The prognostic impact of Wilms tumor-1 polymorphism (rs16754) and human myeloid inhibitory C-type lectin-like receptor expression in cytogenetically normal-acute myeloid leukemia

• Published in: Egyptian Journal of Medical Human Genetics Vol. 22; no. 1; pp. 64 - 12
• Main Authors: Bedair, Hanan M., Attia, Mohamed H., Gohar, Suzy F., Khalaf, Fatma M., Badr El-DIN, Sahar, Rabie, Hatem
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 12.07.2021; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Acute leukemia; Acute myeloid leukemia; Cytogenetic; Cytogenetics; Ethylenediaminetetraacetic acid; Flow cytometry; Gene mutations; Gene polymorphism; Genes; Genetic aspects; Genotypes; Genotyping; Lectins; Leukemia; Medicine; Medicine & Public Health; Mutants; Mutation; Myeloid neoplasm; Polymerase chain reaction; Polymorphism; Prognosis; Remission; Remission (Medicine); Single nucleotide polymorphisms; Single-nucleotide polymorphism; Survival; Tumors; Wilms’ tumor; Egypt; Acute leukemia; Prognosis; Wilms’ tumor; Myeloid neoplasm; Genotypes; Cytogenetic

Background There are several genetic mutations that carry prognostic and predictive values in acute myeloid leukemia (AML). They are also implicated in disease pathogenesis and patient outcome. They can be a target of novel therapies for AML. The aim of the current study was to investigate prognosti...