Myeloma Cells Are Highly Sensitive to the Granule Exocytosis Pathway Mediated by WT1-Specific Cytotoxic T Lymphocytes - Azuma, Taichi; Otsuki, Takemi; Kuzushima, Kiyotaka; Froelich, Christopher J.; Fujita, Shigeru; Yasukawa, Masaki (Clinical cancer research, 2004)
Keywords: Antigens, Neoplasm - chemistry; Antineoplastic agents; Biological and medical sciences; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Calcium - metabolism; Cell Line; Cell Line, Tumor; Chromium - metabolism; Cytoplasmic Granules - metabolism; Cytoplasmic Granules - physiology; Dose-Response Relationship, Drug; Egtazic Acid - pharmacology; Enzyme-Linked Immunosorbent Assay; Exocytosis; Flow Cytometry; Genes, MHC Class I; Humans; Immunotherapy; Interferon-gamma - metabolism; Lymphoma - metabolism; Macrolides - pharmacology; Medical sciences; Membrane Glycoproteins - metabolism; Multiple Myeloma - metabolism; Peptides - chemistry; Perforin; Pharmacology. Drug treatments; Pore Forming Cytotoxic Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; T-Lymphocytes, Cytotoxic - metabolism; Treatment Outcome; Tumors; WT1 Proteins - biosynthesis; Signal transduction; Immunoglobulinopathy; Lymphoproliferative syndrome; Wilms tumor suppressor gene 1; Malignant hemopathy; Granule; Exocytosis; Myeloma; In vitro; Cytotoxic T lymphocyte; Tumor suppressor gene