The CSRP2BP histone acetyltransferase drives smooth muscle gene expression

• Published in: Nucleic acids research Vol. 45; no. 6; pp. 3046 - 3058
• Main Authors: Ma, Yanlin, Li, Qi, Li, Ankang, Wei, Yunjian, Long, Ping, Jiang, Xinxing, Sun, Fei, Weiskirchen, Ralf, Wu, Bangyong, Liang, Chao, Grötzinger, Joachim, Wei, Yanxing, Yu, Wei, Mercola, Mark, Huang, Yuanhua, Wang, Jun, Yu, Yanhong, Schwartz, Robert J.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 07.04.2017
• Subjects: Acetylation; Animals; Cell Line; Cell Nucleus - enzymology; Cells, Cultured; Chromatin - enzymology; Gene Expression; Gene Expression Regulation; Gene regulation, Chromatin and Epigenetics; Histone Acetyltransferases - metabolism; Histones - metabolism; Humans; Mice; Myocytes, Smooth Muscle - enzymology; Myocytes, Smooth Muscle - metabolism; Nuclear Proteins - metabolism; Promoter Regions, Genetic; Rats; Trans-Activators - metabolism; Transcription Factors - metabolism

The expression of nearly all smooth muscle genes are controlled by serum response factor binding sites in their promoter regions. However, SRF alone is not sufficient for regulating smooth muscle cell development. It associates with other cardiovascular specific cofactors to regulate smooth muscle g...