ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models

• Published in: Blood Vol. 137; no. 24; pp. 3365 - 3377
• Main Authors: Vaisitti, Tiziana, Arruga, Francesca, Vitale, Nicoletta, Lee, Thanh-Trang, Ko, Mira, Chadburn, Amy, Braggio, Esteban, Di Napoli, Arianna, Iannello, Andrea, Allan, John N., Miller, Langdon L., Lannutti, Brian J., Furman, Richard R., Jessen, Katti A., Deaglio, Silvia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.06.2021; American Society of Hematology
• Subjects: Lymphoid Neoplasia

Richter syndrome (RS) represents the transformation of chronic lymphocytic leukemia (CLL), typically to an aggressive lymphoma. Treatment options for RS are limited and the disease is often fatal. Receptor tyrosine kinase–like orphan receptor 1 (ROR1) is expressed on CLL cells and other cancers but...