Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial

• Published in: The Lancet (British edition) Vol. 402; no. 10396; pp. 105 - 117
• Main Authors: Collins, Michael G, Fahim, Magid A, Pascoe, Elaine M, Hawley, Carmel M, Johnson, David W, Varghese, Julie, Hickey, Laura E, Clayton, Philip A, Dansie, Kathryn B, McConnochie, Rachael C, Vergara, Liza A, Kiriwandeniya, Charani, Reidlinger, Donna, Mount, Peter F, Weinberg, Laurence, McArthur, Colin J, Coates, P Toby, Endre, Zoltan H, Goodman, David, Howard, Kirsten, Howell, Martin, Jamboti, Jagadish S, Kanellis, John, Laurence, Jerome M, Lim, Wai H, McTaggart, Steven J, O'Connell, Philip J, Pilmore, Helen L, Wong, Germaine, Chadban, Steven J, Ying, Tracey, Gracey, David, Aouad, Leyla, Wyburn, Kate, Habijanec, Beatriz, Yeo, Hee-eun (Ellen), Lin, Lin, Rosales, Brenda, Hudaly, Julia, Rodrigues, Vera, O'Connell, Philip, Murie, Penelope, Endre, Zoltan, Gray, Zuzana, Spicer, Rebecca, Durkan, Anne, Jegatheesan, Dev, Leary, Diana, Guo, Yujing (Sarah), Coburn, Amanda, Irvine, Rachael, McTaggart, Steven, Crawford, Aimee, Hockley, Bronwyn, Fischer, Karen, Mount, Peter, Baulch, Sarah, Claxton, Gayle, Harris, Saskia, Sidiropoulos, Sofia, Veenendal, Marieke, Barbis, Rita, Brahmbhatt, Anjalee, Le Page, Amelia, Jamboti, Jagadish, Chiam, Anna, Warger, Anne, Collins, Michael, Pilmore, Helen, Dittmer, Ian, Manley, Paul, Ahmed, Jafar, McConnochie, Rachael, Newby, Lynette, Chen, Yan, Simmonds, Catherine, Irvine, John, Usher, Jenny, Clark, Carolyn, Beckett, Claire, Prestidge, Chanel, Erickson, Robin, Rea, Miriam, Scherring, Claire
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 08.07.2023; Elsevier Limited
• Subjects: Acidosis; Adaptive algorithms; Adult; Australia - epidemiology; Brain death; Child; Chloride; Chlorides; Clinical medicine; Clinical trials; Creatinine; Crystalloid Solutions; Dialysis; Double-Blind Method; Double-blind studies; Female; Fluids; Hemodialysis; Humans; Hyperkalemia; Intravenous administration; Intravenous therapy; Kidney Transplantation; Kidney transplants; Male; Medical records; Medical research; Metabolism; Optimization; Patients; Plasma; Potassium; Risk; Safety; Sodium; Sodium chloride; Surgery; Systematic review; Australia; New Zealand

Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a transplant to maintain intravascular volume and optimise graft function. Saline (0·9% sodium chloride) is widely used but might increa...