Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions

• Published in: Human molecular genetics Vol. 13; no. 6; pp. 609 - 616
• Main Authors: Li, Jun Z., Vawter, Marquis P., Walsh, David M., Tomita, Hiroaki, Evans, Simon J., Choudary, Prabhakara V., Lopez, Juan F., Avelar, Abigail, Shokoohi, Vida, Chung, Tisha, Mesarwi, Omar, Jones, Edward G., Watson, Stanley J., Akil, Huda, Bunney, William E., Myers, Richard M.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.03.2004; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Biological and medical sciences; Brain - metabolism; Classical genetics, quantitative genetics, hybrids; Cysteine Endopeptidases - metabolism; Energy Metabolism - genetics; Female; Fundamental and applied biological sciences. Psychology; Gene Expression; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Molecular and cellular biology; Mood Disorders - metabolism; Multienzyme Complexes - metabolism; Oligonucleotide Array Sequence Analysis; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; Human; pH; Tissue; Genetics; Gene expression; Postmortem

Studies of gene expression abnormalities in psychiatric or neurological disorders often involve the use of postmortem brain tissue. Compared with single-cell organisms or clonal cell lines, the biological environment and medical history of human subjects cannot be controlled, and are often difficult...