The early improvement of depressive symptoms as a potential predictor of response to antidepressants in depressive patients who failed to respond to previous antidepressant treatments. Analysis of naturalistic data

• Published in: European psychiatry Vol. 27; no. 7; pp. 522 - 527
• Main Authors: Bares, M, Novak, T, Kopecek, M, Stopkova, P, Kozeny, J, Höschl, C
• Format: Journal Article
• Language: English
• Published: Paris Elsevier SAS 01.10.2012; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Antidepressants; Antidepressive Agents - therapeutic use; Biological and medical sciences; Depression; Depression - diagnosis; Depression - drug therapy; Depressive Disorder - diagnosis; Depressive Disorder - drug therapy; Early improvement; Female; Humans; Internal Medicine; Male; Medical sciences; Middle Aged; Mood disorders; Neuropharmacology; Pharmacology. Drug treatments; Predictive Value of Tests; Psychiatric Status Rating Scales; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Resistant depression; Response prediction; Treatment; Treatment Outcome; Early improvement; Resistant depression; Treatment; Antidepressants; Response prediction; Mood disorder; Human; Data analysis; Psychotropic; Prediction; Depression; Symptomatology; Antidepressant agent; Early; Predictive factor

Abstract Introduction Current studies suggest that improvement of depressive symptoms after 2 weeks of treatment could predict the subsequent response. The aim of our study was to compare the predictive effect of early improvement (EI) after 1 and 2 weeks of treatment in patients who had failed to r...