Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals

• Published in: The Journal of neuroscience Vol. 37; no. 16; pp. 4323 - 4331
• Main Authors: Schultz, Aaron P., Chhatwal, Jasmeer P., Hedden, Trey, Mormino, Elizabeth C., Hanseeuw, Bernard J., Sepulcre, Jorge, Huijbers, Willem, LaPoint, Molly, Buckley, Rachel F., Johnson, Keith A., Sperling, Reisa A.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 19.04.2017
• Subjects: Aged; Aged, 80 and over; Amyloid beta-Peptides - metabolism; Brain - diagnostic imaging; Brain - metabolism; Brain - physiology; Connectome; Female; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Nerve Net - physiology; Peptide Fragments - metabolism; Positron-Emission Tomography; tau Proteins - metabolism; PiB; AV1451; Tau; amyloid; DMN; fcMRI

Alzheimer's disease (AD) is characterized by two hallmark molecular pathologies: amyloid aβ 1–42 and Tau neurofibrillary tangles. To date, studies of functional connectivity MRI (fcMRI) in individuals with preclinical AD have relied on associations with in vivo measures of amyloid pathology. Wi...