A New Proposal for the Target Value for Home BP in Type 2 Diabetes Patients: The J-HOP Study
OBJECTIVE The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) st...
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Published in | American journal of hypertension Vol. 28; no. 8; pp. 971 - 979 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Oxford University Press
01.08.2015
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Abstract | OBJECTIVE
The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM.
METHODS
This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,310 patients who had at least 1 cardiovascular risk factor, and clinic and home BP monitoring was performed. The urinary albumin-to-creatinine ratio (UACR) was measured as a marker of microvascular disease. Quadratic equations of the relationship between clinic/home systolic BP (SBP) and log-transformed UACR were used to determine the home BP value. Home BP levels corresponding to clinic SBP/diastolic BP (DBP) level using the UACR values were calculated separately by the presence/absence of diabetes.
RESULTS
The mean age of the patients was 64.9±10.9 years; 47.0% were males. Of the 4,310 subjects enrolled, 1,057 (24.5%) had T2DM (the DM group) and 3,253 (75.5%) did not (non-DM group). The home BP levels equivalent to clinic BP 140/90mm Hg were 135/84 and 135/83mm Hg in the DM and non-DM groups, respectively. The home SBP levels equivalent to clinic SBP 130/80mm Hg were 122/79mm Hg in the non-DM group and 129/78mm Hg in the DM group.
CONCLUSIONS
Regardless of diabetic status, the home BP level that corresponds to the clinic SBP 140/90mm Hg was 135/85mm Hg. In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80mm Hg was 129/78mm Hg with regard to the extent of microvascular disease. |
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AbstractList | OBJECTIVEThe target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM.METHODSThis is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,310 patients who had at least 1 cardiovascular risk factor, and clinic and home BP monitoring was performed. The urinary albumin-to-creatinine ratio (UACR) was measured as a marker of microvascular disease. Quadratic equations of the relationship between clinic/home systolic BP (SBP) and log-transformed UACR were used to determine the home BP value. Home BP levels corresponding to clinic SBP/diastolic BP (DBP) level using the UACR values were calculated separately by the presence/absence of diabetes.RESULTSThe mean age of the patients was 64.9±10.9 years; 47.0% were males. Of the 4,310 subjects enrolled, 1,057 (24.5%) had T2DM (the DM group) and 3,253 (75.5%) did not (non-DM group). The home BP levels equivalent to clinic BP 140/90 mm Hg were 135/84 and 135/83 mm Hg in the DM and non-DM groups, respectively. The home SBP levels equivalent to clinic SBP 130/80 mm Hg were 122/79 mm Hg in the non-DM group and 129/78 mm Hg in the DM group.CONCLUSIONSRegardless of diabetic status, the home BP level that corresponds to the clinic SBP 140/90 mm Hg was 135/85 mm Hg. In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80 mm Hg was 129/78 mm Hg with regard to the extent of microvascular disease. OBJECTIVE The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,310 patients who had at least 1 cardiovascular risk factor, and clinic and home BP monitoring was performed. The urinary albumin-to-creatinine ratio (UACR) was measured as a marker of microvascular disease. Quadratic equations of the relationship between clinic/home systolic BP (SBP) and log-transformed UACR were used to determine the home BP value. Home BP levels corresponding to clinic SBP/diastolic BP (DBP) level using the UACR values were calculated separately by the presence/absence of diabetes. RESULTS The mean age of the patients was 64.9±10.9 years; 47.0% were males. Of the 4,310 subjects enrolled, 1,057 (24.5%) had T2DM (the DM group) and 3,253 (75.5%) did not (non-DM group). The home BP levels equivalent to clinic BP 140/90mm Hg were 135/84 and 135/83mm Hg in the DM and non-DM groups, respectively. The home SBP levels equivalent to clinic SBP 130/80mm Hg were 122/79mm Hg in the non-DM group and 129/78mm Hg in the DM group. CONCLUSIONS Regardless of diabetic status, the home BP level that corresponds to the clinic SBP 140/90mm Hg was 135/85mm Hg. In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80mm Hg was 129/78mm Hg with regard to the extent of microvascular disease. The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,310 patients who had at least 1 cardiovascular risk factor, and clinic and home BP monitoring was performed. The urinary albumin-to-creatinine ratio (UACR) was measured as a marker of microvascular disease. Quadratic equations of the relationship between clinic/home systolic BP (SBP) and log-transformed UACR were used to determine the home BP value. Home BP levels corresponding to clinic SBP/diastolic BP (DBP) level using the UACR values were calculated separately by the presence/absence of diabetes. The mean age of the patients was 64.9±10.9 years; 47.0% were males. Of the 4,310 subjects enrolled, 1,057 (24.5%) had T2DM (the DM group) and 3,253 (75.5%) did not (non-DM group). The home BP levels equivalent to clinic BP 140/90 mm Hg were 135/84 and 135/83 mm Hg in the DM and non-DM groups, respectively. The home SBP levels equivalent to clinic SBP 130/80 mm Hg were 122/79 mm Hg in the non-DM group and 129/78 mm Hg in the DM group. Regardless of diabetic status, the home BP level that corresponds to the clinic SBP 140/90 mm Hg was 135/85 mm Hg. In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80 mm Hg was 129/78 mm Hg with regard to the extent of microvascular disease. OBJECTIVE The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,310 patients who had at least 1 cardiovascular risk factor, and clinic and home BP monitoring was performed. The urinary albumin-to-creatinine ratio (UACR) was measured as a marker of microvascular disease. Quadratic equations of the relationship between clinic/home systolic BP (SBP) and log-transformed UACR were used to determine the home BP value. Home BP levels corresponding to clinic SBP/diastolic BP (DBP) level using the UACR values were calculated separately by the presence/absence of diabetes. RESULTS The mean age of the patients was 64.9±10.9 years; 47.0% were males. Of the 4,310 subjects enrolled, 1,057 (24.5%) had T2DM (the DM group) and 3,253 (75.5%) did not (non-DM group). The home BP levels equivalent to clinic BP 140/90mm Hg were 135/84 and 135/83mm Hg in the DM and non-DM groups, respectively. The home SBP levels equivalent to clinic SBP 130/80mm Hg were 122/79mm Hg in the non-DM group and 129/78mm Hg in the DM group. CONCLUSIONS Regardless of diabetic status, the home BP level that corresponds to the clinic SBP 140/90mm Hg was 135/85mm Hg. In patients with T2DM, the home SBP level equivalent to clinic SBP 130/80mm Hg was 129/78mm Hg with regard to the extent of microvascular disease. |
Author | Eguchi, Kazuo Komori, Takahiro Nagasaka, Shoichiro Kario, Kazuomi Hoshide, Satoshi |
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Cites_doi | 10.1161/01.CIR.0000154900.76284.F6 10.1097/MBP.0b013e328346d669 10.1111/j.1559-4564.2007.06124.x 10.1136/bmj.317.7160.703 10.1093/eurheartj/eht151 10.1093/ajh/hpt054 10.1038/hr.2009.34 10.1001/jama.2013.284427 10.1038/ajh.2010.15 10.1056/NEJMoa1001286 10.1093/ajh/hpt089 10.1161/HYPERTENSIONAHA.110.162446 10.1161/01.CIR.0000160923.04524.5B 10.1016/0140-6736(92)91401-S 10.2337/db06-1646 10.1038/hr.2013.38 10.1111/j.1524-6175.2006.04739.x 10.1093/eurheartj/ehm236 10.2337/diacare.25.12.2218 10.1093/ajh/hpt290 10.5551/jat.15792 10.1001/jama.286.4.421 10.1161/01.HYP.30.1.1 10.1097/HJH.0b013e328361732c 10.1038/ajh.2010.17 10.2337/dc14-S014 10.1161/HYPERTENSIONAHA.111.171645 10.1161/HYPERTENSIONAHA.107.189011 10.1111/j.2040-1124.2010.00074.x 10.5664/jcsm.27497 10.1001/archinte.158.5.481 10.1001/jama.291.11.1342 10.1097/HJH.0b013e3283531eaf 10.1007/s00125-006-0297-1 10.1161/01.CIR.0000031732.78052.81 10.1016/S0895-7061(96)00407-4 |
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Keywords | blood pressure urinary microalbumin type 2 diabetes hypertension home BP |
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The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to... The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine... OBJECTIVE The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to... OBJECTIVEThe target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to... |
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SubjectTerms | Aged Albuminuria - urine Blood Pressure Blood Pressure Determination Blood Pressure Monitoring, Ambulatory Case-Control Studies Creatinine - urine Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - etiology Diabetic Angiopathies - physiopathology Diabetic Angiopathies - urine Female Humans Hypertension - complications Hypertension - physiopathology Linear Models Male Middle Aged |
Title | A New Proposal for the Target Value for Home BP in Type 2 Diabetes Patients: The J-HOP Study |
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