Social stress in tree shrews as an animal model of depression: an example of a behavioral model of a CNS disorder

• Published in: CNS spectrums Vol. 10; no. 3; p. 182
• Main Author: Fuchs, Eberhard
• Format: Journal Article
• Language: English
• Published: United States 01.03.2005
• Subjects: Animals; Antidepressive Agents - therapeutic use; Arousal - physiology; Dentate Gyrus - physiopathology; Depressive Disorder - drug therapy; Depressive Disorder - physiopathology; Depressive Disorder - psychology; Disease Models, Animal; Dominance-Subordination; Hippocampus - physiopathology; Humans; Hydrocortisone - urine; Male; Receptors, Neurotransmitter - physiology; Stress, Psychological - complications; Tupaiidae - psychology

Animal models are invaluable in preclinical research on human psychopathology. Valid animal models to study the pathophysiology of depression and specific biological and behavioral responses to antidepressant drug treatments are of prime interest. In order to improve our knowledge of the causal mech...