Presidential Address: Imagination trumps knowledge
Abstract Multiple organ failure (MOF) emerged 30 years ago and became our research focus. Over the years, we have proposed a series of cartoons that rallied multidisciplinary translational research teams around common themes to generate “win-win” hypotheses that when tested (right or wrong) have adv...
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| Published in | The American journal of surgery Vol. 200; no. 6; pp. 671 - 677 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.12.2010
Elsevier Limited |
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| Abstract | Abstract Multiple organ failure (MOF) emerged 30 years ago and became our research focus. Over the years, we have proposed a series of cartoons that rallied multidisciplinary translational research teams around common themes to generate “win-win” hypotheses that when tested (right or wrong) have advanced our understanding of MOF. MOF has a bimodal trajectory, and the gut plays a role in both trajectories. Early MOF occurs because of excessive proinflammation (ie, systemic inflammatory response syndrome [SIRS]), and early gut ischemia-reperfusion can amplify SIRS and contribute to the early fulminant SIRS-MOF trajectory. Fortunately, most patients survive early SIRS, but some develop excessive anti-inflammation (ie, compensatory anti-inflammatory response syndrome). The gut also plays a role in this late indolent compensatory anti-inflammatory response syndrome–MOF trajectory. Multiple factors cause progressive gut dysfunction such that the gut (an important immunologic organ) worsens compensatory anti-inflammatory response syndrome and becomes the reservoir for pathogens and toxins that cause late sepsis. |
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| AbstractList | Multiple organ failure (MOF) emerged 30 years ago and became our research focus. Over the years, we have proposed a series of cartoons that rallied multidisciplinary translational research teams around common themes to generate "win-win" hypotheses that when tested (right or wrong) have advanced our understanding of MOF. MOF has a bimodal trajectory, and the gut plays a role in both trajectories. Early MOF occurs because of excessive proinflammation (ie, systemic inflammatory response syndrome [SIRS]), and early gut ischemia-reperfusion can amplify SIRS and contribute to the early fulminant SIRS-MOF trajectory. Fortunately, most patients survive early SIRS, but some develop excessive anti-inflammation (ie, compensatory anti-inflammatory response syndrome). The gut also plays a role in this late indolent compensatory anti-inflammatory response syndrome-MOF trajectory. Multiple factors cause progressive gut dysfunction such that the gut (an important immunologic organ) worsens compensatory anti-inflammatory response syndrome and becomes the reservoir for pathogens and toxins that cause late sepsis. Abstract Multiple organ failure (MOF) emerged 30 years ago and became our research focus. Over the years, we have proposed a series of cartoons that rallied multidisciplinary translational research teams around common themes to generate “win-win” hypotheses that when tested (right or wrong) have advanced our understanding of MOF. MOF has a bimodal trajectory, and the gut plays a role in both trajectories. Early MOF occurs because of excessive proinflammation (ie, systemic inflammatory response syndrome [SIRS]), and early gut ischemia-reperfusion can amplify SIRS and contribute to the early fulminant SIRS-MOF trajectory. Fortunately, most patients survive early SIRS, but some develop excessive anti-inflammation (ie, compensatory anti-inflammatory response syndrome). The gut also plays a role in this late indolent compensatory anti-inflammatory response syndrome–MOF trajectory. Multiple factors cause progressive gut dysfunction such that the gut (an important immunologic organ) worsens compensatory anti-inflammatory response syndrome and becomes the reservoir for pathogens and toxins that cause late sepsis. |
| Author | Moore, Frederick A., M.D |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21146000$$D View this record in MEDLINE/PubMed |
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| Keywords | Multiple organ failure Systemic inflammatory response Compensatory anti-inflammatory response Enteral nutrition Gut ischemia-reperfusion |
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| References | Moore, Weisbrodt (bib23) 2003; 8 Sato, Moore, Kone (bib37) 2006; 290 Maier, Lefering, Lehnert (bib32) 2007; 28 Moore, Moore, Jones (bib3) 1989; 29 Peterson, Moore, Jones (bib10) 1988; 104 Moore, Jones (bib2) 1986; 26 Moore, Moore, Kudsk (bib4) 1994; 37 Moore, Peterson, Moore (bib19) 1990; 108 Botha, Moore, Moore (bib15) 1995; 39 Botha, Moore, Moore (bib17) 1996; 83 Ciesla, Moore, Johnson, Burch, Cothren, Sauaia (bib26) 2005; 140 McQuiggan, Kozar, Sailors (bib38) 2008; 32 Moore (bib21) 1999; 178 Kudsk, Minard, Croce (bib7) 1996; 224 Kozar, Weisbrodt, Moore (bib24) 2008 Kozar, McQuiggan, Moore (bib39) 2002; 104 Kang, Kudsk (bib25) 2007; 31 Gogos, Drosou, Bassaris, Skoutelis (bib35) 2000; 181 Van Dissel, van Langevelde, Westendorp (bib34) 1998; 351 Anderson, Moore, Moore (bib1) 1992; 7 Border, Hassett, LaDuca (bib8) 1987; 206 Hassoun, Kone, Mercer (bib22) 2001; 15 Suliburk, Helmer, Moore, Mercer (bib28) 2008; 40 Rivers, Kruse, Jacobsen (bib36) 2007; 35 Deitch, Winterton, Li, Berg (bib9) 1987; 205 Moore, Feliciano, Andrassy (bib5) 1992; 216 Partrick, Moore, Moore (bib16) 1996; 172 Moore, Moore, Franciose (bib11) 1994; 37 Kudsk, Croce, Fabian (bib6) 1992; 215 Moore, Moore, Poggetti (bib12) 1991; 31 Moore, Sauaia, Moore (bib18) 1996; 40 Moore, Moore (bib13) 1995; 75 Mannick (bib29) 2002; 3 Osuchowski, Welch, Yang (bib31) 2007; 179 Xiao, Siddiqui, Remick (bib33) 2006; 74 Botha, Moore, Moore (bib14) 1995; 118 Bone (bib20) 1996; 125 Osuchowski, Welch, Siddiqui, Remick (bib30) 2006; 177 Dombrovskiy, Martin, Sunderram, Paz (bib27) 2007; 35 Gogos (10.1016/j.amjsurg.2010.05.009_bib35) 2000; 181 Kozar (10.1016/j.amjsurg.2010.05.009_bib24) 2008 Moore (10.1016/j.amjsurg.2010.05.009_bib2) 1986; 26 Partrick (10.1016/j.amjsurg.2010.05.009_bib16) 1996; 172 Moore (10.1016/j.amjsurg.2010.05.009_bib12) 1991; 31 Moore (10.1016/j.amjsurg.2010.05.009_bib21) 1999; 178 Botha (10.1016/j.amjsurg.2010.05.009_bib14) 1995; 118 Moore (10.1016/j.amjsurg.2010.05.009_bib11) 1994; 37 Botha (10.1016/j.amjsurg.2010.05.009_bib15) 1995; 39 Moore (10.1016/j.amjsurg.2010.05.009_bib3) 1989; 29 Mannick (10.1016/j.amjsurg.2010.05.009_bib29) 2002; 3 Kozar (10.1016/j.amjsurg.2010.05.009_bib39) 2002; 104 Deitch (10.1016/j.amjsurg.2010.05.009_bib9) 1987; 205 Rivers (10.1016/j.amjsurg.2010.05.009_bib36) 2007; 35 Kudsk (10.1016/j.amjsurg.2010.05.009_bib6) 1992; 215 Dombrovskiy (10.1016/j.amjsurg.2010.05.009_bib27) 2007; 35 Ciesla (10.1016/j.amjsurg.2010.05.009_bib26) 2005; 140 Moore (10.1016/j.amjsurg.2010.05.009_bib19) 1990; 108 Bone (10.1016/j.amjsurg.2010.05.009_bib20) 1996; 125 Moore (10.1016/j.amjsurg.2010.05.009_bib5) 1992; 216 Osuchowski (10.1016/j.amjsurg.2010.05.009_bib31) 2007; 179 Van Dissel (10.1016/j.amjsurg.2010.05.009_bib34) 1998; 351 Anderson (10.1016/j.amjsurg.2010.05.009_bib1) 1992; 7 Moore (10.1016/j.amjsurg.2010.05.009_bib23) 2003; 8 Moore (10.1016/j.amjsurg.2010.05.009_bib4) 1994; 37 Suliburk (10.1016/j.amjsurg.2010.05.009_bib28) 2008; 40 McQuiggan (10.1016/j.amjsurg.2010.05.009_bib38) 2008; 32 Kudsk (10.1016/j.amjsurg.2010.05.009_bib7) 1996; 224 Kang (10.1016/j.amjsurg.2010.05.009_bib25) 2007; 31 Maier (10.1016/j.amjsurg.2010.05.009_bib32) 2007; 28 Xiao (10.1016/j.amjsurg.2010.05.009_bib33) 2006; 74 Moore (10.1016/j.amjsurg.2010.05.009_bib13) 1995; 75 Border (10.1016/j.amjsurg.2010.05.009_bib8) 1987; 206 Moore (10.1016/j.amjsurg.2010.05.009_bib18) 1996; 40 Hassoun (10.1016/j.amjsurg.2010.05.009_bib22) 2001; 15 Peterson (10.1016/j.amjsurg.2010.05.009_bib10) 1988; 104 Sato (10.1016/j.amjsurg.2010.05.009_bib37) 2006; 290 Botha (10.1016/j.amjsurg.2010.05.009_bib17) 1996; 83 Osuchowski (10.1016/j.amjsurg.2010.05.009_bib30) 2006; 177 |
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| Snippet | Abstract Multiple organ failure (MOF) emerged 30 years ago and became our research focus. Over the years, we have proposed a series of cartoons that rallied... Multiple organ failure (MOF) emerged 30 years ago and became our research focus. Over the years, we have proposed a series of cartoons that rallied... |
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| SubjectTerms | Animals Compensatory anti-inflammatory response Enteral Nutrition Gastrointestinal Tract - physiopathology Gut ischemia-reperfusion Humans Inflammation Inflammatory response Ischemia Mental task performance Mortality Multiple organ dysfunction syndrome Multiple organ failure Multiple Organ Failure - etiology Multiple Organ Failure - physiopathology Multiple Organ Failure - prevention & control Nosocomial infections Protein-Energy Malnutrition - complications Protein-Energy Malnutrition - physiopathology Reperfusion Rodents Sepsis Surgery Systemic inflammatory response Systemic inflammatory response syndrome Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - physiopathology Toxins Trajectories Translational Medical Research |
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| Title | Presidential Address: Imagination trumps knowledge |
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