Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

• Published in: European heart journal Vol. 42; no. 42; pp. 4373 - 4385
• Main Authors: Cui, Hongtu, Chen, Yanghui, Li, Ke, Zhan, Rui, Zhao, Mingming, Xu, Yangkai, Lin, Zhiyong, Fu, Yi, He, Qihua, Tang, Paul C, Lei, Ienglam, Zhang, Jifeng, Li, Chenze, Sun, Yang, Zhang, Xinhua, Horng, Tiffany, Lu, Hong S, Chen, Y Eugene, Daugherty, Alan, Wang, Daowen, Zheng, Lemin
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 07.11.2021
• Subjects: Animals; Aortic Aneurysm; Biomarkers; Dissection; Humans; Metabolomics; Mice; Succinic Acid; Aortic aneurysm and dissection; Oxoglutarate dehydrogenase; Succinate; Macrophage

Abstract Aims Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes in macrophages, we investigated the significance of succinate in the pathogenesis...