Transient Hyperglycemia Affects the Extent of Ischemia-Reperfusion-induced Renal Injury in Rats

• Published in: Anesthesiology (Philadelphia) Vol. 108; no. 3; pp. 402 - 414
• Main Authors: HIROSE, Ryutaro, FENGYUN XU, DANG, Kim, TAO LIU, BEHRENDS, Matthias, BRAKEMAN, Paul R, WIENER-KRONISH, Jeanine, NIEMANN, Claus U
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.03.2008
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Hyperglycemia - blood; Hyperglycemia - complications; Hyperglycemia - pathology; Kidney - blood supply; Kidney - pathology; Male; Medical sciences; Rats; Rats, Inbred Lew; Reperfusion Injury - blood; Reperfusion Injury - etiology; Reperfusion Injury - pathology; Kidney disease; Vertebrata; Hyperglycemia; Mammalia; Urinary system disease; Rat; Animal; Rodentia; Cardiovascular disease; Anesthesia; Renal ischemia reperfusion injury

Chronic hyperglycemia is known to increase renal injury, particularly during ischemia-reperfusion episodes. The goal of this study was to examine whether transient hyperglycemia during or after renal ischemia-reperfusion increased renal dysfunction. Male Lewis rats underwent sham operations or unila...