Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

• Published in: eLife Vol. 8
• Main Authors: Wang, Shixiang, He, Zaoke, Wang, Xuan, Li, Huimin, Liu, Xue-Song
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications, Ltd 26.11.2019; eLife Sciences Publications Ltd
• Subjects: antigen presentation; Antigen Presentation - immunology; B7-H1 Antigen; Biomarkers, Tumor - immunology; Cancer Biology; cancer immunotherapy; Genetics and Genomics; Humans; immune checkpoint inhibitors; Immunogenetics; Immunotherapy; Mutation; Neoplasms - immunology; Neoplasms - therapy; tumor immunogenicity; tumor mutational burden; genetics; antigen presentation; tumor mutational burden; cancer immunotherapy; genomics; cancer biology; immune checkpoint inhibitors; tumor immunogenicity; human

Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a small percentage of patients show response to ICI, and there is an unmet need for biomarkers that will identify patients who are more likely to respond to immunotherapy. The fun...