Association about dietary vitamin C intake on the risk of ovarian cancer: a meta-analysis

• Published in: Bioscience reports Vol. 40; no. 8
• Main Authors: Long, Yuhang, Fei, Hui, Xu, Sumei, Wen, Jianzhen, Ye, Lihua, Su, Zhaojuan
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 28.08.2020
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Ascorbic Acid - administration & dosage; Ascorbic Acid - adverse effects; Cancer; Diet - adverse effects; Female; Humans; Middle Aged; Observational Studies as Topic; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - epidemiology; Risk Assessment; Risk Factors; Young Adult; Dietary; Vitamin C; Meta-analysis; Ovarian cancer
• DOI: 10.1042/BSR20192385
• ISSN: 0144-8463; 1573-4935

Changes in dietary vitamin C intake have been related to the risks of various cancers. However, the association between dietary vitamin C intake and the risk of ovarian cancer has not been fully determined. A meta-analysis was performed to evaluate the relationship between vitamin C intake and ovarian cancer risk. Observational studies that evaluated the association between vitamin C intake and ovarian cancer risk were identified via systematic search of PubMed and Embase databases. A random-effect model was used to combine relative risk (RR) with corresponding 95% confidence intervals (CIs). As a result, 16 studies (5 cohort studies and 11 case–control studies) with 4553 cases and 439,741 participants were included. Pooled results showed that dietary vitamin C intake had non-significant association on the risk of ovarian cancer (RR = 0.95, 95%CI = 0.81–1.11, I2 = 52.1%, Pfor heterogeneity = 0.008). Subgroup analyses according to characteristics including geographic location and study design showed consistent results with the overall result. In summary, findings from the present study indicated that dietary vitamin C intake is not associated with the risk of ovarian cancer.