A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

• Published in: Cell discovery Vol. 6; no. 1; p. 35
• Main Authors: Liao, Hongwei, Li, Xiang, Zhao, Lianzheng, Wang, Yalong, Wang, Xiaodan, Wu, Ye, Zhou, Xin, Fu, Wei, Liu, Lei, Hu, Hong-Gang, Chen, Ye-Guang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 09.06.2020; Springer Nature B.V
• Subjects: 631/67/1059/153; 631/67/1059/602; Adenomatous polyposis coli; Biomedical and Life Sciences; Cancer; Cell Biology; Cell Culture; Cell Cycle Analysis; Cell Physiology; Chimeras; Colorectal cancer; Colorectal carcinoma; Degradation; Intestine; Life Sciences; Organoids; Peptides; Prostate cancer; Proteolysis; Stem Cells; Tumors; Wnt protein; β-Catenin

Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and progression of many types of tumors and thus β-catenin represents one attractive intracellular target for cancer therapy. Based on the Axin-derived peptide that binds to β-catenin, two stapled peptides SAHPA1 and x...