Convergent Findings for Abnormalities of the NF-κB Signaling Pathway in Schizophrenia

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 38; no. 3; pp. 533 - 539
• Main Authors: Roussos, Panos, Katsel, Pavel, Davis, Kenneth L, Giakoumaki, Stella G, Siever, Larry J, Bitsios, Panos, Haroutunian, Vahram
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.02.2013
• Subjects: Acoustic startle response; Adult and adolescent clinical studies; Animals; Axonogenesis; Biological and medical sciences; Chromosome translocations; Cognitive ability; Cohort Studies; Data processing; DNA microarrays; Down-Regulation - genetics; Gene expression; Humans; Male; Medical sciences; Mental disorders; Neural Pathways - pathology; NF- Kappa B protein; NF-kappa B - genetics; NF-kappa B - physiology; Nuclear transport; Original; Protein transport; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Quantitative trait loci; Rats; Rats, Sprague-Dawley; Reflexes; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - pathology; Signal transduction; Signal Transduction - genetics; Single-nucleotide polymorphism; Startle response; superior temporal gyrus; Temporal Lobe - metabolism; Temporal Lobe - pathology; Transcription factors; Psychosis; Temporal lobe; Signal transduction; Messenger RNA; Postmortem; Schizophrenia; importin; mRNA; Transcription factor NFκB; Transcription factor; Prepulse inhibition; superior temporal gyrus

Neurons exhibit a constitutive level of nuclear factor-κB (NF-κB) signaling and this pathway plays a significant role in neurite outgrowth, activity-dependent plasticity, and cognitive function. Transcription factor analysis was performed in a microarray data set profiled in four different brain reg...