Gender-Related Differences on Polyamine Metabolome in Liquid Biopsies by a Simple and Sensitive Two-Step Liquid-Liquid Extraction and LC-MS/MS

• Published in: Biomolecules (Basel, Switzerland) Vol. 9; no. 12; p. 779
• Main Authors: Samarra, Iris, Ramos-Molina, Bruno, Queipo-Ortuño, M Isabel, Tinahones, Francisco J, Arola, Lluís, Delpino-Rius, Antoni, Herrero, Pol, Canela, Núria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 26.11.2019
• Subjects: acetylpolyamines; polyamine metabolism; LC-MS/MS; liquid biopsies; polyamines; obesity

Polyamines are involved in the regulation of many cellular functions and are promising biomarkers of numerous physiological conditions. Since the concentrations of these compounds in biological fluids are low, sample extraction is one of the most critical steps of their analysis. Here, we developed...