Highly Sensitive and Linear Resonator-Based Biosensor for White Blood Cell Counting: Feasible Measurement Method and Intrinsic Mechanism Exploration

• Published in: Biosensors (Basel) Vol. 14; no. 4; p. 180
• Main Authors: Wang, Yi-Ke, Shi, Bo-Wen, Zhao, Jun-Ming, Wang, Yan-Xiong, Jiang, Yan-Feng, Yang, Gang-Long, Gao, Xiao-Dong, Qiang, Tian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Automation; Bacterial infections; Biological properties; Biological samples; Biosensing Techniques; Biosensors; Blood; Blood cell count; Blood tests; Cardiovascular disease; Cells; Diabetes; Dielectric constant; Dielectric properties; Disease prevention; Electrical properties; Electromagnetic fields; Evaluation; Evaporation; Fabrication; Frequency shift; Hematology; highly sensitive; Humans; Inductors; Infections; Laboratories; Leukocyte Count; Leukocytes; Leukocytes - cytology; linear response; Mathematical models; Measurement methods; Medical examination; microwave biosensor; Microwave sensors; Microwaves; Osmosis; Osmotic pressure; Permittivity; permittivity-inspired; Resonators; Sensors; Substrates; WBC counting; China; linear response; highly sensitive; microwave biosensor; permittivity-inspired; WBC counting

Since different quantities of white blood cells (WBCs) in solution possess an adaptive osmotic pressure of cells, the WBCs themselves and in solution have similar concentrations, resulting in them having similar dielectric properties. Therefore, a microwave sensor could have difficulty in sensing th...