Evidence of an increased risk of hearing loss in heterozygous carriers in a Wolfram syndrome family

• Published in: Human genetics Vol. 103; no. 4; pp. 470 - 474
• Main Authors: OHATA, T, KOIZUMI, A, TAKADA, G, KAYO, T, SHOJI, Y, WATANABE, A, MONOH, K, HIGASHI, K, ITO, S, OGAWA, O, WADA, Y
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.10.1998; Berlin; New York, NY
• Subjects: Adolescent; Adult; Biological and medical sciences; Child; Chromosomes, Human, Pair 4; Complex syndromes; Female; Genetic Markers; Haplotypes; Hearing Loss, Sensorineural - etiology; Heterozygote; Humans; Lod Score; Male; Medical genetics; Medical sciences; Pedigree; Risk; Wolfram Syndrome - genetics; Endocrinopathy; Genetic mapping; Human; Linkage; Auditory disorder; Chromosome B4; Genetic disease; Hearing loss; Eye disease; Association; Wolfram syndrome; Genetics; Complex syndrome

Wolfram syndrome (MIM 222300) is characterized by juvenile-onset diabetes mellitus and optic atrophy. Previous linkage analyses in the United States and UK families have indicated that the gene for Wolfram syndrome (WFS) is localized on the short arm of chromosome 4. We herein confirm the linkage of...