PI3Kβ controls immune evasion in PTEN-deficient breast tumours

• Published in: Nature (London) Vol. 617; no. 7959; pp. 139 - 146
• Main Authors: Bergholz, Johann S., Wang, Qiwei, Wang, Qi, Ramseier, Michelle, Prakadan, Sanjay, Wang, Weihua, Fang, Rong, Kabraji, Sheheryar, Zhou, Qian, Gray, G. Kenneth, Abell-Hart, Kayley, Xie, Shaozhen, Guo, Xiaocan, Gu, Hao, Von, Thanh, Jiang, Tao, Tang, Shuang, Freeman, Gordon J., Kim, Hye-Jung, Shalek, Alex K., Roberts, Thomas M., Zhao, Jean J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.05.2023
• Subjects: 13; 38; 631/67/1347; 631/67/395; 631/67/580; 64/60; 96; Animals; Humanities and Social Sciences; Immune Evasion; Immunotherapy; Mammary Neoplasms, Animal - enzymology; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - immunology; Mammary Neoplasms, Experimental - enzymology; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - immunology; Mice; multidisciplinary; Phosphatidylinositol 3-Kinase - metabolism; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase - deficiency; PTEN Phosphohydrolase - genetics; Science; Science (multidisciplinary); Signal Transduction

Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across all cancer types 1 . PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform has been shown to play an important role in PTEN-deficient tumours, but the mechanisms underlying the importance of PI...