Comprehensive translational profiling and STE AI uncover rapid control of protein biosynthesis during cell stress

• Published in: Nucleic acids research Vol. 52; no. 13; pp. 7925 - 7946
• Main Authors: Horvath, Attila, Janapala, Yoshika, Woodward, Katrina, Mahmud, Shafi, Cleynen, Alice, Gardiner, Elizabeth E, Hannan, Ross D, Eyras, Eduardo, Preiss, Thomas, Shirokikh, Nikolay E
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.07.2024
• Subjects: Biochemistry, Molecular Biology; Genomics; Life Sciences; Quantitative Methods; RNA and RNA-protein complexes

Translational control is important in all life, but it remains a challenge to accurately quantify. When ribosomes translate messenger (m)RNA into proteins, they attach to the mRNA in series, forming poly(ribo)somes, and can co-localize. Here, we computationally model new types of co-localized riboso...