The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory

• Published in: Anesthesia and analgesia Vol. 108; no. 1; pp. 90 - 104
• Main Authors: LOEPKE, Andreas W, ISTAPHANOUS, George K, DANZER, Steve C, MCAULIFFE, John J, MILES, Lili, HUGHES, Elizabeth A, MCCANN, John C, HARLOW, Kathryn E, KURTH, C. Dean, WILLIAMS, Michael T, VORHEES, Charles V
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 2009
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Inhalation - toxicity; Animals; Animals, Newborn; Apoptosis - drug effects; Behavior, Animal - drug effects; Biological and medical sciences; Blood Glucose - drug effects; Brain - drug effects; Brain - pathology; Brain - physiopathology; Carbon Dioxide - blood; Cell Survival - drug effects; Female; Glucose - administration & dosage; Hydrogen-Ion Concentration; Isoflurane - toxicity; Lactic Acid - blood; Male; Maze Learning - drug effects; Medical sciences; Memory - drug effects; Mice; Mice, Inbred C57BL; Motor Activity - drug effects; Nerve Degeneration - chemically induced; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Neurons - drug effects; Neurons - pathology; Oxygen - blood; Time Factors; Volatile compound; Human; Rodentia; Isoflurane; Encephalon; Learning; Vertebrata; Mammalia; Newborn; General anesthetic; Mouse; Animal; Anesthesia; Halogen Organic compounds

Volatile anesthetics, such as isoflurane, are widely used in infants and neonates. Neurodegeneration and neurocognitive impairment after exposure to isoflurane, midazolam, and nitrous oxide in neonatal rats have raised concerns regarding the safety of pediatric anesthesia. In neonatal mice, prolonge...