Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback

Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. However, the difficulty of controlling the composition of microbial consortia over time hinders their optimal use in many a...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 13; no. 1; p. 4808
Main Authors Gutiérrez Mena, Joaquín, Kumar, Sant, Khammash, Mustafa
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.08.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/1647/2253
631/326/2565/855
631/553/1745
631/553/2695
631/553/552
Automation
Bacteria
Biology
Cell culture
Composition
Control systems
Dynamic models
E coli
Feedback
Humanities and Social Sciences
Labor
Microorganisms
multidisciplinary
Optimal control
Robust control
Science
Science (multidisciplinary)
Strains (organisms)
Synthetic biology
Time measurement
Online AccessGet full text

Cover

Abstract Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. However, the difficulty of controlling the composition of microbial consortia over time hinders their optimal use in many applications. Here, we present a fully automated, high-throughput platform that combines real-time measurements and computer-controlled optogenetic modulation of bacterial growth to implement precise and robust compositional control of a two-strain E. coli community. In addition, we develop a general framework for dynamic modeling of synthetic genetic circuits in the physiological context of E. coli and use a host-aware model to determine the optimal control parameters of our closed-loop compositional control system. Our platform succeeds in stabilizing the strain ratio of multiple parallel co-cultures at arbitrary levels and in changing these targets over time, opening the door for the implementation of dynamic compositional programs in synthetic bacterial communities. Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.
AbstractList Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. However, the difficulty of controlling the composition of microbial consortia over time hinders their optimal use in many applications. Here, we present a fully automated, high-throughput platform that combines real-time measurements and computer-controlled optogenetic modulation of bacterial growth to implement precise and robust compositional control of a two-strain E. coli community. In addition, we develop a general framework for dynamic modeling of synthetic genetic circuits in the physiological context of E. coli and use a host-aware model to determine the optimal control parameters of our closed-loop compositional control system. Our platform succeeds in stabilizing the strain ratio of multiple parallel co-cultures at arbitrary levels and in changing these targets over time, opening the door for the implementation of dynamic compositional programs in synthetic bacterial communities.
Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. However, the difficulty of controlling the composition of microbial consortia over time hinders their optimal use in many applications. Here, we present a fully automated, high-throughput platform that combines real-time measurements and computer-controlled optogenetic modulation of bacterial growth to implement precise and robust compositional control of a two-strain E. coli community. In addition, we develop a general framework for dynamic modeling of synthetic genetic circuits in the physiological context of E. coli and use a host-aware model to determine the optimal control parameters of our closed-loop compositional control system. Our platform succeeds in stabilizing the strain ratio of multiple parallel co-cultures at arbitrary levels and in changing these targets over time, opening the door for the implementation of dynamic compositional programs in synthetic bacterial communities. Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.
Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. However, the difficulty of controlling the composition of microbial consortia over time hinders their optimal use in many applications. Here, we present a fully automated, high-throughput platform that combines real-time measurements and computer-controlled optogenetic modulation of bacterial growth to implement precise and robust compositional control of a two-strain E. coli community. In addition, we develop a general framework for dynamic modeling of synthetic genetic circuits in the physiological context of E. coli and use a host-aware model to determine the optimal control parameters of our closed-loop compositional control system. Our platform succeeds in stabilizing the strain ratio of multiple parallel co-cultures at arbitrary levels and in changing these targets over time, opening the door for the implementation of dynamic compositional programs in synthetic bacterial communities.Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.
Abstract Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. However, the difficulty of controlling the composition of microbial consortia over time hinders their optimal use in many applications. Here, we present a fully automated, high-throughput platform that combines real-time measurements and computer-controlled optogenetic modulation of bacterial growth to implement precise and robust compositional control of a two-strain E. coli community. In addition, we develop a general framework for dynamic modeling of synthetic genetic circuits in the physiological context of E. coli and use a host-aware model to determine the optimal control parameters of our closed-loop compositional control system. Our platform succeeds in stabilizing the strain ratio of multiple parallel co-cultures at arbitrary levels and in changing these targets over time, opening the door for the implementation of dynamic compositional programs in synthetic bacterial communities.
Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.
ArticleNumber 4808
Author Kumar, Sant
Gutiérrez Mena, Joaquín
Khammash, Mustafa
Author_xml – sequence: 1
  givenname: Joaquín
  orcidid: 0000-0001-8548-0442
  surname: Gutiérrez Mena
  fullname: Gutiérrez Mena, Joaquín
  organization: Department of Biosystems Science and Engineering (D-BSSE), ETH Zürich
– sequence: 2
  givenname: Sant
  orcidid: 0000-0002-4056-8501
  surname: Kumar
  fullname: Kumar, Sant
  organization: Department of Biosystems Science and Engineering (D-BSSE), ETH Zürich
– sequence: 3
  givenname: Mustafa
  orcidid: 0000-0002-4855-9220
  surname: Khammash
  fullname: Khammash, Mustafa
  email: mustafa.khammash@bsse.ethz.ch
  organization: Department of Biosystems Science and Engineering (D-BSSE), ETH Zürich
BookMark eNp9kk1v1DAQhi1UREvpH-AUiQuXgMcfcXxBQi0tlSpxgQMny7EnS5bEXuyk0vbX423KRzlgWfJ4_L6PxqN5To5CDEjIS6BvgPL2bRYgGlVTxmrOuGb13RNywqiAGhTjR3_Fx-Qs5y0ti2tohXhGjrnUimvNT8jXi32w0-Aqt-8wbTDgfLjEMKc4VrGvOutmTIMdS7J2yzgvCUs47WIe5iGG6nawVdzN8Ze3R_TF9P0FedrbMePZw3lKvlx--Hz-sb75dHV9_v6mdkKouRaILfi-bThYpmSPvZK-7YRXXACzVsuW81b2znLdSNSdb7RkDSipqBag-Cm5Xrk-2q3ZpWGyaW-iHcx9IqaNsakUNqJxQoOnkqsenPBMdujBM6S0sQI52sJ6t7J2Szehd1jaYMdH0McvYfhmNvHWaN6CVG0BvH4ApPhjwTybacgOx9EGjEs2TNHyLQUNFOmrf6TbuKRQWnVQla0EHFRsVbkUc07Y_y4GqDkMglkHwZRBMPeDYO6Kia-mXMRhg-kP-j-un-mxtzs
CitedBy_id crossref_primary_10_1039_D3SC04815B
crossref_primary_10_1002_bit_28575
crossref_primary_10_1038_s41467_024_46410_9
crossref_primary_10_34133_bdr_0037
crossref_primary_10_3389_fbioe_2022_957140
crossref_primary_10_1002_advs_202310079
crossref_primary_10_3389_fmicb_2023_1117559
crossref_primary_10_1016_j_copbio_2023_102974
crossref_primary_10_1039_D2LC00716A
crossref_primary_10_1016_j_engmic_2023_100103
crossref_primary_10_3389_fbioe_2022_1029403
crossref_primary_10_3389_fmicb_2024_1368377
crossref_primary_10_1021_acssynbio_3c00215
crossref_primary_10_1016_j_biotechadv_2024_108349
crossref_primary_10_1016_j_cofs_2023_101074
crossref_primary_10_1128_msphere_00547_22
crossref_primary_10_1038_s41598_023_40469_y
crossref_primary_10_1016_j_copbio_2024_103126
crossref_primary_10_1021_acssynbio_3c00761
crossref_primary_10_1016_j_copbio_2023_102893
crossref_primary_10_1016_j_mib_2023_102404
crossref_primary_10_1038_s41467_023_36670_2
crossref_primary_10_1371_journal_pcbi_1011638
crossref_primary_10_1093_jambio_lxae158
Cites_doi 10.1038/nbt.3095
10.1016/j.copbio.2019.09.011
10.1038/ncomms12546
10.1038/s41467-021-23336-0
10.1073/pnas.1506781112
10.1371/journal.pcbi.1009877
10.1021/acssynbio.6b00220
10.1038/s41467-020-17475-z
10.1109/LCSYS.2021.3086234
10.1038/nmicrobiol.2017.83
10.1073/pnas.1711842115
10.1186/1754-1611-4-10
10.1038/s41467-019-12027-6
10.1073/pnas.1008685107
10.1038/msb.2010.66
10.15252/msb.20167456
10.1021/acssynbio.1c00182
10.1126/science.aaw0542
10.1038/nmeth.3339
10.1021/acssynbio.6b00002
10.1021/acssynbio.6b00040
10.1038/s41467-021-25754-6
10.1073/pnas.1416533112
10.1002/biot.202100169
10.1002/biot.201600013
10.1038/nmeth.4635
10.1016/j.tim.2020.05.010
10.1038/s41467-022-31033-9
10.1016/0378-1119(94)90856-7
10.1128/jb.172.11.6557-6567.1990
10.1038/s41589-018-0091-7
10.1021/acssynbio.1c00131
10.1038/s42003-020-01409-y
10.1186/s12934-019-1083-3
10.1021/acssynbio.7b00169
10.1038/nchembio.2514
10.1002/cpmb.115
10.1111/1751-7915.12855
10.15252/msb.20156382
10.1126/science.aaa3794
10.1038/ismej.2009.88
10.1073/pnas.1716888115
10.1128/AAC.18.2.323
10.1016/j.cels.2022.02.004
10.1021/acssynbio.8b00333
10.1016/j.tibtech.2018.11.002
10.1038/s41565-021-00878-4
10.1038/nbt.2018
10.1038/s41467-019-08890-y
10.1038/nmeth.2515
10.1038/s41467-020-15056-8
10.1371/journal.pcbi.1004685
10.1126/science.131.3409.1292
10.1038/nrmicro.2016.84
10.1016/j.mib.2018.11.007
10.1038/nmeth.1318
10.1038/ismej.2016.26
10.15252/msb.20145379
10.1021/acssynbio.6b00361
10.1038/s41564-022-01072-5
10.1016/j.mib.2021.07.005
10.1038/s41467-021-22240-x
10.1128/AEM.00908-10
10.1126/science.1192588
10.1038/nbt.4151
10.1038/nature09565
10.1016/j.tim.2021.04.001
10.7554/eLife.74540
10.1038/msb.2008.24
10.1101/614529
10.1038/s41564-017-0022-5
10.1002/adbi.202000256
10.1109/CDC40024.2019.9030209
10.1101/2022.02.18.480836
10.1101/2021.08.03.454926
ContentType Journal Article
Copyright The Author(s) 2022
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2022
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-022-32392-z
DatabaseName Springer Nature OA Free Journals
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

Publicly Available Content Database

CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 4808
ExternalDocumentID oai_doaj_org_article_c491d0537f1c4d25bed1d2e006a4e3ea
10_1038_s41467_022_32392_z
GrantInformation_xml – fundername: EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
  grantid: 743269; 766840; 743269; 766840; 743269; 766840
  funderid: https://doi.org/10.13039/100010663
– fundername: ;
  grantid: 743269; 766840; 743269; 766840; 743269; 766840
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AAYXX
CITATION
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
SOI
7X8
AFGXO
5PM
ID FETCH-LOGICAL-c447t-4ee81df8631a275fef75d8b4d73412aa9583385fca3965e9bd695261757094173
IEDL.DBID RPM
ISSN 2041-1723
IngestDate Fri Oct 04 13:13:01 EDT 2024
Tue Sep 17 21:11:04 EDT 2024
Fri Aug 16 09:46:57 EDT 2024
Thu Oct 10 20:00:15 EDT 2024
Wed Oct 02 14:39:33 EDT 2024
Fri Oct 11 20:46:56 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c447t-4ee81df8631a275fef75d8b4d73412aa9583385fca3965e9bd695261757094173
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-4855-9220
0000-0002-4056-8501
0000-0001-8548-0442
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381578/
PMID 35973993
PQID 2702707411
PQPubID 546298
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_c491d0537f1c4d25bed1d2e006a4e3ea
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9381578
proquest_miscellaneous_2703417161
proquest_journals_2702707411
crossref_primary_10_1038_s41467_022_32392_z
springer_journals_10_1038_s41467_022_32392_z
PublicationCentury 2000
PublicationDate 2022-08-16
PublicationDateYYYYMMDD 2022-08-16
PublicationDate_xml – month: 08
  year: 2022
  text: 2022-08-16
  day: 16
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Zuñiga, Zaramela, Zengler (CR4) 2017; 10
Ceroni (CR43) 2018; 15
Herrero, De Lorenzo, Timmis (CR74) 1990; 172
Stephens, Pozo, Tsao, Hauk, Bentley (CR33) 2019; 10
Scott, Klumpp, Mateescu, Hwa (CR54) 2014; 10
CR39
Chen, Kim, Hirning, Josić, Bennett (CR32) 2015; 349
Kumar, Rullan, Khammash (CR42) 2021; 12
Perry, Nelson, Timp (CR15) 2016; 5
Miano, Liao, Hasty (CR29) 2020; 11
Villarreal (CR66) 2018; 14
Macia (CR14) 2016; 12
CR31
Liu, Tokuyasu, Fu, Liu (CR9) 2021; 63
Wong, Mancuso, Kiriakov, Bashor, Khalil (CR53) 2018; 36
CR70
Weiße, Oyarzún, Danos, Swain (CR67) 2015; 112
Ceroni, Algar, Stan, Ellis (CR23) 2015; 12
Kusuda, Shimizu, Toya (CR45) 2021; 16
Zhang, Stephanopoulos (CR37) 2016; 11
Tsoi (CR25) 2018; 115
Grandel, Reyes Gamas, Bennett (CR27) 2021; 29
Gibson (CR72) 2009; 6
Vega, Gore (CR10) 2018; 45
Potapov (CR76) 2018; 7
Konopka (CR2) 2009; 3
Zhang, Pereira, Li, Stephanopoulos (CR24) 2015; 112
Terrell (CR46) 2021; 16
Harvey, Koch (CR49) 1980; 18
Hasan, Koob, Szybalsk (CR75) 1994; 150
Milias-Argeitis (CR40) 2011; 29
Liao, Din, Tsimring, Hasty (CR63) 2019; 365
Bar-On, Phillips, Milo (CR1) 2018; 115
Van Vliet, Hauert, Fridberg, Ackermann, Co (CR5) 2022; 18
Bulkley, Innis, Blaha, Steitz (CR48) 2010; 107
Wintermute, Silver (CR6) 2010; 6
Borer, Ciccarese, Johnson, Or (CR8) 2020; 3
Zhang, van Kleunen, Becks, Thakur (CR11) 2020; 28
Fiore (CR17) 2017; 6
Zhou, Qiao, Edgar, Stephanopoulos (CR20) 2015; 33
CR59
Hardin (CR28) 1960; 131
Olson, Tzouanas, Tabor (CR56) 2017; 13
Fedorec, Karkaria, Sulu, Barnes (CR35) 2021; 12
Nadell, Drescher, Foster (CR3) 2016; 14
CR55
Marillonnet, Grützner (CR77) 2020; 130
CR52
Roell (CR18) 2019; 18
Shaw (CR50) 1983; 14
Benzinger, Ovinnikov, Khammash (CR57) 2022; 13
Bertaux (CR44) 2022; 13
Qian, Huang, Jiménez, Del Vecchio (CR69) 2017; 6
Sgobba, Wendisch (CR19) 2020; 62
Izard (CR65) 2015; 11
Li (CR16) 2021; 12
Milias-Argeitis, Rullan, Aoki, Buchmann, Khammash (CR41) 2016; 7
Tamsir, Tabor, Voigt (CR13) 2011; 469
Scott (CR30) 2017; 2
Scott, Gunderson, Mateescu, Zhang, Hwa (CR47) 2010; 330
CR22
Lalwani, Kawabe, Mays, Hoffman, Avalos (CR38) 2021; 10
Shin, McClendon, Vo, Chen (CR36) 2010; 76
Alnahhas (CR34) 2020; 11
Fiore, Rossa, Guarino, Bernardo (CR62) 2022; 6
CR64
Yu (CR7) 2022; 7
McCarty, Ledesma-Amaro (CR12) 2019; 37
CR61
CR60
Angulo, Moog, Liu (CR58) 2019; 10
Chen (CR78) 2013; 10
Gorochowski, Avcilar-Kucukgoze, Bovenberg, Roubos, Ignatova (CR68) 2016; 5
Kong, Meldgin, Collins, Lu (CR21) 2018; 14
Lindemann (CR26) 2016; 10
Cox, Dunlop, Elowitz (CR73) 2010; 4
Baumschlager, Aoki, Khammash (CR51) 2017; 6
Santos-Navarro, Vignoni, Boada, Picó (CR71) 2021; 10
S Marillonnet (32392_CR77) 2020; 130
D Bulkley (32392_CR48) 2010; 107
M Scott (32392_CR54) 2014; 10
E Sgobba (32392_CR19) 2020; 62
G Hardin (32392_CR28) 1960; 131
AY Weiße (32392_CR67) 2015; 112
S Kumar (32392_CR42) 2021; 12
RJ Harvey (32392_CR49) 1980; 18
32392_CR39
M Kusuda (32392_CR45) 2021; 16
WV Shaw (32392_CR50) 1983; 14
NS McCarty (32392_CR12) 2019; 37
RS Cox (32392_CR73) 2010; 4
MT Angulo (32392_CR58) 2019; 10
NE Grandel (32392_CR27) 2021; 29
D Benzinger (32392_CR57) 2022; 13
Z Zhang (32392_CR11) 2020; 28
F Ceroni (32392_CR43) 2018; 15
H Zhang (32392_CR24) 2015; 112
D Fiore (32392_CR62) 2022; 6
YJ Chen (32392_CR78) 2013; 10
N Hasan (32392_CR75) 1994; 150
W Kong (32392_CR21) 2018; 14
A Milias-Argeitis (32392_CR40) 2011; 29
A Tamsir (32392_CR13) 2011; 469
A Miano (32392_CR29) 2020; 11
SR Scott (32392_CR30) 2017; 2
K Zhou (32392_CR20) 2015; 33
EJ Olson (32392_CR56) 2017; 13
HD Shin (32392_CR36) 2010; 76
32392_CR52
FN Santos-Navarro (32392_CR71) 2021; 10
X Li (32392_CR16) 2021; 12
B Borer (32392_CR8) 2020; 3
YM Bar-On (32392_CR1) 2018; 115
J Macia (32392_CR14) 2016; 12
F Villarreal (32392_CR66) 2018; 14
S Van Vliet (32392_CR5) 2022; 18
JS Yu (32392_CR7) 2022; 7
RN Alnahhas (32392_CR34) 2020; 11
DG Gibson (32392_CR72) 2009; 6
C Zuñiga (32392_CR4) 2017; 10
32392_CR55
A Konopka (32392_CR2) 2009; 3
JL Terrell (32392_CR46) 2021; 16
32392_CR59
F Bertaux (32392_CR44) 2022; 13
32392_CR60
V Potapov (32392_CR76) 2018; 7
H Zhang (32392_CR37) 2016; 11
K Stephens (32392_CR33) 2019; 10
32392_CR64
32392_CR61
Y Qian (32392_CR69) 2017; 6
M Herrero (32392_CR74) 1990; 172
NM Vega (32392_CR10) 2018; 45
MJ Liao (32392_CR63) 2019; 365
CD Nadell (32392_CR3) 2016; 14
AJ Fedorec (32392_CR35) 2021; 12
EH Wintermute (32392_CR6) 2010; 6
W Liu (32392_CR9) 2021; 63
A Milias-Argeitis (32392_CR41) 2016; 7
32392_CR22
MA Lalwani (32392_CR38) 2021; 10
M Scott (32392_CR47) 2010; 330
TE Gorochowski (32392_CR68) 2016; 5
32392_CR70
F Ceroni (32392_CR23) 2015; 12
A Baumschlager (32392_CR51) 2017; 6
32392_CR31
J Izard (32392_CR65) 2015; 11
G Fiore (32392_CR17) 2017; 6
R Tsoi (32392_CR25) 2018; 115
Y Chen (32392_CR32) 2015; 349
BG Wong (32392_CR53) 2018; 36
N Perry (32392_CR15) 2016; 5
GW Roell (32392_CR18) 2019; 18
SR Lindemann (32392_CR26) 2016; 10
References_xml – ident: CR70
– volume: 33
  start-page: 377
  year: 2015
  end-page: 383
  ident: CR20
  article-title: Distributing a metabolic pathway among a microbial consortium enhances production of natural products
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3095
  contributor:
    fullname: Stephanopoulos
– ident: CR22
– volume: 62
  start-page: 72
  year: 2020
  end-page: 79
  ident: CR19
  article-title: Synthetic microbial consortia for small molecule production
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2019.09.011
  contributor:
    fullname: Wendisch
– volume: 7
  year: 2016
  ident: CR41
  article-title: Automated optogenetic feedback control for precise and robust regulation of gene expression and cell growth
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12546
  contributor:
    fullname: Khammash
– volume: 12
  year: 2021
  ident: CR16
  article-title: Synthetic neural-like computing in microbial consortia for pattern recognition
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-23336-0
  contributor:
    fullname: Li
– volume: 112
  start-page: 8266
  year: 2015
  end-page: 8271
  ident: CR24
  article-title: Engineering coculture systems for the production of biochemical products
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1506781112
  contributor:
    fullname: Stephanopoulos
– ident: CR39
– volume: 18
  start-page: e1009877
  year: 2022
  ident: CR5
  article-title: Global dynamics of microbial communities emerge from local interaction rules
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1009877
  contributor:
    fullname: Co
– volume: 14
  start-page: 1
  year: 1983
  end-page: 46
  ident: CR50
  article-title: Chloramphenicol acetyltransferase: enzymology and molecular biolog
  publication-title: Critical Rev. Biochem. Mol. Biol.
  contributor:
    fullname: Shaw
– volume: 6
  start-page: 507
  year: 2017
  end-page: 517
  ident: CR17
  article-title: In-silico analysis and implementation of a multicellular feedback control strategy in a synthetic bacterial consortium
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00220
  contributor:
    fullname: Fiore
– volume: 11
  start-page: 1
  year: 2020
  end-page: 10
  ident: CR34
  article-title: Majority sensing in synthetic microbial consortia
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17475-z
  contributor:
    fullname: Alnahhas
– volume: 6
  start-page: 800
  year: 2022
  end-page: 805
  ident: CR62
  article-title: Feedback ratiometric control of two microbial populations in a single chemostat
  publication-title: IEEE Control Syst. Lett.
  doi: 10.1109/LCSYS.2021.3086234
  contributor:
    fullname: Bernardo
– volume: 2
  start-page: 17083
  year: 2017
  ident: CR30
  article-title: A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis
  publication-title: Nat. Microbiol.
  doi: 10.1038/nmicrobiol.2017.83
  contributor:
    fullname: Scott
– volume: 115
  start-page: 6506
  year: 2018
  end-page: 6511
  ident: CR1
  article-title: The biomass distribution on Earth
  publication-title: Proc. Natl Acad Sci. USA
  doi: 10.1073/pnas.1711842115
  contributor:
    fullname: Milo
– ident: CR61
– volume: 4
  start-page: 1
  year: 2010
  end-page: 12
  ident: CR73
  article-title: A synthetic three-color scaffold for monitoring genetic regulation and noise
  publication-title: J. Biol. Eng.
  doi: 10.1186/1754-1611-4-10
  contributor:
    fullname: Elowitz
– volume: 10
  year: 2019
  ident: CR33
  article-title: Bacterial co-culture with cell signaling translator and growth controller modules for autonomously regulated culture composition
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12027-6
  contributor:
    fullname: Bentley
– volume: 107
  start-page: 17158
  year: 2010
  end-page: 17163
  ident: CR48
  article-title: Revisiting the structures of several antibiotics bound to the bacterial ribosome
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1008685107
  contributor:
    fullname: Steitz
– volume: 6
  start-page: 407
  year: 2010
  ident: CR6
  article-title: Emergent cooperation in microbial metabolism
  publication-title: Mol. Syst. Biol.
  doi: 10.1038/msb.2010.66
  contributor:
    fullname: Silver
– volume: 13
  start-page: 926
  year: 2017
  ident: CR56
  article-title: A photoconversion model for full spectral programming and multiplexing of optogenetic systems
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20167456
  contributor:
    fullname: Tabor
– volume: 10
  start-page: 2015
  year: 2021
  end-page: 2029
  ident: CR38
  article-title: Optogenetic control of microbial consortia populations for chemical production
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.1c00182
  contributor:
    fullname: Avalos
– volume: 365
  start-page: 1045
  year: 2019
  end-page: 1049
  ident: CR63
  article-title: Rock-paper-scissors: engineered population dynamics increase genetic stability
  publication-title: Science
  doi: 10.1126/science.aaw0542
  contributor:
    fullname: Hasty
– volume: 12
  start-page: 1
  year: 2015
  end-page: 8
  ident: CR23
  article-title: Quantifying cellular capacity identifies gene expression designs with reduced burden
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3339
  contributor:
    fullname: Ellis
– volume: 5
  start-page: 1421
  year: 2016
  end-page: 1432
  ident: CR15
  article-title: Wiring together synthetic bacterial consortia to create a biological integrated circuit
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00002
  contributor:
    fullname: Timp
– volume: 5
  start-page: 710
  year: 2016
  end-page: 720
  ident: CR68
  article-title: A minimal model of ribosome allocation dynamics captures trade-offs in expression between endogenous and synthetic genes
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00040
  contributor:
    fullname: Ignatova
– volume: 12
  start-page: 1
  year: 2021
  end-page: 13
  ident: CR42
  article-title: Rapid prototyping and design of cybergenetic single-cell controllers
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-25754-6
  contributor:
    fullname: Khammash
– volume: 112
  start-page: E1038
  year: 2015
  end-page: E1047
  ident: CR67
  article-title: Mechanistic links between cellular trade-offs, gene expression, and growth
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1416533112
  contributor:
    fullname: Swain
– volume: 16
  start-page: 2100169
  year: 2021
  ident: CR45
  article-title: Reactor control system in bacterial co-culture based on fluorescent proteins using an Arduino-based home-made device
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.202100169
  contributor:
    fullname: Toya
– volume: 11
  start-page: 981
  year: 2016
  end-page: 987
  ident: CR37
  article-title: Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.201600013
  contributor:
    fullname: Stephanopoulos
– volume: 15
  start-page: 387
  year: 2018
  end-page: 393
  ident: CR43
  article-title: Burden-driven feedback control of gene expression
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4635
  contributor:
    fullname: Ceroni
– ident: CR60
– volume: 28
  start-page: 783
  year: 2020
  end-page: 785
  ident: CR11
  article-title: Towards a general understanding of bacterial interactions
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2020.05.010
  contributor:
    fullname: Thakur
– volume: 13
  start-page: 1
  year: 2022
  end-page: 12
  ident: CR44
  article-title: Enhancing bioreactor arrays for automated measurements and reactive control with ReacSight
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31033-9
  contributor:
    fullname: Bertaux
– ident: CR64
– volume: 150
  start-page: 51
  year: 1994
  end-page: 56
  ident: CR75
  article-title: Escherichia coli genome targeting I. Cre-Zox-mediated in vitro generation of ori- plasmids and their in vivo chromosomal integration and retrieval
  publication-title: Gene
  doi: 10.1016/0378-1119(94)90856-7
  contributor:
    fullname: Szybalsk
– volume: 172
  start-page: 6557
  year: 1990
  end-page: 6567
  ident: CR74
  article-title: Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria
  publication-title: J. Bacteriol.
  doi: 10.1128/jb.172.11.6557-6567.1990
  contributor:
    fullname: Timmis
– volume: 14
  start-page: 821
  year: 2018
  end-page: 829
  ident: CR21
  article-title: Designing microbial consortia with defined social interactions
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-018-0091-7
  contributor:
    fullname: Lu
– volume: 10
  start-page: 3290
  year: 2021
  end-page: 3303
  ident: CR71
  article-title: RBS and promoter strengths determine the cell-growth-dependent protein mass fractions and their optimal synthesis rates
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.1c00131
  contributor:
    fullname: Picó
– volume: 3
  start-page: 1
  year: 2020
  end-page: 10
  ident: CR8
  article-title: Spatial organization in microbial range expansion emerges from trophic dependencies and successful lineages
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-020-01409-y
  contributor:
    fullname: Or
– volume: 18
  start-page: 1
  year: 2019
  end-page: 11
  ident: CR18
  article-title: Engineering microbial consortia by division of labor
  publication-title: Microbial Cell Factories
  doi: 10.1186/s12934-019-1083-3
  contributor:
    fullname: Roell
– volume: 6
  start-page: 2157
  year: 2017
  end-page: 2167
  ident: CR51
  article-title: Dynamic blue light-inducible T7 RNA polymerases (opto-T7RNAPs) for precise spatiotemporal gene expression control
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.7b00169
  contributor:
    fullname: Khammash
– volume: 14
  start-page: 29
  year: 2018
  end-page: 35
  ident: CR66
  article-title: Synthetic microbial consortia enable rapid assembly of pure translation machinery
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2514
  contributor:
    fullname: Villarreal
– volume: 130
  start-page: e115
  year: 2020
  ident: CR77
  article-title: Synthetic DNA assembly using golden gate cloning and the hierarchical modular cloning pipeline
  publication-title: Curr. Protoc. Mol. Biol.
  doi: 10.1002/cpmb.115
  contributor:
    fullname: Grützner
– volume: 10
  start-page: 1500
  year: 2017
  end-page: 1522
  ident: CR4
  article-title: Elucidation of complexity and prediction of interactions in microbial communities
  publication-title: Microbial Biotechnol.
  doi: 10.1111/1751-7915.12855
  contributor:
    fullname: Zengler
– volume: 11
  start-page: 840
  year: 2015
  ident: CR65
  article-title: A synthetic growth switch based on controlled expression of RNA polymerase
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20156382
  contributor:
    fullname: Izard
– volume: 349
  start-page: 986
  year: 2015
  end-page: 989
  ident: CR32
  article-title: Emergent genetic oscillations in a synthetic microbial consortium
  publication-title: Science
  doi: 10.1126/science.aaa3794
  contributor:
    fullname: Bennett
– volume: 3
  start-page: 1223
  year: 2009
  end-page: 1230
  ident: CR2
  article-title: What is microbial community ecology?
  publication-title: ISME J.
  doi: 10.1038/ismej.2009.88
  contributor:
    fullname: Konopka
– volume: 115
  start-page: 2526
  year: 2018
  end-page: 2531
  ident: CR25
  article-title: Metabolic division of labor in microbial systems
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1716888115
  contributor:
    fullname: Tsoi
– volume: 18
  start-page: 323
  year: 1980
  end-page: 337
  ident: CR49
  article-title: How partially inhibitory concentrations of chloramphenicol affect the growth of
  publication-title: Antimicrobial Agents Chemotherapy
  doi: 10.1128/AAC.18.2.323
  contributor:
    fullname: Koch
– volume: 13
  start-page: 353
  year: 2022
  end-page: 364
  ident: CR57
  article-title: Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2022.02.004
  contributor:
    fullname: Khammash
– volume: 7
  start-page: 2665
  year: 2018
  end-page: 2674
  ident: CR76
  article-title: Comprehensive profiling of four base overhang ligation fidelity by T4 DNA ligase and application to DNA assembly
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.8b00333
  contributor:
    fullname: Potapov
– volume: 37
  start-page: 181
  year: 2019
  end-page: 197
  ident: CR12
  article-title: Synthetic biology tools to engineer microbial communities for biotechnology
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2018.11.002
  contributor:
    fullname: Ledesma-Amaro
– volume: 16
  start-page: 688
  year: 2021
  end-page: 697
  ident: CR46
  article-title: Bioelectronic control of a microbial community using surface-assembled electrogenetic cells to route signals
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/s41565-021-00878-4
  contributor:
    fullname: Terrell
– volume: 29
  start-page: 1114
  year: 2011
  end-page: 1116
  ident: CR40
  article-title: In silico feedback for in vivo regulation of a gene expression circuit
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2018
  contributor:
    fullname: Milias-Argeitis
– volume: 10
  year: 2019
  ident: CR58
  article-title: A theoretical framework for controlling complex microbial communities
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08890-y
  contributor:
    fullname: Liu
– volume: 10
  start-page: 659
  year: 2013
  end-page: 664
  ident: CR78
  article-title: Characterization of 582 natural and synthetic terminators and quantification of their design constraints
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2515
  contributor:
    fullname: Chen
– volume: 11
  start-page: 1
  year: 2020
  end-page: 8
  ident: CR29
  article-title: Inducible cell-to-cell signaling for tunable dynamics in microbial communities
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-15056-8
  contributor:
    fullname: Hasty
– volume: 12
  start-page: e1004685
  year: 2016
  ident: CR14
  article-title: Implementation of complex biological logic circuits using spatially distributed multicellular consortia
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1004685
  contributor:
    fullname: Macia
– volume: 131
  start-page: 1292
  year: 1960
  end-page: 1297
  ident: CR28
  article-title: The competitive exclusion principle
  publication-title: Science
  doi: 10.1126/science.131.3409.1292
  contributor:
    fullname: Hardin
– volume: 14
  start-page: 589
  year: 2016
  end-page: 600
  ident: CR3
  article-title: Spatial structure, cooperation and competition in biofilms
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2016.84
  contributor:
    fullname: Foster
– ident: CR52
– volume: 45
  start-page: 195
  year: 2018
  end-page: 202
  ident: CR10
  article-title: Simple organizing principles in microbial communities
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2018.11.007
  contributor:
    fullname: Gore
– ident: CR31
– volume: 6
  start-page: 343
  year: 2009
  end-page: 345
  ident: CR72
  article-title: Enzymatic assembly of DNA molecules up to several hundred kilobases
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1318
  contributor:
    fullname: Gibson
– volume: 10
  start-page: 2077
  year: 2016
  end-page: 2084
  ident: CR26
  article-title: Engineering microbial consortia for controllable outputs
  publication-title: ISME J.
  doi: 10.1038/ismej.2016.26
  contributor:
    fullname: Lindemann
– volume: 10
  start-page: 747
  year: 2014
  ident: CR54
  article-title: Emergence of robust growth laws from optimal regulation of ribosome synthesis
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20145379
  contributor:
    fullname: Hwa
– ident: CR55
– volume: 6
  start-page: 1263
  year: 2017
  end-page: 1272
  ident: CR69
  article-title: Resource competition shapes the response of genetic circuits
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00361
  contributor:
    fullname: Del Vecchio
– volume: 7
  start-page: 542
  year: 2022
  end-page: 555
  ident: CR7
  article-title: Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-022-01072-5
  contributor:
    fullname: Yu
– ident: CR59
– volume: 63
  start-page: 109
  year: 2021
  end-page: 116
  ident: CR9
  article-title: The spatial organization of microbial communities during range expansion
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2021.07.005
  contributor:
    fullname: Liu
– volume: 12
  year: 2021
  ident: CR35
  article-title: Single strain control of microbial consortia
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-22240-x
  contributor:
    fullname: Barnes
– volume: 76
  start-page: 8150
  year: 2010
  end-page: 8159
  ident: CR36
  article-title: binary culture engineered for direct fermentation of hemicellulose to a biofuel
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.00908-10
  contributor:
    fullname: Chen
– volume: 330
  start-page: 1099
  year: 2010
  end-page: 1102
  ident: CR47
  article-title: Interdependence of cell growth and gene expression: origins and consequences
  publication-title: Science
  doi: 10.1126/science.1192588
  contributor:
    fullname: Hwa
– volume: 36
  start-page: 614
  year: 2018
  end-page: 623
  ident: CR53
  article-title: Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4151
  contributor:
    fullname: Khalil
– volume: 469
  start-page: 212
  year: 2011
  end-page: 215
  ident: CR13
  article-title: Robust multicellular computing using genetically encoded NOR gates and chemical ’wires’
  publication-title: Nature
  doi: 10.1038/nature09565
  contributor:
    fullname: Voigt
– volume: 29
  start-page: 1095
  year: 2021
  end-page: 1105
  ident: CR27
  article-title: Control of synthetic microbial consortia in time, space, and composition
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2021.04.001
  contributor:
    fullname: Bennett
– volume: 28
  start-page: 783
  year: 2020
  ident: 32392_CR11
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2020.05.010
  contributor:
    fullname: Z Zhang
– ident: 32392_CR22
  doi: 10.7554/eLife.74540
– ident: 32392_CR31
  doi: 10.1038/msb.2008.24
– volume: 469
  start-page: 212
  year: 2011
  ident: 32392_CR13
  publication-title: Nature
  doi: 10.1038/nature09565
  contributor:
    fullname: A Tamsir
– volume: 10
  start-page: 1500
  year: 2017
  ident: 32392_CR4
  publication-title: Microbial Biotechnol.
  doi: 10.1111/1751-7915.12855
  contributor:
    fullname: C Zuñiga
– volume: 10
  start-page: 2015
  year: 2021
  ident: 32392_CR38
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.1c00182
  contributor:
    fullname: MA Lalwani
– volume: 29
  start-page: 1114
  year: 2011
  ident: 32392_CR40
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2018
  contributor:
    fullname: A Milias-Argeitis
– volume: 18
  start-page: e1009877
  year: 2022
  ident: 32392_CR5
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1009877
  contributor:
    fullname: S Van Vliet
– volume: 16
  start-page: 2100169
  year: 2021
  ident: 32392_CR45
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.202100169
  contributor:
    fullname: M Kusuda
– volume: 10
  year: 2019
  ident: 32392_CR58
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08890-y
  contributor:
    fullname: MT Angulo
– ident: 32392_CR64
  doi: 10.1101/614529
– volume: 115
  start-page: 2526
  year: 2018
  ident: 32392_CR25
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1716888115
  contributor:
    fullname: R Tsoi
– volume: 10
  year: 2019
  ident: 32392_CR33
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12027-6
  contributor:
    fullname: K Stephens
– volume: 3
  start-page: 1223
  year: 2009
  ident: 32392_CR2
  publication-title: ISME J.
  doi: 10.1038/ismej.2009.88
  contributor:
    fullname: A Konopka
– volume: 12
  start-page: 1
  year: 2015
  ident: 32392_CR23
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3339
  contributor:
    fullname: F Ceroni
– volume: 107
  start-page: 17158
  year: 2010
  ident: 32392_CR48
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1008685107
  contributor:
    fullname: D Bulkley
– volume: 15
  start-page: 387
  year: 2018
  ident: 32392_CR43
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4635
  contributor:
    fullname: F Ceroni
– ident: 32392_CR61
– volume: 45
  start-page: 195
  year: 2018
  ident: 32392_CR10
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2018.11.007
  contributor:
    fullname: NM Vega
– volume: 150
  start-page: 51
  year: 1994
  ident: 32392_CR75
  publication-title: Gene
  doi: 10.1016/0378-1119(94)90856-7
  contributor:
    fullname: N Hasan
– volume: 14
  start-page: 589
  year: 2016
  ident: 32392_CR3
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2016.84
  contributor:
    fullname: CD Nadell
– ident: 32392_CR70
  doi: 10.1038/s41564-017-0022-5
– volume: 14
  start-page: 1
  year: 1983
  ident: 32392_CR50
  publication-title: Critical Rev. Biochem. Mol. Biol.
  contributor:
    fullname: WV Shaw
– volume: 11
  start-page: 981
  year: 2016
  ident: 32392_CR37
  publication-title: Biotechnol. J.
  doi: 10.1002/biot.201600013
  contributor:
    fullname: H Zhang
– ident: 32392_CR52
  doi: 10.1002/adbi.202000256
– volume: 76
  start-page: 8150
  year: 2010
  ident: 32392_CR36
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.00908-10
  contributor:
    fullname: HD Shin
– volume: 11
  start-page: 1
  year: 2020
  ident: 32392_CR34
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17475-z
  contributor:
    fullname: RN Alnahhas
– volume: 6
  start-page: 507
  year: 2017
  ident: 32392_CR17
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00220
  contributor:
    fullname: G Fiore
– volume: 172
  start-page: 6557
  year: 1990
  ident: 32392_CR74
  publication-title: J. Bacteriol.
  doi: 10.1128/jb.172.11.6557-6567.1990
  contributor:
    fullname: M Herrero
– volume: 36
  start-page: 614
  year: 2018
  ident: 32392_CR53
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4151
  contributor:
    fullname: BG Wong
– volume: 62
  start-page: 72
  year: 2020
  ident: 32392_CR19
  publication-title: Curr. Opin. Biotechnol.
  doi: 10.1016/j.copbio.2019.09.011
  contributor:
    fullname: E Sgobba
– volume: 14
  start-page: 821
  year: 2018
  ident: 32392_CR21
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-018-0091-7
  contributor:
    fullname: W Kong
– volume: 18
  start-page: 323
  year: 1980
  ident: 32392_CR49
  publication-title: Antimicrobial Agents Chemotherapy
  doi: 10.1128/AAC.18.2.323
  contributor:
    fullname: RJ Harvey
– volume: 5
  start-page: 1421
  year: 2016
  ident: 32392_CR15
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00002
  contributor:
    fullname: N Perry
– volume: 7
  start-page: 542
  year: 2022
  ident: 32392_CR7
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-022-01072-5
  contributor:
    fullname: JS Yu
– volume: 131
  start-page: 1292
  year: 1960
  ident: 32392_CR28
  publication-title: Science
  doi: 10.1126/science.131.3409.1292
  contributor:
    fullname: G Hardin
– volume: 349
  start-page: 986
  year: 2015
  ident: 32392_CR32
  publication-title: Science
  doi: 10.1126/science.aaa3794
  contributor:
    fullname: Y Chen
– volume: 130
  start-page: e115
  year: 2020
  ident: 32392_CR77
  publication-title: Curr. Protoc. Mol. Biol.
  doi: 10.1002/cpmb.115
  contributor:
    fullname: S Marillonnet
– volume: 6
  start-page: 343
  year: 2009
  ident: 32392_CR72
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1318
  contributor:
    fullname: DG Gibson
– volume: 14
  start-page: 29
  year: 2018
  ident: 32392_CR66
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2514
  contributor:
    fullname: F Villarreal
– volume: 16
  start-page: 688
  year: 2021
  ident: 32392_CR46
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/s41565-021-00878-4
  contributor:
    fullname: JL Terrell
– volume: 11
  start-page: 1
  year: 2020
  ident: 32392_CR29
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-15056-8
  contributor:
    fullname: A Miano
– volume: 112
  start-page: E1038
  year: 2015
  ident: 32392_CR67
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1416533112
  contributor:
    fullname: AY Weiße
– volume: 12
  start-page: 1
  year: 2021
  ident: 32392_CR42
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-25754-6
  contributor:
    fullname: S Kumar
– volume: 7
  start-page: 2665
  year: 2018
  ident: 32392_CR76
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.8b00333
  contributor:
    fullname: V Potapov
– volume: 10
  start-page: 659
  year: 2013
  ident: 32392_CR78
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2515
  contributor:
    fullname: YJ Chen
– volume: 12
  start-page: e1004685
  year: 2016
  ident: 32392_CR14
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1004685
  contributor:
    fullname: J Macia
– volume: 2
  start-page: 17083
  year: 2017
  ident: 32392_CR30
  publication-title: Nat. Microbiol.
  doi: 10.1038/nmicrobiol.2017.83
  contributor:
    fullname: SR Scott
– volume: 7
  year: 2016
  ident: 32392_CR41
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12546
  contributor:
    fullname: A Milias-Argeitis
– volume: 6
  start-page: 2157
  year: 2017
  ident: 32392_CR51
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.7b00169
  contributor:
    fullname: A Baumschlager
– volume: 13
  start-page: 353
  year: 2022
  ident: 32392_CR57
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2022.02.004
  contributor:
    fullname: D Benzinger
– volume: 33
  start-page: 377
  year: 2015
  ident: 32392_CR20
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3095
  contributor:
    fullname: K Zhou
– volume: 11
  start-page: 840
  year: 2015
  ident: 32392_CR65
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20156382
  contributor:
    fullname: J Izard
– volume: 10
  start-page: 2077
  year: 2016
  ident: 32392_CR26
  publication-title: ISME J.
  doi: 10.1038/ismej.2016.26
  contributor:
    fullname: SR Lindemann
– volume: 12
  year: 2021
  ident: 32392_CR35
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-22240-x
  contributor:
    fullname: AJ Fedorec
– volume: 4
  start-page: 1
  year: 2010
  ident: 32392_CR73
  publication-title: J. Biol. Eng.
  doi: 10.1186/1754-1611-4-10
  contributor:
    fullname: RS Cox
– volume: 37
  start-page: 181
  year: 2019
  ident: 32392_CR12
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2018.11.002
  contributor:
    fullname: NS McCarty
– volume: 6
  start-page: 1263
  year: 2017
  ident: 32392_CR69
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00361
  contributor:
    fullname: Y Qian
– volume: 63
  start-page: 109
  year: 2021
  ident: 32392_CR9
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2021.07.005
  contributor:
    fullname: W Liu
– volume: 112
  start-page: 8266
  year: 2015
  ident: 32392_CR24
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1506781112
  contributor:
    fullname: H Zhang
– volume: 6
  start-page: 800
  year: 2022
  ident: 32392_CR62
  publication-title: IEEE Control Syst. Lett.
  doi: 10.1109/LCSYS.2021.3086234
  contributor:
    fullname: D Fiore
– volume: 18
  start-page: 1
  year: 2019
  ident: 32392_CR18
  publication-title: Microbial Cell Factories
  doi: 10.1186/s12934-019-1083-3
  contributor:
    fullname: GW Roell
– volume: 12
  year: 2021
  ident: 32392_CR16
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-23336-0
  contributor:
    fullname: X Li
– volume: 13
  start-page: 1
  year: 2022
  ident: 32392_CR44
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31033-9
  contributor:
    fullname: F Bertaux
– volume: 330
  start-page: 1099
  year: 2010
  ident: 32392_CR47
  publication-title: Science
  doi: 10.1126/science.1192588
  contributor:
    fullname: M Scott
– ident: 32392_CR39
  doi: 10.1109/CDC40024.2019.9030209
– volume: 10
  start-page: 3290
  year: 2021
  ident: 32392_CR71
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.1c00131
  contributor:
    fullname: FN Santos-Navarro
– volume: 6
  start-page: 407
  year: 2010
  ident: 32392_CR6
  publication-title: Mol. Syst. Biol.
  doi: 10.1038/msb.2010.66
  contributor:
    fullname: EH Wintermute
– ident: 32392_CR60
  doi: 10.1101/2022.02.18.480836
– volume: 5
  start-page: 710
  year: 2016
  ident: 32392_CR68
  publication-title: ACS Synthetic Biol.
  doi: 10.1021/acssynbio.6b00040
  contributor:
    fullname: TE Gorochowski
– ident: 32392_CR59
  doi: 10.1101/2021.08.03.454926
– volume: 115
  start-page: 6506
  year: 2018
  ident: 32392_CR1
  publication-title: Proc. Natl Acad Sci. USA
  doi: 10.1073/pnas.1711842115
  contributor:
    fullname: YM Bar-On
– volume: 3
  start-page: 1
  year: 2020
  ident: 32392_CR8
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-020-01409-y
  contributor:
    fullname: B Borer
– volume: 365
  start-page: 1045
  year: 2019
  ident: 32392_CR63
  publication-title: Science
  doi: 10.1126/science.aaw0542
  contributor:
    fullname: MJ Liao
– volume: 13
  start-page: 926
  year: 2017
  ident: 32392_CR56
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20167456
  contributor:
    fullname: EJ Olson
– volume: 10
  start-page: 747
  year: 2014
  ident: 32392_CR54
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20145379
  contributor:
    fullname: M Scott
– volume: 29
  start-page: 1095
  year: 2021
  ident: 32392_CR27
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2021.04.001
  contributor:
    fullname: NE Grandel
– ident: 32392_CR55
SSID ssj0000391844
Score 2.56047
Snippet Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology...
Abstract Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic...
SourceID doaj
pubmedcentral
proquest
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Publisher
StartPage 4808
SubjectTerms 631/1647/2253
631/326/2565/855
631/553/1745
631/553/2695
631/553/552
Automation
Bacteria
Biology
Cell culture
Composition
Control systems
Dynamic models
E coli
Feedback
Humanities and Social Sciences
Labor
Microorganisms
multidisciplinary
Optimal control
Robust control
Science
Science (multidisciplinary)
Strains (organisms)
Synthetic biology
Time measurement
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4iCF7EJ1ZXieBNi7ZJmubok0XQk8J6CnkVRWjFrYL7650k3dUuiBevzaPJzCQzQ2a-QejQUEuo1mWqlOAppU6kpYdwzamxRpsCNIpPTr69K4YP9GbERj9KffmYsAgPHAl3YqjIrAcdqTKYN2fa2czmDoRFUUdcNI0y9sOZCncwEeC60C5L5pSUJ2Ma7oQQvJ6DUZBOepooAPb3rMz5GMm5h9Kgf65X0UpnOOKzuOA1tODqdbQUS0l-bqDHy1haHptPHRIqfXIi7gLRcVNhHWGZYQrTpBFvw2EfUN5FbeGPZ4Wb17aZjq1Ar8Ggl030cH11fzFMu7IJqaGUtyl1DozQqixIpnLOKldxZktNLQeNlQNPfKJVySqjiCiYE9oWgnlgdsbB18s42UKLdVO7bYQLrYliCryawlHjtACa51pxzT3Um7EJOpqSUL5GdAwZXrVJKSPBJRBcBoLLSYLOPZVnPT2ydfgA_JYdv-Vf_E7QYMoj2R23sfRJddwbR1mCDmbNcFD864eqXfMe-sD-wT2EPrzH296C-i3181OA3BZg2MDdlqDjqRR8__z3De_8x4Z30XLupdbD8BYDtNi-vbs9MIRavR9k_guk6Adn
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLfgEBIv08aH6HabgsQbRKNt0rRP0wYcExI8MWk8RfkqTEjtsbtN2v762Wl6UyfBa5M0iePYTmL_DPDWCV8Ka2tuTKO4EKHhNUG4FsJ5Z12FGoWCk799r07PxNdzeZ4u3FbJrXKUiVFQ-97RHfkhxU0p0n_50fIvp6xR9LqaUmg8hic5IeFRpPjiy-aOhdDPayFSrMyHsj5ciSgZogt7gaYBv53oowjbP7E1H3pKPngujVposQ1byXxkx8N678Cj0D2Hp0NCyZsX8PPTkGCeuRsbwyopRJEld3TWt8wO4Mz4C9fzAXUjMHIrT75b7PrCsH657se2LWo3bPTnJZwtPv_4eMpT8gTuhFBrLkJAU7StqzI3hZJtaJX0tRVeod4qcGUo3KqWrTNlU8nQWF81kuDZpcITX67KVzDr-i68BlZZWxpp8GxTBeGCbYwIhTXKKgJ8cz6DdyMJ9XLAyNDxbbus9UBwjQTXkeD6NoMTovKmJuFbxw_95S-dtot2osk9Qc20OXJTIW3wuS8Cigjsuwwmg_m4RjptupW-Z5EM3myKcbvQG4jpQn8V6-D88ZCIddRkbScDmpZ0F78j8HaD5g1KuAzej1xw3_m_J7z7_7HuwbOC-JFgdqs5zNaXV2EfDZ21PYjcfAeBVf4V
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3La9ZAEB9qRfBS6gujrazgTaNkH9nsQUp9lCLUkx_U07KvaFGS-vVr8etf78wmqaTUg9fsbpKdx84MO_MbgBdBRiG9b0rnjC6lTKZsCMKVyxCDDzVaFCpOPvpcHy7kp2N1vAFTu6ORgGc3hnbUT2qx_Pn696_1Hir826FkvHlzJrO657x0jva-vLwFt7kUkiT-aHT388ksDAY0cqyduXnpzD5lGP-Z73k9c_La9Wm2SgfbsDW6k2x_4P892EjdfbgzNJhcP4CvH4aG8yysfS6zpJJFNqans75lfgBrxleEvhxQOBKjNPMxl4tdnDjWn676aW2L1g4X_XgIi4OPX94flmMzhTJIqVelTAld07apReW4Vm1qtYqNl1GjHePIKSq_alQbnDC1SsbH2iiCa1caI8BKi0ew2fVdegys9l445TDWqZMMyRsnE_dOe00AcCEW8HIioT0dMDNsvusWjR0IbpHgNhPcXhbwjqh8NZPwrvODfvnNjupjgzRVJOiZtkLp4sqnWEWe8MjAb4vkCtiZeGQnGbJUaqfJZaoKeH41jOpDdyKuS_15noP7x6AR5-gZb2c_NB_pTr5nIG6D7g6eeAW8mqTg78f_veEn_zf9KdzlJJ8Ew1vvwOZqeZ520RFa-WdZuv8AmmQGLw
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwEB7RrZC4IFpADY_KlbhBVJL4kRxhKVpVKidWWk6WX1FRpQTBgrT8emac7FZZlUOvsR3H8_CMMzOfAU4c9wW3tkyNqVTKeajSkiBcc-68s06iRaHi5F83cjLlP2di1sPkUC3MIH5flN-feFTlmHOeoy1PXz_AR5HJc5LgsRyv_qcQ0nnJeV8X8--hA9sTIfoHfuV6VuRaaDRanOsd2O5dRXbR8fYTbITmM2x2l0cuduHuqrtMnrmFjSWUVI7I-tRz1tbMdkDM-ArXph3CRmCUQt7nabGXe8Pah3m7HFujJcNBf_Zgev3jdjxJ-4sSUse5mqc8BHQ761IWmcmVqEOthC8t9wptVI5coNKqUtTOFJUUobJeVoKg2IXC012min0YNW0TvgCT1hZGGDzHyMBdsJXhIbdGWUXgbs4ncLokoX7o8DB0jGMXpe4IrpHgOhJcvyZwSVRe9SQs6_gAWax71dCOV5knWJk6Q8nJhQ0-83nA7QDnLoJJ4GjJI90r2JOmMjpF7lCWwLdVM6oGxTtME9rn2AfXjwdC7KMGvB180LCluf8dQbYrdGVwN0vgbCkFfyd_f8EH_9f9ELZykk-C2JVHMJo_PodjdHLm9muU7jfbg_eV
  priority: 102
  providerName: Springer Nature
Title Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback
URI https://link.springer.com/article/10.1038/s41467-022-32392-z
https://www.proquest.com/docview/2702707411
https://search.proquest.com/docview/2703417161
https://pubmed.ncbi.nlm.nih.gov/PMC9381578
https://doaj.org/article/c491d0537f1c4d25bed1d2e006a4e3ea
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwED5tQ6C9IH6KwKiMxBtkJbEd249dWZkqdZqASeXJsh1nVLCk2jqk7a_n7CSDTOKFl0RKnNg5n3138XefAd46VlJmrUyNUSJlzKtUBgrXnLnSWVegRQnJyYvj4uiUzZd8uQW8z4WJoH1nV_v1z_P9evU9YivX527c48TGJ4upQjODmjbehm1B6V8hepx-qcKohXUJMh-oHF-yOB1E3HqO_kB6swsPKHrSwTgP7FGk7R_4mneRkneWS6MVmj2Ch537SCZtMx_Dlq-fwP12Q8nrp_DtY7vBPHHXNqZVhhRF0sHRSVMR25Iz4ytck7asG54EWHmH3SK_VoY0603TP1uhdcOHfjyD09nh1-lR2m2ekDrGxCZl3qMrWsmCZiYXvPKV4KW0rBRot3LsmZBuJXnlDFUF98qWheKBnp0LjPgyQZ_DTt3U_gWQwlpquMHYpvDMeasM87k1wopA-ObKBN71ItTrliNDx7VtKnUre42y11H2-iaBgyDl25KB3zpeaC7OdNfL2jGVlYFqpspQm3JufZmVuccpAuum3iSw1_eR7gbdpQ6pdSK4SFkCb25v43AJayCm9s1VLIPfj0EilhGDvh00aHgH9TASb3d6l8D7Xgv-VP7vD3753xW9gl30z1QAiWdqD3Y2F1f-NfpAGztCzV8KPMrZpxHcm0zmX-Z4Pjg8PvmMV6fFdBT_LuBxweQojpDf9SAO9A
link.rule.ids 230,315,733,786,790,870,891,2115,12083,12792,21416,24346,27955,27956,31752,31753,33406,33407,33777,33778,41153,42222,43343,43633,43838,51609,53825,53827,74100,74390,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLfgJgQvE59a2RhF4g2i0TZp2ifEvnTAdkJok8ZTlK_ChNQeuxvS9tdjp-lNnTRem6RJHMd2EvtngLeWu4IbUzGta8k49zWrCMI159ZZY0vUKBScfDwrp6f8y5k4ixdui-hWOcjEIKhdZ-mOfIfipiTpv-zj_A-jrFH0uhpTaNyHNYLcrCawtnsw-_Z9dctC-OcV5zFa5kNR7Sx4kA3BiT1H44BdjzRSAO4fWZu3fSVvPZgGPXT4GNajAZl-6lf8Cdzz7VN40KeUvHoGP_b7FPOpvTIhsJKCFNPokJ52TWp6eGb8he1Yj7vhU3Isj95b6d9znXbzZTe0bVC_YaPfz-H08OBkb8pi-gRmOZdLxr1HY7SpyiLTuRSNb6RwleFOoubKcW0o4KoSjdVFXQpfG1fWggDahcQzXyaLFzBpu9ZvQFoaU2ih8XRTem69qTX3udHSSIJ8sy6BdwMJ1bxHyVDhdbuoVE9whQRXgeDqOoFdovKqJiFchw_dxU8VN4yyvM4cgc00GfJTLox3mcs9Cgnsu_A6ga1hjVTcdgt1wyQJvFkV44ahVxDd-u4y1MH54zER68jR2o4GNC5pz38F6O0aDRyUcQm8H7jgpvO7J_zy_2N9DQ-nJ8dH6ujz7OsmPMqJNwl0t9yCyfLi0r9Cs2dptiNv_wPsgQJ7
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BEaiXiqcIFDASN7CWJE7snBBQlvKqOFCpnCy_QqtKyba7rdT-emYcZ6tUgmtsx_Z4PDO2Z74BeOWEL4W1ihvTSC5EaLgiCNdCOO-sq1GjUHDyj716d198PagOkv_TMrlVjjIxCmrfO7ojn1HclCT9l8_a5Bbxc2f-bnHCKYMUvbSmdBo34RYZ2ZTGQc0_r-9bCAldCZHiZt6WarYUUUpEd_YCzQR-OdFNEcJ_Ynde95q89nQaNdL8LmwlU5K9H9b-HtwI3X24PSSXvHgAv3eGZPPMXdgYYknhiiy5prO-ZXYAasZfuJ4PCByBkYt58uNi50eG9YtVP7ZtUdNho-OHsD__9OvjLk-JFLgTQq64CAHN0lbVZW4KWbWhlZVXVniJOqzAVaLQK1W1zpRNXYXG-rqpCKq9knj6y2X5CDa6vguPgdXWlqYyeM6pg3DBNkaEwhppJYG_OZ_B65GEejHgZej4zl0qPRBcI8F1JLi-zOADUXldk7Cu44f-9I9OW0c70eSeYGfaHDmrqGzwuS8Cigvsuwwmg-1xjXTagEt9xS4ZvFwX49ah9xDThf4s1sH544ER68jJ2k4GNC3pjg4jCHeDpg5KuwzejFxw1fm_J_zk_2N9AXeQqfX3L3vfnsJmQaxJ6Lv1NmysTs_CM7R_VvZ5ZOy_g00FQQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dynamic+cybergenetic+control+of+bacterial+co-culture+composition+via+optogenetic+feedback&rft.jtitle=Nature+communications&rft.au=Guti%C3%A9rrez+Mena%2C+Joaqu%C3%ADn&rft.au=Kumar%2C+Sant&rft.au=Khammash%2C+Mustafa&rft.date=2022-08-16&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-022-32392-z&rft.externalDocID=10_1038_s41467_022_32392_z
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon