Prefrontal Cortical GABAergic Dysfunction Contributes to Age-Related Working Memory Impairment

• Published in: The Journal of neuroscience Vol. 34; no. 10; pp. 3457 - 3466
• Main Authors: Bañuelos, Cristina, Beas, B. Sofia, McQuail, Joseph A., Gilbert, Ryan J., Frazier, Charles J., Setlow, Barry, Bizon, Jennifer L.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 05.03.2014
• Subjects: Aging - drug effects; Aging - physiology; Animals; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists - pharmacology; Male; Memory Disorders - metabolism; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Rats; Rats, Inbred F344; Reaction Time - drug effects; Reaction Time - physiology; Receptors, GABA-B - metabolism; Receptors, GABA-B - physiology; inhibition; GABA(B) receptor; aging; CGP55845; prefrontal cortex; executive function

Working memory functions supported by the prefrontal cortex decline in normal aging. Disruption of corticolimbic GABAergic inhibitory circuits can impair working memory in young subjects; however, relatively little is known regarding how aging impacts prefrontal cortical GABAergic signaling and whet...