CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case–control structured association study

• Published in: Human molecular genetics Vol. 14; no. 16; pp. 2421 - 2434
• Main Authors: Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.08.2005; Oxford Publishing Limited (England)
• Subjects: Adult; Alcoholism - genetics; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Case-Control Studies; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Haplotypes; Humans; Male; Medical sciences; Molecular and cellular biology; Mood Disorders - genetics; Oryza sativa; Receptor, Muscarinic M2 - genetics; Substance-Related Disorders - genetics; Toxicology; Drug; Affective disorder; Mood disorder; Regulation(control); Association; Gene; Alcoholism; Dependence; Genetics

Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. [Wang, J.C., Hinrichs, A.L., Stock, H., Budde, J., Allen, R., Bertelsen, S., Kwon, J.M., Wu, W., Dick, D.M., Rice, J. et al. (2004) Evidence of common a...