end-page: 67
  ident: bib5
  article-title: Associations between single nucleotide polymorphisms and erythrocyte parameters in humans: a systematic literature review
  publication-title: Mutat Res Rev Mutat Res.
– volume: 184
  start-page: 123
  year: 2019
  end-page: 133
  ident: bib87
  article-title: How I manage children with diamond-blackfan anaemia
  publication-title: Br J Haematol.
– volume: 23
  start-page: 281
  year: 2019
  end-page: 290
  ident: bib91
  article-title: Shwachman-Diamond syndrome: molecular mechanisms and current perspectives
  publication-title: Mol Diagn Ther.
– volume: 371
  start-page: 1908
  year: 2014
  end-page: 1916
  ident: bib66
  article-title: The α-thalassemias
  publication-title: N Engl J Med.
– volume: 55(suppl 2
  start-page: S47
  year: 2015
  end-page: S58
  ident: bib31
  article-title: Pathogenesis and mechanisms of antibody-mediated hemolysis
  publication-title: Transfusion.
– volume: 33
  start-page: 455
  year: 2019
  end-page: 470
  ident: bib18
  article-title: Vascular anomalies: diagnosis of complicated anomalies and new medical treatment options
  publication-title: Hematol Oncol Clin North Am.
– volume: 177
  start-page: 208
  year: 2017
  end-page: 220
  ident: bib42
  article-title: Guidelines on the management of drug-induced immune and secondary autoimmune, haemolytic anaemia
  publication-title: Br J Haematol.
– volume: 57
  start-page: 2571
  year: 2017
  end-page: 2577
  ident: bib45
  article-title: Severe hemolysis after plasma transfusion in a neonate with necrotizing enterocolitis, Clostridium perfringens infection, and red blood cell T-polyagglutination
  publication-title: Transfusion.
– volume: 18
  start-page: 168
  year: 2018
  end-page: 185
  ident: bib90
  article-title: Fanconi anaemia and cancer: an intricate relationship
  publication-title: Nat Rev Cancer.
– volume: 144
  start-page: 537
  year: 2020
  end-page: 549
  ident: bib21
  article-title: Atypical hemolytic uremic syndrome: new challenges in the complement blockage era
  publication-title: Nephron.
– volume: 12
  start-page: 1037
  year: 2019
  end-page: 1052
  ident: bib95
  article-title: An update on the biology and management of dyskeratosis congenita and related telomere biology disorders
  publication-title: Expert Rev Hematol.
– volume: 126
  start-page: 1040
  year: 2010
  end-page: 1050
  ident: bib50
  article-title: Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age)
  publication-title: Pediatrics.
– volume: 3
  start-page: 17040
  year: 2017
  ident: bib84
  article-title: Vitamin B
  publication-title: Nat Rev Dis Primers.
– volume: 19
  start-page: 609
  year: 2017
  end-page: 619
  ident: bib65
  article-title: β-Thalassemia
  publication-title: Genet Med.
– volume: 35
  start-page: 237
  year: 2019
  end-page: 240
  ident: bib47
  article-title: Transient erythroblastopenia of childhood: a review for the pediatric emergency medicine physician
  publication-title: Pediatr Emerg Care.
– volume: 15
  start-page: 14
  year: 2000
  end-page: 18
  ident: bib6
  article-title: Pathophysiology of anaemia: focus on the heart and blood vessels
  publication-title: Nephrol Dial Transplant.
– volume: 25
  start-page: 203
  year: 2013
  end-page: 208
  ident: bib44
  article-title: Update on Streptococcus pneumoniae associated hemolytic uremic syndrome
  publication-title: Curr Opin Pediatr.
– volume: 187
  start-page: 530
  year: 2019
  end-page: 542
  ident: bib62
  article-title: Genotype/phenotype correlations of childhood-onset congenital sideroblastic anaemia in a European cohort
  publication-title: Br J Haematol.
– volume: 104
  start-page: 1974
  year: 2019
  end-page: 1983
  ident: bib99
  article-title: Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study
  publication-title: Haematologica.
– volume: 36
  start-page: 333
  year: 2020
  end-page: 356
  ident: bib20
  article-title: Typical and atypical hemolytic uremic syndrome in the critically ill
  publication-title: Crit Care Clin.
– volume: 108
  start-page: 5
  year: 2018
  end-page: 21
  ident: bib74
  article-title: β-Thalassemia intermedia: a comprehensive overview and novel approaches
  publication-title: Int J Hematol.
– volume: 105
  start-page: 499
  year: 2020
  end-page: 505
  ident: bib29
  article-title: Wilson disease in children and adolescents
  publication-title: Arch Dis Child.
– volume: 24
  start-page: 772
  year: 2018
  end-page: 778
  ident: bib41
  article-title: Risk Factors, Treatment, and Immune Dysregulation in Autoimmune Cytopenia after Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients
  publication-title: Biol Blood Marrow Transplant.
– volume: 154
  start-page: 185
  year: 2011
  end-page: 195
  ident: bib114
  article-title: Advances in the prognostication and management of advanced MDS in children
  publication-title: Br J Haematol.
– volume: 131
  start-page: 1406
  year: 2018
  end-page: 1414
  ident: bib113
  article-title: How I treat myelodysplastic syndromes of childhood
  publication-title: Blood.
– volume: 57
  start-page: 1595
  year: 2019
  end-page: 1607
  ident: bib2
  article-title: Next-generation reference intervals for pediatric hematology
  publication-title: Clin Chem Lab Med.
– volume: 20
  start-page: 67
  year: 2018
  ident: bib98
  article-title: Updated guidelines for the treatment of acquired aplastic anemia in children
  publication-title: Curr Oncol Rep.
– volume: 24
  start-page: 266
  year: 2000
  end-page: 270
  ident: bib105
  article-title: Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
  publication-title: Nat Genet.
– volume: 30
  start-page: 159
  year: 2016
  end-page: 164
  ident: bib33
  article-title: Hemolytic disease of the fetus and newborn: modern practice and future investigations
  publication-title: Transfus Med Rev.
– volume: 13
  start-page: 215
  year: 2008
  end-page: 222
  ident: bib68
  article-title: Alpha-thalassaemia
  publication-title: Semin Fetal Neonatal Med.
– volume: 376
  start-page: 1561
  year: 2017
  end-page: 1573
  ident: bib80
  article-title: Sickle cell disease
  publication-title: N Engl J Med.
– volume: 130
  start-page: 2699
  year: 2017
  end-page: 2708
  ident: bib12
  article-title: Disorders of erythrocyte hydration
  publication-title: Blood.
– volume: 372
  start-page: 1832
  year: 2015
  end-page: 1843
  ident: bib48
  article-title: Iron-deficiency anemia
  publication-title: N Engl J Med.
– volume: 68
  start-page: e28949
  year: 2021
  ident: bib24
  article-title: Recognizing and managing hereditary and acquired thrombotic thrombocytopenic purpura in infants and children
  publication-title: Pediatr Blood Cancer.
– volume: 96
  start-page: 655
  year: 2011
  end-page: 663
  ident: bib35
  article-title: New insights into childhood autoimmune hemolytic anemia: a French national observational study of 265 children
  publication-title: Haematologica.
– reference: Taher A, Vichinsky E, Musallam K, Cappellini MD, Viprakasit V,. In: Weatherall D, ed. Guidelines for the management of non transfusion dependent thalassaemia (NTDT). Nicosia (Cyprus): Thalassaemia International Federation; 2013.
– volume: 65
  start-page: e27000
  year: 2018
  ident: bib81
  article-title: Children with sickle cell disease migrating to the United States from sub-Saharan Africa
  publication-title: Pediatr Blood Cancer.
– volume: 2
  start-page: a011734
  year: 2012
  ident: bib78
  article-title: The hemoglobin E thalassemias
  publication-title: Cold Spring Harb Perspect Med.
– volume: 33
  start-page: 355
  year: 2019
  end-page: 371
  ident: bib82
  article-title: Sickle cell disease: monitoring, current treatment, and therapeutics under development
  publication-title: Hematol Oncol Clin North Am.
– volume: 65
  start-page: 579
  year: 2018
  end-page: 595
  ident: bib15
  article-title: Red blood cell enzyme disorders
  publication-title: Pediatr Clin North Am.
– volume: 19
  start-page: 816
  year: 2018
  end-page: 826
  ident: bib28
  article-title: HELLP syndrome: pathophysiology and current therapies
  publication-title: Curr Pharm Biotechnol.
– volume: 397
  start-page: 233
  year: 2021
  end-page: 248
  ident: bib120
  article-title: Iron deficiency
  publication-title: Lancet.
– volume: 136
  start-page: 1225
  year: 2020
  end-page: 1240
  ident: bib13
  article-title: Glucose-6-phosphate dehydrogenase deficiency
  publication-title: Blood.
– volume: 32
  start-page: 581
  year: 2018
  end-page: 594
  ident: bib97
  article-title: The pathophysiology of acquired aplastic anemia: current concepts revisited
  publication-title: Hematol Oncol Clin North Am.
– volume: 107
  start-page: 1149
  year: 2020
  end-page: 1156
  ident: bib108
  article-title: VPS4A mutations in humans cause syndromic congenital dyserythropoietic anemia due to cytokinesis and trafficking defects
  publication-title: Am J Hum Genet.
– volume: 119
  start-page: 71
  year: 2019
  end-page: 81
  ident: bib110
  article-title: Congenital disorders of bone and blood
  publication-title: Bone.
– volume: 133
  start-page: 40
  year: 2019
  end-page: 50
  ident: bib56
  article-title: Anemia of inflammation
  publication-title: Blood.
– volume: 15
  start-page: 166
  year: 2020
  ident: bib67
  article-title: Non-deletional alpha thalassaemia: a review
  publication-title: Orphanet J Rare Dis.
– volume: 2015
  start-page: 392
  year: 2015
  end-page: 399
  ident: bib16
  article-title: Diagnosis and management of rare congenital nonimmune hemolytic disease
  publication-title: Hematology Am Soc Hematol Educ Program.
– volume: 101
  start-page: 425
  year: 2018
  end-page: 434
  ident: bib22
  article-title: Pediatric thrombotic thrombocytopenic purpura
  publication-title: Eur J Haematol.
– volume: 19
  start-page: 398
  year: 2018
  end-page: 403
  ident: bib4
  article-title: Hemoglobin concentration in children at different altitudes in Peru: proposal for [Hb] correction for altitude to diagnose anemia and polycythemia
  publication-title: High Alt Med Biol.
– volume: 103
  start-page: 930
  year: 2018
  end-page: 947
  ident: bib86
  article-title: The genetic landscape of diamond-blackfan anemia [published correction appears in
  publication-title: Am J Hum Genet.
– volume: 37
  start-page: 100589
  year: 2019
  ident: bib89
  article-title: Genotype-phenotype associations in Fanconi anemia: A literature review
  publication-title: Blood Rev.
– volume: 129
  start-page: 2971
  year: 2017
  end-page: 2979
  ident: bib38
  article-title: How I treat autoimmune hemolytic anemia
  publication-title: Blood.
– volume: 129
  start-page: 1251
  year: 2017
  end-page: 1259
  ident: bib69
  article-title: An international registry of survivors with Hb Bart's hydrops fetalis syndrome
  publication-title: Blood.
– volume: 145
  start-page: 153
  year: 1986
  end-page: 157
  ident: bib88
  article-title: The Aase syndrome. Case report and review of the literature
  publication-title: Eur J Pediatr.
– volume: 7
  start-page: e238
  year: 2020
  end-page: e246
  ident: bib92
  article-title: Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study
  publication-title: Lancet Haematol.
– volume: 53
  start-page: 339
  year: 2018
  end-page: 343
  ident: bib43
  article-title: The incidence of delayed splenic bleeding in pediatric blunt trauma
  publication-title: J Pediatr Surg.
– volume: 93
  start-page: 672
  year: 2018
  end-page: 682
  ident: bib8
  article-title: Multi-gene panel testing improves diagnosis and management of patients with hereditary anemias
  publication-title: Am J Hematol.
– volume: 381
  start-page: 1148
  year: 2019
  end-page: 1157
  ident: bib46
  article-title: Anemia of inflammation
  publication-title: N Engl J Med.
– volume: 98
  start-page: 1788
  year: 2013
  end-page: 1796
  ident: bib102
  article-title: Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis
  publication-title: Haematologica.
– volume: 122
  start-page: 3575
  year: 2013
  end-page: 3582
  ident: bib9
  article-title: Applications of high-throughput DNA sequencing to benign hematology
  publication-title: Blood.
– volume: 10
  start-page: 1294
  year: 2019
  ident: bib58
  article-title: Hepcidin and anemia: a tight relationship
  publication-title: Front Physiol.
– volume: 9
  start-page: 11
  year: 2007
  end-page: 16
  ident: bib26
  article-title: Paroxysmal nocturnal hemoglobinuria in children
  publication-title: Paediatr Drugs.
– volume: 42
  start-page: 483
  year: 2015
  end-page: 497
  ident: bib3
  article-title: Reference intervals in neonatal hematology
  publication-title: Clin Perinatol.
– volume: 306
  start-page: 281
  year: 1982
  end-page: 286
  ident: bib32
  article-title: Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow
  publication-title: N Engl J Med.
– volume: 176
  start-page: 515
  year: 2017
  end-page: 526
  ident: bib83
  article-title: Knowledge insufficient: the management of haemoglobin SC disease
  publication-title: Br J Haematol.
– volume: 138
  start-page: e20201014
  year: 2016
  ident: bib59
  article-title: Prevention of childhood lead toxicity
  publication-title: Pediatrics.
– volume: 9
  start-page: 283
  year: 2016
  end-page: 296
  ident: bib100
  article-title: Diagnosis and management of congenital dyserythropoietic anemias
  publication-title: Expert Rev Hematol.
– volume: 4
  year: 2016
  ident: bib116
  article-title: Parvovirus B19
  publication-title: Microbiol Spectr.
– volume: 2016
  start-page: 690
  year: 2016
  end-page: 697
  ident: bib40
  article-title: Warm antibody autoimmune hemolytic anemia
  publication-title: Hematology (Am Soc Hematol Educ Program).
– volume: 92
  start-page: 412
  year: 1978
  end-page: 416
  ident: bib121
  article-title: Developmental changes in red blood cell counts and indices of infants after exclusion of iron deficiency by laboratory criteria and continuous iron supplementation
  publication-title: J Pediatr.
– volume: 176
  start-page: 395
  year: 2017
  end-page: 411
  ident: bib34
  article-title: The diagnosis and management of primary autoimmune haemolytic anaemia
  publication-title: Br J Haematol.
– volume: 57
  start-page: 665
  year: 2018
  end-page: 668
  ident: bib36
  article-title: Clinical features and treatment of primary autoimmune hemolytic anemia in childhood
  publication-title: Transfus Apheresis Sci.
– volume: 121
  start-page: 4791
  year: 2013
  end-page: 4799
  ident: bib103
  article-title: Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23
  publication-title: Blood.
– volume: 84
  start-page: 412
  year: 2009
  end-page: 417
  ident: bib107
  article-title: Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene
  publication-title: Am J Hum Genet.
– volume: 17
  start-page: 277
  year: 2003
  end-page: 278
  ident: bib112
  article-title: A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases
  publication-title: Leukemia.
– volume: 36
  start-page: 110
  year: 2020
  end-page: 117
  ident: bib118
  article-title: Recent insights into trace element deficiencies: causes, recognition and correction
  publication-title: Curr Opin Gastroenterol.
– volume: 9
  start-page: 1075
  year: 2016
  end-page: 1080
  ident: bib52
  article-title: Pica as a manifestation of iron deficiency
  publication-title: Expert Rev Hematol.
– volume: 29
  start-page: 1240
  year: 2014
  end-page: 1249
  ident: bib55
  article-title: Iron deficiency anemia in adolescents; a literature review
  publication-title: Nutr Hosp.
– volume: 8
  start-page: 2152
  year: 2010
  end-page: 2158
  ident: bib76
  article-title: Splenectomy and thrombosis: the case of thalassemia intermedia
  publication-title: J Thromb Haemost.
– volume: 3
  start-page: 17028
  year: 2017
  ident: bib27
  article-title: Paroxysmal nocturnal haemoglobinuria
  publication-title: Nat Rev Dis Primers.
– volume: 103
  start-page: 285
  year: 2018
  end-page: 291
  ident: bib19
  article-title: Treatment and management of children with haemolytic uraemic syndrome
  publication-title: Arch Dis Child.
– volume: 36
  start-page: 173
  year: 2014
  end-page: 178
  ident: bib30
  article-title: Acute hemolytic anemia as an initial presentation of Wilson disease in children
  publication-title: J Pediatr Hematol Oncol.
– volume: 61
  start-page: 222
  year: 2019
  end-page: 229
  ident: bib109
  article-title: Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome
  publication-title: Pediatr Int (Roma).
– volume: 38
  start-page: e120
  year: 2016
  end-page: e124
  ident: bib39
  article-title: Autoimmune hemolytic anemia in children: Mayo Clinic experience
  publication-title: J Pediatr Hematol Oncol.
– volume: 185
  start-page: 436
  year: 2019
  end-page: 449
  ident: bib101
  article-title: The pathogenesis, diagnosis and management of congenital dyserythropoietic anaemia type I
  publication-title: Br J Haematol.
– volume: 30
  start-page: 327
  year: 2016
  end-page: 341
  ident: bib64
  article-title: The present and future global burden of the inherited disorders of hemoglobin
  publication-title: Hematol Oncol Clin North Am.
– volume: 34
  start-page: 504
  year: 2019
  end-page: 513
  ident: bib117
  article-title: Copper deficiency: causes, manifestations, and treatment
  publication-title: Nutr Clin Pract.
– volume: 33
  start-page: 339
  year: 2019
  end-page: 353
  ident: bib77
  article-title: Beta thalassemia: monitoring and new treatment approaches
  publication-title: Hematol Oncol Clin North Am.
– volume: 21
  start-page: 57
  year: 2016
  end-page: 65
  ident: bib93
  article-title: Neonatal manifestations of inherited bone marrow failure syndromes
  publication-title: Semin Fetal Neonatal Med.
– volume: 39
  start-page: 47
  year: 2017
  end-page: 52
  ident: bib11
  article-title: Red cell membrane disorders
  publication-title: Int J Lab Hematol.
– volume: 1450
  start-page: 15
  year: 2019
  end-page: 31
  ident: bib1
  article-title: Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries
  publication-title: Ann N Y Acad Sci.
– volume: 131
  start-page: 2183
  year: 2018
  end-page: 2192
  ident: bib14
  article-title: Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study
  publication-title: Blood.
– volume: 182
  start-page: 365
  year: 2020
  end-page: 373
  ident: bib96
  article-title: Broadening the phenotypic spectrum of Pearson syndrome: five new cases and a review of the literature
  publication-title: Am J Med Genet A.
– volume: 12
  start-page: 333
  year: 2007
  end-page: 336
  ident: bib51
  article-title: Iron needs of babies and children
  publication-title: Paediatr Child Health.
– volume: 3
  start-page: 17020
  year: 2017
  ident: bib23
  article-title: Thrombotic thrombocytopenic purpura
  publication-title: Nat Rev Dis Primers.
– volume: 41
  start-page: e221
  year: 2019
  end-page: e223
  ident: bib60
  article-title: Causes of hypochromic microcytic anemia in children and evaluation of laboratory parameters in the differentiation
  publication-title: J Pediatr Hematol Oncol.
– volume: 105
  start-page: 260
  year: 2020
  end-page: 272
  ident: bib57
  article-title: Iron metabolism and iron disorders revisited in the hepcidin era
  publication-title: Haematologica.
– volume: 3
  start-page: 17028
  issue: 1
  year: 2017
  ident: 2022081115223122700_B27
  article-title: Paroxysmal nocturnal haemoglobinuria
  publication-title: Nat Rev Dis Primers.
  doi: 10.1038/nrdp.2017.28
– volume: 185
  start-page: 436
  issue: 3
  year: 2019
  ident: 2022081115223122700_B101
  article-title: The pathogenesis, diagnosis and management of congenital dyserythropoietic anaemia type I
  publication-title: Br J Haematol.
  doi: 10.1111/bjh.15817
– volume: 84
  start-page: 412
  issue: 3
  year: 2009
  ident: 2022081115223122700_B107
  article-title: Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene
  publication-title: Am J Hum Genet.
  doi: 10.1016/j.ajhg.2009.02.006
– volume: 5
  start-page: 399
  issue: 3
  year: 1991
  ident: 2022081115223122700_B72
  article-title: Delta beta thalassemia and hereditary persistence of fetal hemoglobin
  publication-title: Hematol Oncol Clin North Am.
  doi: 10.1016/S0889-8588(18)30422-2
– volume: 176
  start-page: 515
  issue: 4
  year: 2017
  ident: 2022081115223122700_B83
  article-title: Knowledge insufficient: the management of haemoglobin SC disease
  publication-title: Br J Haematol.
  doi: 10.1111/bjh.14444
– volume: 129
  start-page: 2971
  issue: 22
  year: 2017
  ident: 2022081115223122700_B38
  article-title: How I treat autoimmune hemolytic anemia
  publication-title: Blood.
  doi: 10.1182/blood-2016-11-693689
– volume: 9
  start-page: 11
  issue: 1
  year: 2007
  ident: 2022081115223122700_B26
  article-title: Paroxysmal nocturnal hemoglobinuria in children
  publication-title: Paediatr Drugs.
  doi: 10.2165/00148581-200709010-00002
– volume: 18
  start-page: 168
  issue: 3
  year: 2018
  ident: 2022081115223122700_B90
  article-title: Fanconi anaemia and cancer: an intricate relationship
  publication-title: Nat Rev Cancer.
  doi: 10.1038/nrc.2017.116
– volume: 97
  start-page: 1527
  issue: 9
  year: 2018
  ident: 2022081115223122700_B119
  article-title: Copper deficiency anemia: review article
  publication-title: Ann Hematol.
  doi: 10.1007/s00277-018-3407-5
– volume: 133
  start-page: 59
  issue: 1
  year: 2019
  ident: 2022081115223122700_B63
  article-title: The molecular genetics of sideroblastic anemia
  publication-title: Blood.
  doi: 10.1182/blood-2018-08-815951
– volume: 103
  start-page: 930
  issue: 6
  year: 2018
  ident: 2022081115223122700_B86
  article-title: The genetic landscape of diamond-blackfan anemia
  publication-title: Am J Hum Genet.
  doi: 10.1016/j.ajhg.2018.10.027
– volume: 24
  start-page: 772
  issue: 4
  year: 2018
  ident: 2022081115223122700_B41
  article-title: Risk Factors, Treatment, and Immune Dysregulation in Autoimmune Cytopenia after Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients
  publication-title: Biol Blood Marrow Transplant.
  doi: 10.1016/j.bbmt.2017.12.782
– volume: 87
  start-page: 153
  issue: 3
  year: 2020
  ident: 2022081115223122700_B85
  article-title: Severe megaloblastic anemia: vitamin deficiency and other causes
  publication-title: Cleve Clin J Med.
  doi: 10.3949/ccjm.87a.19072
– volume: 57
  start-page: 2571
  issue: 11
  year: 2017
  ident: 2022081115223122700_B45
  article-title: Severe hemolysis after plasma transfusion in a neonate with necrotizing enterocolitis, Clostridium perfringens infection, and red blood cell T-polyagglutination
  publication-title: Transfusion.
  doi: 10.1111/trf.14196
– volume: 184
  start-page: 123
  issue: 2
  year: 2019
  ident: 2022081115223122700_B87
  article-title: How I manage children with diamond-blackfan anaemia
  publication-title: Br J Haematol.
  doi: 10.1111/bjh.15701
– volume: 7
  start-page: e238
  issue: 3
  year: 2020
  ident: 2022081115223122700_B92
  article-title: Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study
  publication-title: Lancet Haematol.
  doi: 10.1016/S2352-3026(19)30206-6
– volume: 26
  start-page: 365
  issue: 6
  year: 2019
  ident: 2022081115223122700_B17
  article-title: A not so harmless mass: kaposiform hemangioendothelioma complicated by a Kasabach-Merritt phenomenon
  publication-title: Arch Pediatr.
  doi: 10.1016/j.arcped.2019.06.003
– volume: 177
  start-page: 208
  issue: 2
  year: 2017
  ident: 2022081115223122700_B42
  article-title: Guidelines on the management of drug-induced immune and secondary autoimmune, haemolytic anaemia
  publication-title: Br J Haematol.
  doi: 10.1111/bjh.14654
– volume: 104
  start-page: 1974
  issue: 10
  year: 2019
  ident: 2022081115223122700_B99
  article-title: Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study
  publication-title: Haematologica.
  doi: 10.3324/haematol.2018.206540
– volume: 105
  start-page: 499
  issue: 5
  year: 2020
  ident: 2022081115223122700_B29
  article-title: Wilson disease in children and adolescents
  publication-title: Arch Dis Child.
  doi: 10.1136/archdischild-2018-315705
– volume: 136
  start-page: 1225
  issue: 11
  year: 2020
  ident: 2022081115223122700_B13
  article-title: Glucose-6-phosphate dehydrogenase deficiency
  publication-title: Blood.
  doi: 10.1182/blood.2019000944
– volume: 381
  start-page: 1148
  issue: 12
  year: 2019
  ident: 2022081115223122700_B46
  article-title: Anemia of inflammation
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMra1804281
– volume: 19
  start-page: 816
  issue: 10
  year: 2018
  ident: 2022081115223122700_B28
  article-title: HELLP syndrome: pathophysiology and current therapies
  publication-title: Curr Pharm Biotechnol.
  doi: 10.2174/1389201019666180712115215
– volume: 15
  start-page: 166
  issue: 1
  year: 2020
  ident: 2022081115223122700_B67
  article-title: Non-deletional alpha thalassaemia: a review
  publication-title: Orphanet J Rare Dis.
  doi: 10.1186/s13023-020-01429-1
– volume: 3
  start-page: 17020
  issue: 1
  year: 2017
  ident: 2022081115223122700_B23
  article-title: Thrombotic thrombocytopenic purpura
  publication-title: Nat Rev Dis Primers.
  doi: 10.1038/nrdp.2017.20
– volume: 39
  start-page: 47
  year: 2017
  ident: 2022081115223122700_B11
  article-title: Red cell membrane disorders
  publication-title: Int J Lab Hematol.
  doi: 10.1111/ijlh.12657
– volume: 30
  start-page: 159
  issue: 4
  year: 2016
  ident: 2022081115223122700_B33
  article-title: Hemolytic disease of the fetus and newborn: modern practice and future investigations
  publication-title: Transfus Med Rev.
  doi: 10.1016/j.tmrv.2016.05.008
– volume: 126
  start-page: 1040
  issue: 5
  year: 2010
  ident: 2022081115223122700_B50
  article-title: Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age)
  publication-title: Pediatrics.
  doi: 10.1542/peds.2010-2576
– volume: 38
  start-page: e120
  issue: 3
  year: 2016
  ident: 2022081115223122700_B39
  article-title: Autoimmune hemolytic anemia in children: Mayo Clinic experience
  publication-title: J Pediatr Hematol Oncol.
  doi: 10.1097/MPH.0000000000000542
– volume: 122
  start-page: 3575
  issue: 22
  year: 2013
  ident: 2022081115223122700_B9
  article-title: Applications of high-throughput DNA sequencing to benign hematology
  publication-title: Blood.
  doi: 10.1182/blood-2013-07-460337
– volume: 3
  start-page: 17040
  issue: 1
  year: 2017
  ident: 2022081115223122700_B84
  article-title: Vitamin B12 deficiency
  publication-title: Nat Rev Dis Primers.
  doi: 10.1038/nrdp.2017.40
– volume: 107
  start-page: 1149
  issue: 6
  year: 2020
  ident: 2022081115223122700_B108
  article-title: VPS4A mutations in humans cause syndromic congenital dyserythropoietic anemia due to cytokinesis and trafficking defects
  publication-title: Am J Hum Genet.
  doi: 10.1016/j.ajhg.2020.10.013
– volume: 9
  start-page: 283
  issue: 3
  year: 2016
  ident: 2022081115223122700_B100
  article-title: Diagnosis and management of congenital dyserythropoietic anemias
  publication-title: Expert Rev Hematol.
  doi: 10.1586/17474086.2016.1131608
– volume: 133
  start-page: 40
  issue: 1
  year: 2019
  ident: 2022081115223122700_B56
  article-title: Anemia of inflammation
  publication-title: Blood.
  doi: 10.1182/blood-2018-06-856500
– volume: 19
  start-page: 398
  issue: 4
  year: 2018
  ident: 2022081115223122700_B4
  article-title: Hemoglobin concentration in children at different altitudes in Peru: proposal for [Hb] correction for altitude to diagnose anemia and polycythemia
  publication-title: High Alt Med Biol.
  doi: 10.1089/ham.2018.0032
– volume: 61
  start-page: 222
  issue: 3
  year: 2019
  ident: 2022081115223122700_B109
  article-title: Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome
  publication-title: Pediatr Int (Roma).
  doi: 10.1111/ped.13776
– volume: 101
  start-page: 425
  issue: 4
  year: 2018
  ident: 2022081115223122700_B22
  article-title: Pediatric thrombotic thrombocytopenic purpura
  publication-title: Eur J Haematol.
  doi: 10.1111/ejh.13107
– volume: 12
  start-page: 61
  issue: 2
  year: 2010
  ident: 2022081115223122700_B73
  article-title: Beta-thalassemia
  publication-title: Genet Med.
  doi: 10.1097/GIM.0b013e3181cd68ed
– volume: 2
  start-page: a011734
  issue: 8
  year: 2012
  ident: 2022081115223122700_B78
  article-title: The hemoglobin E thalassemias
  publication-title: Cold Spring Harb Perspect Med.
  doi: 10.1101/cshperspect.a011734
– volume: 397
  start-page: 233
  issue: 10270
  year: 2021
  ident: 2022081115223122700_B53
  article-title: Iron deficiency
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(20)32594-0
– volume: 30
  start-page: 327
  issue: 2
  year: 2016
  ident: 2022081115223122700_B64
  article-title: The present and future global burden of the inherited disorders of hemoglobin
  publication-title: Hematol Oncol Clin North Am.
  doi: 10.1016/j.hoc.2015.11.004
– year: 2013
  ident: 2022081115223122700_B75
– volume: 371
  start-page: 1908
  issue: 20
  year: 2014
  ident: 2022081115223122700_B66
  article-title: The α-thalassemias
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMra1404415
– volume: 2015
  start-page: 392
  year: 2015
  ident: 2022081115223122700_B16
  article-title: Diagnosis and management of rare congenital nonimmune hemolytic disease
  publication-title: Hematology Am Soc Hematol Educ Program.
  doi: 10.1182/asheducation-2015.1.392
– volume: 41
  start-page: e221
  issue: 4
  year: 2019
  ident: 2022081115223122700_B60
  article-title: Causes of hypochromic microcytic anemia in children and evaluation of laboratory parameters in the differentiation
  publication-title: J Pediatr Hematol Oncol.
  doi: 10.1097/MPH.0000000000001382
– start-page: 26
  year: 2009
  ident: 2022081115223122700_B70
  article-title: Hb H disease: clinical course and disease modifiers
  publication-title: Hematology Am Soc Hematol Educ Program.
  doi: 10.1182/asheducation-2009.1.26
– volume: 1450
  start-page: 15
  issue: 1
  year: 2019
  ident: 2022081115223122700_B1
  article-title: Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries
  publication-title: Ann N Y Acad Sci.
  doi: 10.1111/nyas.14092
– volume: 131
  start-page: 2183
  issue: 20
  year: 2018
  ident: 2022081115223122700_B14
  article-title: Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study
  publication-title: Blood.
  doi: 10.1182/blood-2017-10-810796
– volume: 397
  start-page: 233
  issue: 10270
  year: 2021
  ident: 2022081115223122700_B120
  article-title: Iron deficiency
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(20)32594-0
– volume: 11
  start-page: 305
  year: 2020
  ident: 2022081115223122700_B61
  article-title: Understanding sideroblastic anemia: an overview of genetics, epidemiology, pathophysiology and current therapeutic options
  publication-title: J Blood Med.
  doi: 10.2147/JBM.S232644
– volume: 187
  start-page: 530
  issue: 4
  year: 2019
  ident: 2022081115223122700_B62
  article-title: Genotype/phenotype correlations of childhood-onset congenital sideroblastic anaemia in a European cohort
  publication-title: Br J Haematol.
  doi: 10.1111/bjh.16100
– volume: 57
  start-page: 1595
  issue: 10
  year: 2019
  ident: 2022081115223122700_B2
  article-title: Next-generation reference intervals for pediatric hematology
  publication-title: Clin Chem Lab Med.
  doi: 10.1515/cclm-2018-1236
– volume: 4
  issue: 3
  year: 2016
  ident: 2022081115223122700_B116
  article-title: Parvovirus B19
  publication-title: Microbiol Spectr.
  doi: 10.1128/microbiolspec.DMIH2-0008-2015
– volume: 25
  start-page: 203
  issue: 2
  year: 2013
  ident: 2022081115223122700_B44
  article-title: Update on Streptococcus pneumoniae associated hemolytic uremic syndrome
  publication-title: Curr Opin Pediatr.
  doi: 10.1097/MOP.0b013e32835d7f2c
– volume: 33
  start-page: 455
  issue: 3
  year: 2019
  ident: 2022081115223122700_B18
  article-title: Vascular anomalies: diagnosis of complicated anomalies and new medical treatment options
  publication-title: Hematol Oncol Clin North Am.
  doi: 10.1016/j.hoc.2019.01.011
– volume: 23
  start-page: 281
  issue: 2
  year: 2019
  ident: 2022081115223122700_B91
  article-title: Shwachman-Diamond syndrome: molecular mechanisms and current perspectives
  publication-title: Mol Diagn Ther.
  doi: 10.1007/s40291-018-0368-2
– volume: 12
  start-page: 333
  issue: 4
  year: 2007
  ident: 2022081115223122700_B51
  article-title: Iron needs of babies and children
  publication-title: Paediatr Child Health.
  doi: 10.1093/pch/12.4.333
– volume: 182
  start-page: 365
  issue: 2
  year: 2020
  ident: 2022081115223122700_B96
  article-title: Broadening the phenotypic spectrum of Pearson syndrome: five new cases and a review of the literature
  publication-title: Am J Med Genet A.
  doi: 10.1002/ajmg.a.61433
– volume: 13
  start-page: 215
  issue: 4
  year: 2008
  ident: 2022081115223122700_B68
  article-title: Alpha-thalassaemia
  publication-title: Semin Fetal Neonatal Med.
  doi: 10.1016/j.siny.2008.02.006
– volume: 138(suppl 1). Abstract
  start-page: 847
  year: 2021
  ident: 2022081115223122700_B104
  article-title: Autosomal recessive congenital dyserythropoietic anemia type III is caused by mutations in the centralspindlin RACGAP1 component [abstract]
  publication-title: Blood.
  doi: 10.1182/blood-2021-150097
– volume: 35
  start-page: 237
  issue: 3
  year: 2019
  ident: 2022081115223122700_B47
  article-title: Transient erythroblastopenia of childhood: a review for the pediatric emergency medicine physician
  publication-title: Pediatr Emerg Care.
  doi: 10.1097/PEC.0000000000001760
– volume: 92
  start-page: 412
  issue: 3
  year: 1978
  ident: 2022081115223122700_B121
  article-title: Developmental changes in red blood cell counts and indices of infants after exclusion of iron deficiency by laboratory criteria and continuous iron supplementation
  publication-title: J Pediatr.
  doi: 10.1016/S0022-3476(78)80429-6
– volume: 372
  start-page: 1832
  issue: 19
  year: 2015
  ident: 2022081115223122700_B48
  article-title: Iron-deficiency anemia
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMra1401038
– volume: 215
  start-page: 152578
  issue: 10
  year: 2019
  ident: 2022081115223122700_B71
  article-title: Clinical and molecular characterization of novel deletions causing epsilon gamma delta beta thalassemia: Report of two cases
  publication-title: Pathol Res Pract.
  doi: 10.1016/j.prp.2019.152578
– volume: 8
  start-page: 2152
  issue: 10
  year: 2010
  ident: 2022081115223122700_B76
  article-title: Splenectomy and thrombosis: the case of thalassemia intermedia
  publication-title: J Thromb Haemost.
  doi: 10.1111/j.1538-7836.2010.03940.x
– volume: 12
  start-page: 2001
  issue: 7
  year: 2020
  ident: 2022081115223122700_B49
  article-title: The Role of iron in brain development: a systematic review
  publication-title: Nutrients.
  doi: 10.3390/nu12072001
– volume: 65
  start-page: e27000
  issue: 6
  year: 2018
  ident: 2022081115223122700_B81
  article-title: Children with sickle cell disease migrating to the United States from sub-Saharan Africa
  publication-title: Pediatr Blood Cancer.
  doi: 10.1002/pbc.27000
– volume: 29
  start-page: 1240
  issue: 6
  year: 2014
  ident: 2022081115223122700_B55
  article-title: Iron deficiency anemia in adolescents; a literature review
  publication-title: Nutr Hosp.
– volume: 36
  start-page: 173
  issue: 3
  year: 2014
  ident: 2022081115223122700_B30
  article-title: Acute hemolytic anemia as an initial presentation of Wilson disease in children
  publication-title: J Pediatr Hematol Oncol.
  doi: 10.1097/MPH.0000000000000127
– volume: 306
  start-page: 281
  issue: 5
  year: 1982
  ident: 2022081115223122700_B32
  article-title: Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow
  publication-title: N Engl J Med.
  doi: 10.1056/NEJM198202043060507
– volume: 138
  start-page: e20201014
  issue: 1
  year: 2016
  ident: 2022081115223122700_B59
  article-title: Prevention of childhood lead toxicity
  publication-title: Pediatrics.
– volume: 57
  start-page: 665
  issue: 5
  year: 2018
  ident: 2022081115223122700_B36
  article-title: Clinical features and treatment of primary autoimmune hemolytic anemia in childhood
  publication-title: Transfus Apheresis Sci.
  doi: 10.1016/j.transci.2018.07.014
– volume: 33
  start-page: 339
  issue: 3
  year: 2019
  ident: 2022081115223122700_B77
  article-title: Beta thalassemia: monitoring and new treatment approaches
  publication-title: Hematol Oncol Clin North Am.
  doi: 10.1016/j.hoc.2019.01.003
– volume: 121
  start-page: 4791
  issue: 23
  year: 2013
  ident: 2022081115223122700_B103
  article-title: Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23
  publication-title: Blood.
  doi: 10.1182/blood-2012-10-461392
– volume: 131
  start-page: 1406
  issue: 13
  year: 2018
  ident: 2022081115223122700_B113
  article-title: How I treat myelodysplastic syndromes of childhood
  publication-title: Blood.
  doi: 10.1182/blood-2017-09-765214
– volume: 10
  start-page: 1294
  year: 2019
  ident: 2022081115223122700_B58
  article-title: Hepcidin and anemia: a tight relationship
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2019.01294
– volume: 145
  start-page: 153
  issue: 1-2
  year: 1986
  ident: 2022081115223122700_B88
  article-title: The Aase syndrome. Case report and review of the literature
  publication-title: Eur J Pediatr.
  doi: 10.1007/BF00441882
– volume: 12
  start-page: 684569
  year: 2021
  ident: 2022081115223122700_B7
  article-title: Targeted next generation sequencing and diagnosis of congenital hemolytic anemias: a three years experience monocentric study
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2021.684569
– volume: 15
  start-page: 14
  year: 2000
  ident: 2022081115223122700_B6
  article-title: Pathophysiology of anaemia: focus on the heart and blood vessels
  publication-title: Nephrol Dial Transplant.
  doi: 10.1093/oxfordjournals.ndt.a027970
– volume: 119
  start-page: 71
  year: 2019
  ident: 2022081115223122700_B110
  article-title: Congenital disorders of bone and blood
  publication-title: Bone.
  doi: 10.1016/j.bone.2018.03.002
– volume: 376
  start-page: 1561
  issue: 16
  year: 2017
  ident: 2022081115223122700_B80
  article-title: Sickle cell disease
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMra1510865
– volume: 144
  start-page: 537
  issue: 11
  year: 2020
  ident: 2022081115223122700_B21
  article-title: Atypical hemolytic uremic syndrome: new challenges in the complement blockage era
  publication-title: Nephron.
  doi: 10.1159/000508920
– volume: 108
  start-page: 5
  issue: 1
  year: 2018
  ident: 2022081115223122700_B74
  article-title: β-Thalassemia intermedia: a comprehensive overview and novel approaches
  publication-title: Int J Hematol.
  doi: 10.1007/s12185-018-2411-9
– volume: 154
  start-page: 185
  issue: 2
  year: 2011
  ident: 2022081115223122700_B114
  article-title: Advances in the prognostication and management of advanced MDS in children
  publication-title: Br J Haematol.
  doi: 10.1111/j.1365-2141.2011.08724.x
– volume: 68
  start-page: e28949
  issue: 5
  year: 2021
  ident: 2022081115223122700_B24
  article-title: Recognizing and managing hereditary and acquired thrombotic thrombocytopenic purpura in infants and children
  publication-title: Pediatr Blood Cancer.
  doi: 10.1002/pbc.28949
– volume: 129
  start-page: 1251
  issue: 10
  year: 2017
  ident: 2022081115223122700_B69
  article-title: An international registry of survivors with Hb Bart’s hydrops fetalis syndrome
  publication-title: Blood.
  doi: 10.1182/blood-2016-08-697110
– volume: 94
  start-page: 1668
  issue: 9
  year: 2019
  ident: 2022081115223122700_B94
  article-title: Dyskeratosis congenita
  publication-title: Mayo Clin Proc.
  doi: 10.1016/j.mayocp.2019.04.032
– volume: 33
  start-page: 355
  issue: 3
  year: 2019
  ident: 2022081115223122700_B82
  article-title: Sickle cell disease: monitoring, current treatment, and therapeutics under development
  publication-title: Hematol Oncol Clin North Am.
  doi: 10.1016/j.hoc.2019.01.014
– volume: 55(suppl 2
  start-page: S47
  year: 2015
  ident: 2022081115223122700_B31
  article-title: Pathogenesis and mechanisms of antibody-mediated hemolysis
  publication-title: Transfusion.
  doi: 10.1111/trf.13147
– volume: 140
  start-page: 10
  issue: 1
  year: 2018
  ident: 2022081115223122700_B37
  article-title: A comprehensive diagnostic algorithm for direct antiglobulin test-negative autoimmune hemolytic anemia reveals the relative ratio of three mechanisms in a single laboratory
  publication-title: Acta Haematol.
  doi: 10.1159/000488753
– volume: 32
  start-page: 581
  issue: 4
  year: 2018
  ident: 2022081115223122700_B97
  article-title: The pathophysiology of acquired aplastic anemia: current concepts revisited
  publication-title: Hematol Oncol Clin North Am.
  doi: 10.1016/j.hoc.2018.03.001
– volume: 36
  start-page: 333
  issue: 2
  year: 2020
  ident: 2022081115223122700_B20
  article-title: Typical and atypical hemolytic uremic syndrome in the critically ill
  publication-title: Crit Care Clin.
  doi: 10.1016/j.ccc.2019.11.004
– volume: 96
  start-page: 655
  issue: 5
  year: 2011
  ident: 2022081115223122700_B35
  article-title: New insights into childhood autoimmune hemolytic anemia: a French national observational study of 265 children
  publication-title: Haematologica.
  doi: 10.3324/haematol.2010.036053
– volume: 21
  start-page: 57
  issue: 1
  year: 2016
  ident: 2022081115223122700_B93
  article-title: Neonatal manifestations of inherited bone marrow failure syndromes
  publication-title: Semin Fetal Neonatal Med.
  doi: 10.1016/j.siny.2015.12.003
– volume: 317
  start-page: 2297
  issue: 22
  year: 2017
  ident: 2022081115223122700_B54
  article-title: Effect of low-dose ferrous sulfate vs iron polysaccharide complex on hemoglobin concentration in young children with nutritional iron-deficiency anemia: a randomized clinical trial
  publication-title: JAMA.
  doi: 10.1001/jama.2017.6846
– volume: 8
  start-page: 1557
  issue: 1
  year: 2017
  ident: 2022081115223122700_B115
  article-title: The genomic landscape of pediatric myelodysplastic syndromes
  publication-title: Nat Commun.
  doi: 10.1038/s41467-017-01590-5
– volume: 20
  start-page: 67
  issue: 9
  year: 2018
  ident: 2022081115223122700_B98
  article-title: Updated guidelines for the treatment of acquired aplastic anemia in children
  publication-title: Curr Oncol Rep.
  doi: 10.1007/s11912-018-0716-8
– volume: 68
  start-page: e28841
  issue: 3
  year: 2021
  ident: 2022081115223122700_B111
  article-title: How we approach malignant infantile osteopetrosis
  publication-title: Pediatr Blood Cancer.
  doi: 10.1002/pbc.28841
– volume: 14
  start-page: 301
  issue: 4
  year: 2011
  ident: 2022081115223122700_B106
  article-title: Perinatal onset mevalonate kinase deficiency
  publication-title: Pediatr Dev Pathol.
  doi: 10.2350/11-02-0985-OA.1
– volume: 9
  start-page: 1075
  issue: 11
  year: 2016
  ident: 2022081115223122700_B52
  article-title: Pica as a manifestation of iron deficiency
  publication-title: Expert Rev Hematol.
  doi: 10.1080/17474086.2016.1245136
– volume: 129
  start-page: 2878
  issue: 7
  year: 2019
  ident: 2022081115223122700_B10
  article-title: Aberrant splicing contributes to severe α-spectrin-linked congenital hemolytic anemia
  publication-title: J Clin Invest.
  doi: 10.1172/JCI127195
– volume: 176
  start-page: 395
  issue: 3
  year: 2017
  ident: 2022081115223122700_B34
  article-title: The diagnosis and management of primary autoimmune haemolytic anaemia
  publication-title: Br J Haematol.
  doi: 10.1111/bjh.14478
– volume: 134
  start-page: 599
  issue: 6
  year: 2019
  ident: 2022081115223122700_B79
  article-title: Reducing health care disparities in sickle cell disease: a review
  publication-title: Public Health Rep.
  doi: 10.1177/0033354919881438
– volume: 130
  start-page: 2699
  issue: 25
  year: 2017
  ident: 2022081115223122700_B12
  article-title: Disorders of erythrocyte hydration
  publication-title: Blood.
  doi: 10.1182/blood-2017-04-590810
– volume: 103
  start-page: 285
  issue: 3
  year: 2018
  ident: 2022081115223122700_B19
  article-title: Treatment and management of children with haemolytic uraemic syndrome
  publication-title: Arch Dis Child.
  doi: 10.1136/archdischild-2016-311377
– volume: 42
  start-page: 483
  issue: 3
  year: 2015
  ident: 2022081115223122700_B3
  article-title: Reference intervals in neonatal hematology
  publication-title: Clin Perinatol.
  doi: 10.1016/j.clp.2015.04.005
– volume: 53
  start-page: 339
  issue: 2
  year: 2018
  ident: 2022081115223122700_B43
  article-title: The incidence of delayed splenic bleeding in pediatric blunt trauma
  publication-title: J Pediatr Surg.
  doi: 10.1016/j.jpedsurg.2017.10.005
– volume: 36
  start-page: 110
  issue: 2
  year: 2020
  ident: 2022081115223122700_B118
  article-title: Recent insights into trace element deficiencies: causes, recognition and correction
  publication-title: Curr Opin Gastroenterol.
  doi: 10.1097/MOG.0000000000000612
– volume: 779
  start-page: 58
  year: 2019
  ident: 2022081115223122700_B5
  article-title: Associations between single nucleotide polymorphisms and erythrocyte parameters in humans: a systematic literature review
  publication-title: Mutat Res Rev Mutat Res.
  doi: 10.1016/j.mrrev.2019.01.002
– volume: 65
  start-page: 579
  issue: 3
  year: 2018
  ident: 2022081115223122700_B15
  article-title: Red blood cell enzyme disorders
  publication-title: Pediatr Clin North Am.
  doi: 10.1016/j.pcl.2018.02.005
– volume: 98
  start-page: 1788
  issue: 11
  year: 2013
  ident: 2022081115223122700_B102
  article-title: Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis
  publication-title: Haematologica.
  doi: 10.3324/haematol.2013.085522
– volume: 24
  start-page: 266
  issue: 3
  year: 2000
  ident: 2022081115223122700_B105
  article-title: Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
  publication-title: Nat Genet.
  doi: 10.1038/73480
– volume: 17
  start-page: 277
  issue: 2
  year: 2003
  ident: 2022081115223122700_B112
  article-title: A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases
  publication-title: Leukemia.
  doi: 10.1038/sj.leu.2402765
– volume: 37
  start-page: 100589
  year: 2019
  ident: 2022081115223122700_B89
  article-title: Genotype-phenotype associations in Fanconi anemia: A literature review
  publication-title: Blood Rev.
  doi: 10.1016/j.blre.2019.100589
– volume: 2016
  start-page: 690
  issue: 1
  year: 2016
  ident: 2022081115223122700_B40
  article-title: Warm antibody autoimmune hemolytic anemia
  publication-title: Hematology (Am Soc Hematol Educ Program).
  doi: 10.1182/asheducation-2016.1.690
– volume: 19
  start-page: 609
  issue: 6
  year: 2017
  ident: 2022081115223122700_B65
  article-title: β-Thalassemia
  publication-title: Genet Med.
  doi: 10.1038/gim.2016.173
– volume: 12
  start-page: 1037
  issue: 12
  year: 2019
  ident: 2022081115223122700_B95
  article-title: An update on the biology and management of dyskeratosis congenita and related telomere biology disorders
  publication-title: Expert Rev Hematol.
  doi: 10.1080/17474086.2019.1662720
– volume: 93
  start-page: 672
  issue: 5
  year: 2018
  ident: 2022081115223122700_B8
  article-title: Multi-gene panel testing improves diagnosis and management of patients with hereditary anemias
  publication-title: Am J Hematol.
  doi: 10.1002/ajh.25058
– volume: 380
  start-page: 335
  issue: 4
  year: 2019
  ident: 2022081115223122700_B25
  article-title: Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMoa1806311
– volume: 105
  start-page: 260
  issue: 2
  year: 2020
  ident: 2022081115223122700_B57
  article-title: Iron metabolism and iron disorders revisited in the hepcidin era
  publication-title: Haematologica.
  doi: 10.3324/haematol.2019.232124
– volume: 34
  start-page: 504
  issue: 4
  year: 2019
  ident: 2022081115223122700_B117
  article-title: Copper deficiency: causes, manifestations, and treatment
  publication-title: Nutr Clin Pract.
  doi: 10.1002/ncp.10328
SSID ssj0014325
Score 2.5962222
SecondaryResourceType review_article
Snippet The World Health Organization estimates that approximately a quarter of the world's population suffers from anemia, including almost half of preschool-age...
The World Health Organization estimates that approximately a quarter of the world’s population suffers from anemia, including almost half of preschool-age...
Commissioned and introduced by Associate Editors Irene Roberts and Thomas Ortel, this Review Series focuses on common areas in pediatric hematology practice,...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 571
SubjectTerms Anemia - diagnosis
Anemia - etiology
Anemia - therapy
Anemia, Iron-Deficiency - drug therapy
Child
Child, Preschool
Genetic Testing
Humans
Nervous System Diseases
Pediatric Hematology
Title Anemia in the pediatric patient
URI https://dx.doi.org/10.1182/blood.2020006479
https://www.ncbi.nlm.nih.gov/pubmed/35213686
https://www.proquest.com/docview/2633856058
https://pubmed.ncbi.nlm.nih.gov/PMC9373018
Volume 140
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9QwEB5BEcdLBVuOpRxBQkgIbbvxFedxqYAKVCREK_UtchybrtpmK0gf4NczPpJstlBBX6IosRPLXzKe8cx8A_CymjLFaV6h5sbRQCEM5aCkZqJzK3ROsryqXDby3mexe8A-HvLDPq3dZ5c05Zb-9ce8kqugitcQV5cl-x_Idg_FC3iO-OIREcbjP2E8q83pXLWhimdt1Y2WLHXgsD2JVeF9sI3bPf8W0Qok_cdvPmwt7wCg8egYWfsdgC41ZRA56dYhVz4uHYi6QI0UMV0WXDw2DGsgD1ULL4pX6ehafUg9mtY-y4eFWjArpNVf_S18OyHetymuww2CiryTRJ--9H4eRkmoMREH2zqSJdlefcvfFIeLhsFqfOuSwrB_F9ajpp_MAmz34JqpR7Axq1WzOP2ZvEp87K13aozg5tv27PZOW4FvBLf2YuDDBjwPUCfzOkGokw7qJEJ9Hw7ev9vf2Z3E2hYTzVjWTBQ32lhCSltaimah4AoFoHK1whi3joRP4q8ipsSmqGDy1IoqN7JikmtaKqrpA1irF7V5BAmxkmgmlE21YlOjcop9UYvLrNU6tdkYttuJK3Qkfnf1R04KbwBKUvipLvqpHsPrrsdZID25pC1tsSii0haUsQI_mkt6vWhhK3BSnZNK1WZx_qMgglLJnbN-DA8DjN0Y0FhIqZBiDNkA4K6B40of3qnnR54zHacDlzL5-Eqj3YQ7_X_3BNaa7-fmKeqiTfnMf86_AdkghVI
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Anemia+in+the+pediatric+patient&rft.jtitle=Blood&rft.au=Gallagher%2C+Patrick+G.&rft.date=2022-08-11&rft.pub=Elsevier+Inc&rft.issn=0006-4971&rft.volume=140&rft.issue=6&rft.spage=571&rft.epage=593&rft_id=info:doi/10.1182%2Fblood.2020006479&rft.externalDocID=S0006497122002786
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-4971&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-4971&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-4971&client=summon