Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas - Brekke, Ranveig S; Gravdal, Anny; El Jellas, Khadija; Curry, Grace E; Lin, Jianguo; Wilhelm, Steven J; Steine, Solrun J; Mas, Eric; Johansson, Stefan; Lowe, Mark E; Johansson, Bente B; Xiao, Xunjun; et al. (Human molecular genetics, 2024)
Keywords: Alleles; Animals; Biochemistry, Molecular Biology; Cancer; Female; Gene Frequency; Genetics; Genomics; HEK293 Cells; Human genetics; Human health and pathology; Humans; Hépatology and Gastroenterology; Life Sciences; Lipase - genetics; Male; Mice; Minisatellite Repeats - genetics; Mutagenesis, Insertional - genetics; Original; Pancreas, Exocrine - enzymology; Pancreas, Exocrine - metabolism; Pancreatic Neoplasms - enzymology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; pancreatic cancer; variable number tandem repeat; single-base insertions; carboxyl ester lipase