Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist - Azumaya, Caleigh M.; Linton, Emily A.; Risener, Caitlin J.; Nakagawa, Terunaga; Karakas, Erkan (The Journal of biological chemistry, 2020)
Keywords: Binding Sites; calcium channel; calcium intracellular release; Calcium Signaling; cell signaling; cryo-electron microscopy; Cryoelectron Microscopy; Humans; Inositol 1,4,5-Trisphosphate - metabolism; Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors; Inositol 1,4,5-Trisphosphate Receptors - chemistry; Inositol 1,4,5-Trisphosphate Receptors - metabolism; Inositol 1,4,5-Trisphosphate Receptors - ultrastructure; inositol trisphosphate receptor (InsP3R); ion channel; isothermal titration calorimetry (ITC); Models, Molecular; Peptides - metabolism; Protein Conformation; Protein Structure and Folding; self-binding peptide; structural biology; calcium channel; ion channel; cell signaling; calcium intracellular release; inositol trisphosphate receptor (InsP3R); structural biology; self-binding peptide; isothermal titration calorimetry (ITC); cryo-electron microscopy