The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation

• Published in: Blood Vol. 139; no. 4; pp. 584 - 596
• Main Authors: Amaya, Maria L., Inguva, Anagha, Pei, Shanshan, Jones, Courtney, Krug, Anna, Ye, Haobin, Minhajuddin, Mohammad, Winters, Amanda, Furtek, Steffanie L., Gamboni, Fabia, Stevens, Brett, D'Alessandro, Angelo, Pollyea, Daniel A., Reigan, Philip, Jordan, Craig T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.01.2022; American Society of Hematology
• Subjects: Amino Acid Transport System ASC - metabolism; Cell Survival; Humans; Leukemia, Myeloid, Acute - metabolism; Minor Histocompatibility Antigens - metabolism; Myeloid Neoplasia; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - metabolism; Oxidative Phosphorylation; Proto-Oncogene Proteins c-myc - metabolism; Signal Transduction; STAT3 Transcription Factor - metabolism; Tumor Cells, Cultured

Acute myeloid leukemia (AML) is characterized by the presence of leukemia stem cells (LSCs), and failure to fully eradicate this population contributes to disease persistence/relapse. Prior studies have characterized metabolic vulnerabilities of LSCs, which demonstrate preferential reliance on oxida...