Molecular evolution of protein-RNA mimicry as a mechanism for translational control

• Published in: Nucleic acids research Vol. 42; no. 5; pp. 3261 - 3271
• Main Authors: Katz, Assaf, Solden, Lindsey, Zou, S Betty, Navarre, William Wiley, Ibba, Michael
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2014
• Subjects: Aspartate-tRNA Ligase - chemistry; Aspartate-tRNA Ligase - metabolism; Binding Sites; Catalytic Domain; Evolution, Molecular; Lysine-tRNA Ligase - chemistry; Models, Molecular; Molecular Mimicry; Nucleic Acid Enzymes; Peptide Elongation Factors - chemistry; Peptide Elongation Factors - metabolism; Protein Binding; Protein Biosynthesis; Ribosomes - metabolism; RNA, Transfer - chemistry; RNA, Transfer - metabolism; Transfer RNA Aminoacylation

Elongation factor P (EF-P) is a conserved ribosome-binding protein that structurally mimics tRNA to enable the synthesis of peptides containing motifs that otherwise would induce translational stalling, including polyproline. In many bacteria, EF-P function requires post-translational modification w...