A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects

• Published in: Analytica chimica acta Vol. 1037; pp. 327 - 337
• Main Authors: Gallart-Ayala, Héctor, Konz, Ioana, Mehl, Florence, Teav, Tony, Oikonomidi, Aikaterini, Peyratout, Gwendoline, van der Velpen, Vera, Popp, Julius, Ivanisevic, Julijana
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 11.12.2018; Elsevier BV
• Subjects: Aged; Amino acids; Annotations; Body fluids; Brain; Central nervous system; Cerebrospinal fluid; Cerebrospinal Fluid - metabolism; Chromatography, Liquid; Cognitive ability; Cognitive Dysfunction - metabolism; Cohort Studies; Cohort study; CSF; Female; Gender differences; Geriatrics; Glycolysis; Healthy Volunteers; HILIC; Homeostasis; Humans; Liquid chromatography; Male; Mass Spectrometry; Mass spectroscopy; Metabolism; Metabolite identification; Metabolites; Metabolome; Metabolomics; Middle Aged; Neurological diseases; Older people; pH effects; Rangefinding; Sex Characteristics; Taurine; Tricarboxylic acid cycle; Metabolomics; Gender differences; Metabolite identification; HILIC; Cohort study; CSF

Cerebrospinal fluid (CSF) is a key body fluid that maintains the homeostasis in central nervous system (CNS). As a biofluid whose content reflects the brain metabolic activity, the CSF has been profiled in the context of neurological diseases to provide novel insights into the disease mechanisms. Ho...