Cell-size-dependent upregulation of HGF expression in dermal fibroblasts: Impact on human skin connective tissue aging

• Published in: Journal of dermatological science Vol. 88; no. 3; pp. 289 - 297
• Main Authors: Qin, Zhaoping, Worthen, Christal A., Quan, Taihao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017
• Subjects: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; c-Jun; Cell Size; Cells, Cultured; Collagen - metabolism; Connective Tissue - physiology; Dermis - cytology; Dermis - metabolism; Dermis - secretion; Fibroblasts - metabolism; Fibroblasts - secretion; Hepatocyte Growth Factor - metabolism; Hepatocyte Growth Factor - secretion; HGF; Humans; Laser Capture Microdissection; Primary Cell Culture; Proto-Oncogene Proteins c-jun - metabolism; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; Signal Transduction - physiology; Skin aging; Skin Aging - drug effects; Skin Aging - physiology; TGF-β; Transforming Growth Factor beta - metabolism; Up-Regulation; Vitamin A - pharmacology; Young Adult; c-Jun; HGF; MMPs; LCM; TGF-β; Cell size; Skin aging; ECM

•As HGF suppresses collagen production, its role in human connective tissue aging is unknown.•HGF is significantly elevated in aged human skin dermis in vivo.•Reduced fibroblast size, which is a prominent feature of aged skin fibroblasts in vivo, is responsible for elevated HGF expression.•Cell-size...