Self-potentiation of Ligand-Toxin Conjugates Containing Ricin A Chain Fused with Viral Structures (∗)
A chimeric protein was obtained by fusing together the ricin toxin A chain (RTA) gene and a DNA fragment encoding the N terminus of protein G of the vesicular stomatitis virus. Chimeric RTA (cRTA) retained full enzymic activity in a cell-free assay, but was 10-fold less toxic against human leukemic...
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Published in | The Journal of biological chemistry Vol. 270; no. 40; pp. 23345 - 23351 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
06.10.1995
American Society for Biochemistry and Molecular Biology |
Subjects | |
Online Access | Get full text |
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