A Mutant Yeast Topoisomerase II (top2G437S) with Differential Sensitivity to Anticancer Drugs in the Presence and Absence of ATP

To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant type II topoisomerase that conferred cellular resistance to CP-115,953, amsacrine, etoposide, and ellipticine. The mutant enzyme contained a...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 273; no. 44; pp. 29086 - 29092
Main Authors Sabourin, Michelle, Byl, Jo Ann Wilson, Hannah, S. Erin, Nitiss, John L., Osheroff, Neil
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 30.10.1998
American Society for Biochemistry and Molecular Biology
Subjects
Adenosine Triphosphate - pharmacology
Antineoplastic Agents - pharmacology
DNA Topoisomerases, Type II - chemistry
DNA Topoisomerases, Type II - drug effects
DNA Topoisomerases, Type II - genetics
Drug Resistance, Neoplasm
Enzyme Stability
Glycine - genetics
Mutagenesis
Saccharomyces cerevisiae
Saccharomyces cerevisiae - enzymology
Serine - genetics
Online AccessGet full text

Cover

Abstract To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant type II topoisomerase that conferred cellular resistance to CP-115,953, amsacrine, etoposide, and ellipticine. The mutant enzyme contained a single point mutation that converted Gly437 → Ser (top2G437S). Purified top2G437S displayed wild-type enzymatic activity in the absence of drugs but exhibited two properties that were not predicted by the cellular resistance phenotype. First, in the absence of ATP, it was hypersensitive to all of the drugs examined and hypersensitivity correlated with increased drug affinity. Second, in the presence of ATP, top2G437S lost its hypersensitivity and displayed wild-type drug sensitivity. Since the resistance of yeast harboring top2G437S could not be explained by alterations in enzyme-drug interactions, physiological levels of topoisomerase II were determined. The Gly437 → Ser mutation reduced the stability of topoisomerase II and decreased the cellular concentration of the enzyme. These findings suggest that the physiological drug resistance phenotype conferred by top2G437S results primarily from its decreased stability. This study highlights the need to analyze both the biochemistry and the physiology of topoisomerase II mutants with altered drug sensitivity in order to define the mechanistic bridge that links enzyme function to cellular phenotype.
AbstractList To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant type II topoisomerase that conferred cellular resistance to CP-115,953, amsacrine, etoposide, and ellipticine. The mutant enzyme contained a single point mutation that converted Gly437 → Ser (top2G437S). Purified top2G437S displayed wild-type enzymatic activity in the absence of drugs but exhibited two properties that were not predicted by the cellular resistance phenotype. First, in the absence of ATP, it was hypersensitive to all of the drugs examined and hypersensitivity correlated with increased drug affinity. Second, in the presence of ATP, top2G437S lost its hypersensitivity and displayed wild-type drug sensitivity. Since the resistance of yeast harboring top2G437S could not be explained by alterations in enzyme-drug interactions, physiological levels of topoisomerase II were determined. The Gly437 → Ser mutation reduced the stability of topoisomerase II and decreased the cellular concentration of the enzyme. These findings suggest that the physiological drug resistance phenotype conferred by top2G437S results primarily from its decreased stability. This study highlights the need to analyze both the biochemistry and the physiology of topoisomerase II mutants with altered drug sensitivity in order to define the mechanistic bridge that links enzyme function to cellular phenotype.
To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant type II topoisomerase that conferred cellular resistance to CP-115,953, amsacrine, etoposide, and ellipticine. The mutant enzyme contained a single point mutation that converted Gly super(437) arrow right Ser (top2G437S). Purified top2G437S displayed wild-type enzymatic activity in the absence of drugs but exhibited two properties that were not predicted by the cellular resistance phenotype. First, in the absence of ATP, it was hypersensitive to all of the drugs examined and hypersensitivity correlated with increased drug affinity. Second, in the presence of ATP, top2G437S lost its hypersensitivity and displayed wild-type drug sensitivity. Since the resistance of yeast harboring top2G437S could not be explained by alterations in enzyme-drug interactions physiological levels of topoisomerase II were determined. The Gly super(437) arrow right Ser mutation reduced the stability of topoisomerase II and decreased the cellular concentration of the enzyme. These findings suggest that the physiological drug resistance phenotype conferred by top2G437S results primarily from its decreased stability. This study highlights the need to analyze both the biochemistry and the physiology of topoisomerase II mutants with altered drug sensitivity in order to define the mechanistic bridge that links enzyme function to cellular phenotype.
To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant type II topoisomerase that conferred cellular resistance to CP-115,953, amsacrine, etoposide, and ellipticine. The mutant enzyme contained a single point mutation that converted Gly437 --> Ser (top2G437S). Purified top2G437S displayed wild-type enzymatic activity in the absence of drugs but exhibited two properties that were not predicted by the cellular resistance phenotype. First, in the absence of ATP, it was hypersensitive to all of the drugs examined and hypersensitivity correlated with increased drug affinity. Second, in the presence of ATP, top2G437S lost its hypersensitivity and displayed wild-type drug sensitivity. Since the resistance of yeast harboring top2G437S could not be explained by alterations in enzyme-drug interactions, physiological levels of topoisomerase II were determined. The Gly437 --> Ser mutation reduced the stability of topoisomerase II and decreased the cellular concentration of the enzyme. These findings suggest that the physiological drug resistance phenotype conferred by top2G437S results primarily from its decreased stability. This study highlights the need to analyze both the biochemistry and the physiology of topoisomerase II mutants with altered drug sensitivity in order to define the mechanistic bridge that links enzyme function to cellular phenotype.
To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant type II topoisomerase that conferred cellular resistance to CP-115,953, amsacrine, etoposide, and ellipticine. The mutant enzyme contained a single point mutation that converted Gly 437 → Ser (top2G437S). Purified top2G437S displayed wild-type enzymatic activity in the absence of drugs but exhibited two properties that were not predicted by the cellular resistance phenotype. First, in the absence of ATP, it was hypersensitive to all of the drugs examined and hypersensitivity correlated with increased drug affinity. Second, in the presence of ATP, top2G437S lost its hypersensitivity and displayed wild-type drug sensitivity. Since the resistance of yeast harboring top2G437S could not be explained by alterations in enzyme-drug interactions, physiological levels of topoisomerase II were determined. The Gly 437 → Ser mutation reduced the stability of topoisomerase II and decreased the cellular concentration of the enzyme. These findings suggest that the physiological drug resistance phenotype conferred by top2G437S results primarily from its decreased stability. This study highlights the need to analyze both the biochemistry and the physiology of topoisomerase II mutants with altered drug sensitivity in order to define the mechanistic bridge that links enzyme function to cellular phenotype.
Author Nitiss, John L.
Sabourin, Michelle
Byl, Jo Ann Wilson
Hannah, S. Erin
Osheroff, Neil
Author_xml – sequence: 1
  givenname: Michelle
  surname: Sabourin
  fullname: Sabourin, Michelle
  organization: Department of Biochemistry, Nashville, Tennessee 37232-0146
– sequence: 2
  givenname: Jo Ann Wilson
  surname: Byl
  fullname: Byl, Jo Ann Wilson
  organization: Department of Biochemistry, Nashville, Tennessee 37232-0146
– sequence: 3
  givenname: S. Erin
  surname: Hannah
  fullname: Hannah, S. Erin
  organization: Department of Biochemistry, Nashville, Tennessee 37232-0146
– sequence: 4
  givenname: John L.
  surname: Nitiss
  fullname: Nitiss, John L.
  organization: Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101
– sequence: 5
  givenname: Neil
  surname: Osheroff
  fullname: Osheroff, Neil
  email: osheron@ctrvax.vanderbilt.edu
  organization: Department of Biochemistry, Nashville, Tennessee 37232-0146
BackLink https://www.ncbi.nlm.nih.gov/pubmed/9786915$$D View this record in MEDLINE/PubMed
BookMark eNp1kM1r3DAQxUVJSTdp770UdCghPXirL6_s3kzSpgspDWQL7UlI8jhWWFtbSU7IrX96lXrJIdC5zDDz3mP4HaGD0Y-A0FtKlpRI8fHW2CWTfCnEktWkWr1AC0oqXvCS_jxAC0IYLWpWVq_QUYy3JJeo6SE6rGW1qmm5QH8a_G1Kekz4F-iY8MbvvIt-gKAj4PUanya_YxeCy-sP-N6lHp-7roMAY3J6i69hjC65O5cecPK4yVurRwsBn4fpJmI34tQDvgoQIa-xHlvcmHn2HW42V6_Ry05vI7zZ92P048vnzdnX4vL7xfqsuSysEDIVjLeSSWp4DaUBXRloKQWoCVsZakDUJbGypBa6VjNKDDG8K0lHQXPBYNXyY3Qy5-6C_z1BTGpw0cJ2q0fwU1RUkppJybOQzEIbfIwBOrULbtDhQVGiHqGrDF1l6EoI9Q96trzbZ09mgPbJsKec7-_ne-9u-nsXQBnnbQ_D85hPswwyhzsHQUXrHlG12WKTar37_w9_Af56nqM
CitedBy_id crossref_primary_10_1021_bi010681q
crossref_primary_10_1016_S0378_1119_01_00554_6
crossref_primary_10_1016_j_pep_2010_08_001
crossref_primary_10_1021_bi0021838
crossref_primary_10_1128_AAC_44_12_3344_3350_2000
crossref_primary_10_3390_molecules27227768
crossref_primary_10_1074_jbc_275_11_7980
crossref_primary_10_1074_jbc_M804058200
Cites_doi 10.1073/pnas.85.20.7501
10.1016/0959-8049(96)00056-1
10.1146/annurev.pa.34.040194.001203
10.1021/bi00441a005
10.1128/jb.140.2.424-435.1979
10.1023/A:1026431524236
10.1074/jbc.270.37.21429
10.1111/j.1749-6632.1996.tb26374.x
10.1073/pnas.88.17.7654
10.1007/BF01757348
10.1007/BF00340712
10.2165/00003495-199549010-00002
10.1016/S0021-9258(19)84722-1
10.1021/bi00221a012
10.1038/bjc.1995.177
10.1038/42294
10.1074/jbc.270.4.1913
10.1007/BF00685611
10.1016/S0021-9258(18)42185-0
10.1073/pnas.88.23.10485
10.1042/bj3030681
10.1021/bi00462a012
10.1002/(SICI)1098-1128(199707)17:4<367::AID-MED3>3.0.CO;2-U
10.1016/S0959-440X(96)80099-6
10.3727/095535489820875309
10.1016/0300-9084(95)90009-8
10.1124/mol.52.4.658
10.1002/path.1711750103
10.1016/S0021-9258(18)83757-7
10.1002/em.2850240402
10.1021/tx00035a001
10.1002/bies.950130603
10.1016/0014-4827(92)90190-J
10.1016/S0021-9258(18)53976-4
10.1016/0092-8674(92)90558-T
10.1016/0921-8777(90)90064-C
10.1021/bi00388a018
10.1007/BF00685084
10.1021/bi00439a051
10.3109/10428199409051674
10.1007/s002800050751
10.1016/S0021-9258(17)44700-4
10.1038/379225a0
10.1016/S1054-3589(08)61135-7
10.1016/S0021-9258(18)67607-0
10.1074/jbc.271.46.29238
10.1146/annurev.bi.65.070196.003223
10.1074/jbc.270.35.20359
10.1007/BF00684857
10.1111/j.1365-2141.1993.tb03162.x
10.1097/00001813-199710000-00001
10.1016/S0021-9258(17)46668-3
10.3109/07357909409021413
10.1073/pnas.74.12.5463
10.1074/jbc.272.49.31190
10.1016/0076-6879(91)94024-7
ContentType Journal Article
Copyright 1998 © 1998 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
Copyright_xml – notice: 1998 © 1998 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
DBID 6I.
AAFTH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7TM
M7N
DOI 10.1074/jbc.273.44.29086
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Nucleic Acids Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Algology Mycology and Protozoology Abstracts (Microbiology C)
Nucleic Acids Abstracts
DatabaseTitleList
Algology Mycology and Protozoology Abstracts (Microbiology C)
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
EISSN 1083-351X
EndPage 29092
ExternalDocumentID 10_1074_jbc_273_44_29086
9786915
273_44_29086
S0021925819594959
Genre Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S
Journal Article
GrantInformation_xml – fundername: NIGMS NIH HHS
  grantid: GM33944
– fundername: NCI NIH HHS
  grantid: CA52814
– fundername: NCI NIH HHS
  grantid: CA21765
GroupedDBID ---
-DZ
-ET
-~X
.55
.GJ
0SF
186
18M
2WC
3O-
53G
5BI
5GY
5RE
5VS
6I.
6TJ
79B
85S
AAEDW
AAFTH
AAFWJ
AARDX
AAXUO
AAYOK
ABDNZ
ABOCM
ABPPZ
ABRJW
ABTAH
ACGFO
ACNCT
ADBBV
ADIYS
AENEX
AEXQZ
AFFNX
AFMIJ
AFOSN
AFPKN
AHPSJ
AI.
ALMA_UNASSIGNED_HOLDINGS
BTFSW
C1A
CJ0
CS3
DIK
DU5
E3Z
EBS
EJD
F20
F5P
FA8
FDB
FRP
GROUPED_DOAJ
GX1
HH5
IH2
KQ8
L7B
MVM
N9A
NHB
OHT
OK1
P-O
P0W
P2P
R.V
RHF
RHI
RNS
ROL
RPM
SJN
TBC
TN5
TR2
UHB
UPT
UQL
VH1
VQA
W8F
WH7
WHG
WOQ
X7M
XFK
XSW
Y6R
YQT
YSK
YWH
YYP
YZZ
ZA5
ZGI
ZY4
~02
~KM
-
02
08R
55
AAWZA
ABFLS
ABPTK
ABUFD
ABZEH
ACDCL
ADACO
ADBIT
ADCOW
AEILP
AIZTS
DL
DZ
ET
FH7
GJ
H13
KM
LI
MYA
O0-
OHM
X
XHC
0R~
AALRI
ADVLN
AITUG
AKRWK
AMRAJ
CGR
CUY
CVF
ECM
EIF
NPM
29J
34G
39C
4.4
41~
AAYJJ
AAYXX
ABFSI
ACSFO
ACYGS
ADNWM
AOIJS
BAWUL
CITATION
E.L
HYE
J5H
QZG
UKR
XJT
ZE2
7TM
M7N
ID FETCH-LOGICAL-c447t-23d7271b39e5bea8bed11ee9026b1be4950c751cefda210b0b3f50f1ea342e6d3
ISSN 0021-9258
IngestDate Fri Oct 25 07:16:33 EDT 2024
Fri Aug 23 02:59:35 EDT 2024
Sat Sep 28 08:30:12 EDT 2024
Tue Jan 05 15:25:45 EST 2021
Fri Feb 23 02:45:16 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 44
Language English
License This is an open access article under the CC BY license.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c447t-23d7271b39e5bea8bed11ee9026b1be4950c751cefda210b0b3f50f1ea342e6d3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
OpenAccessLink https://dx.doi.org/10.1074/jbc.273.44.29086
PMID 9786915
PQID 17092773
PQPubID 23462
PageCount 7
ParticipantIDs proquest_miscellaneous_17092773
crossref_primary_10_1074_jbc_273_44_29086
pubmed_primary_9786915
highwire_biochem_273_44_29086
elsevier_sciencedirect_doi_10_1074_jbc_273_44_29086
ProviderPackageCode RHF
RHI
PublicationCentury 1900
PublicationDate 1998-10-30
PublicationDateYYYYMMDD 1998-10-30
PublicationDate_xml – month: 10
  year: 1998
  text: 1998-10-30
  day: 30
PublicationDecade 1990
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The Journal of biological chemistry
PublicationTitleAlternate J Biol Chem
PublicationYear 1998
Publisher Elsevier Inc
American Society for Biochemistry and Molecular Biology
Publisher_xml – name: Elsevier Inc
– name: American Society for Biochemistry and Molecular Biology
References Negri, Bernardi, Donzelli, Scovassi (bib21) 1995; 77
Osheroff (bib68) 1986; 261
D'Arpa (bib36) 1994; 29
Wang (bib13) 1996; 65
Walker, Smith, Youdale, Leblanc, Whitfield, Sikorska (bib17) 1991; 51
Chan, Ng, Eder, Schnipper (bib48) 1993; 268
Robinson, Osheroff (bib71) 1989; 29
Harrison (bib39) 1995; 175
Worland, Wang (bib59) 1989; 264
Wasserman, Wang (bib53) 1994; 54
Nitiss, Liu, Harbury, Jannatipour, Wasserman, Wang (bib28) 1992; 52
Liu, L. (ed) (1994)
Ferguson, Baguley (bib14) 1994; 24
Osheroff, Shelton, Brutlag (bib65) 1983; 258
Davies, Davies, Hall, Hickson (bib27) 1990; 235
Hasegawa, Abe, Naito, Kotoh, Kumazawa, Hipfner, Deeley, Cole, Kuwano (bib40) 1995; 71
Nitiss, Wang (bib61) 1988; 85
Smith, Rackstraw, Cotter (bib19) 1994; 69
Zwelling, Hinds, Chan, Mayes, Sie, Parker, Silberman, Radcliffe, Beran, Blick (bib44) 1989; 264
Pommier, Fesen, Goldwasser (bib6) 1996
Alton, Harris (bib33) 1993; 85
Bugg, Danks, Beck, Suttle (bib46) 1991; 88
Strathern, Higgins (bib62) 1991; 194
Malonne, Atassi (bib42) 1997; 8
Schiestl, Gietz (bib58) 1989; 16
McPherson, Deffie, Jones, Brown, Deuchars, Goldenberg (bib29) 1997; 17
Froelich-Ammon, Osheroff (bib5) 1995; 270
Nitiss, Beck (bib7) 1996; 32a
Sinha (bib26) 1995; 49
Sambrook, Fritsch, Maniatis (bib57) 1989
Sanger, Nicklen, Coulson (bib63) 1977; 74
Elsea, Hsiung, Nitiss, Osheroff (bib54) 1995; 270
Tartof, Hobbs (bib60) 1987; 9
Corbett, Osheroff (bib2) 1993; 6
Chen, Liu (bib3) 1994; 34
Pommier (bib1) 1993; 32
Liu, Hsiung, Jannatipour, Yeh, Nitiss (bib49) 1994; 54
(bib25) 1991
Sullivan, Latham, Rowe, Ross (bib45) 1989; 28
Burden, Kingma, Froelich-Ammon, Bjornsti, Patchan, Thompson, Osheroff (bib64) 1996; 271
Danks, Schmidt, Deneka, Beck (bib67) 1989; 1
Elsea, Osheroff, Nitiss (bib31) 1992; 267
Lindsley, Wang (bib75) 1991; 88
Osheroff, Zechiedrich, Gale (bib11) 1991; 13
Hsiung, Elsea, Osheroff, Nitiss (bib55) 1995; 270
Halicka, Seiter, Feldman, Traganos, Mittelman, Ahmed, Darzynkiewicz (bib22) 1997; 2
Nitiss, Vilalta, Wu, McMahon (bib51) 1994; 46
Kim, Hirabayashi, Nishiyama, Jinushi, Toge, Okada (bib32) 1992; 12
Evans, Mirski, Danks, Cole (bib37) 1994; 34
Kreuzer, Cozzarelli (bib10) 1979; 140
Feldhoff, Mirski, Cole, Sullivan (bib38) 1994; 54
Cabral, Jackson, Smith, Shikotra, Maxwell, Liddington (bib76) 1997; 388
Son, Suh, Ahn, Kim, Yi, Hur, Hong, Muller, Chung (bib43) 1998; 41
Pommier, Leteurtre, Fesen, Fujimori, Bertrand, Solary, Kohlhagen, Kohn (bib52) 1994; 12
Robinson, Osheroff (bib72) 1991; 30
Li, Wang (bib74) 1997; 272
Jannatipour, Liu, Nitiss (bib47) 1993; 268
Wang, Morris-Natschke, Lee (bib9) 1997; 17
Berger, Wang (bib15) 1996; 6
Solary, Bertrand, Pommier (bib23) 1994; 15
Roca, Wang (bib69) 1992; 71
Berger, Gamblin, Harrison, Wang (bib73) 1996; 379
Ritke, Rusnak, Lazo, Allan, Dive, Heer, Yalowich (bib20) 1994; 46
Osheroff (bib70) 1989; 28
Osheroff, Zechiedrich (bib66) 1987; 26
Nitiss (bib50) 1994; 34
Roy, Brown, Little, Valentine, Walker, Sikorska, Leblanc, Chaly (bib18) 1992; 200
Wessel, Jensen, Falck, Mirski, Cole (bib41) 1997; 57
Sullivan, Latham, Ross (bib30) 1987; 47
Potmesil, Silber (bib24) 1990
Pommier (bib8) 1997; 1
Nitiss, Liu, Hsiung (bib34) 1993; 53
Nitiss, Rose, Sykes, Harris, Zhou (bib16) 1996; 803
Mirski, Evans, Almquist, Slovak, Cole (bib35) 1993; 53
Watt, Hickson (bib12) 1994; 303
Patel, Sprung, Keller, Heaton, Fisher (bib56) 1997; 52
Tartof (10.1074/jbc.273.44.29086_bib60) 1987; 9
Berger (10.1074/jbc.273.44.29086_bib15) 1996; 6
Jannatipour (10.1074/jbc.273.44.29086_bib47) 1993; 268
Pommier (10.1074/jbc.273.44.29086_bib8) 1997; 1
Sullivan (10.1074/jbc.273.44.29086_bib45) 1989; 28
Osheroff (10.1074/jbc.273.44.29086_bib68) 1986; 261
Berger (10.1074/jbc.273.44.29086_bib73) 1996; 379
Worland (10.1074/jbc.273.44.29086_bib59) 1989; 264
Elsea (10.1074/jbc.273.44.29086_bib31) 1992; 267
D'Arpa (10.1074/jbc.273.44.29086_bib36) 1994; 29
Robinson (10.1074/jbc.273.44.29086_bib72) 1991; 30
Kim (10.1074/jbc.273.44.29086_bib32) 1992; 12
Corbett (10.1074/jbc.273.44.29086_bib2) 1993; 6
Davies (10.1074/jbc.273.44.29086_bib27) 1990; 235
Roy (10.1074/jbc.273.44.29086_bib18) 1992; 200
Wasserman (10.1074/jbc.273.44.29086_bib53) 1994; 54
Potmesil (10.1074/jbc.273.44.29086_bib24) 1990
10.1074/jbc.273.44.29086_bib4
Alton (10.1074/jbc.273.44.29086_bib33) 1993; 85
Solary (10.1074/jbc.273.44.29086_bib23) 1994; 15
Pommier (10.1074/jbc.273.44.29086_bib52) 1994; 12
Chan (10.1074/jbc.273.44.29086_bib48) 1993; 268
Sullivan (10.1074/jbc.273.44.29086_bib30) 1987; 47
Ritke (10.1074/jbc.273.44.29086_bib20) 1994; 46
Chen (10.1074/jbc.273.44.29086_bib3) 1994; 34
Walker (10.1074/jbc.273.44.29086_bib17) 1991; 51
Froelich-Ammon (10.1074/jbc.273.44.29086_bib5) 1995; 270
Sinha (10.1074/jbc.273.44.29086_bib26) 1995; 49
Nitiss (10.1074/jbc.273.44.29086_bib51) 1994; 46
Strathern (10.1074/jbc.273.44.29086_bib62) 1991; 194
Harrison (10.1074/jbc.273.44.29086_bib39) 1995; 175
Elsea (10.1074/jbc.273.44.29086_bib54) 1995; 270
Malonne (10.1074/jbc.273.44.29086_bib42) 1997; 8
Hasegawa (10.1074/jbc.273.44.29086_bib40) 1995; 71
Bugg (10.1074/jbc.273.44.29086_bib46) 1991; 88
Feldhoff (10.1074/jbc.273.44.29086_bib38) 1994; 54
Osheroff (10.1074/jbc.273.44.29086_bib66) 1987; 26
Pommier (10.1074/jbc.273.44.29086_bib6) 1996
Ferguson (10.1074/jbc.273.44.29086_bib14) 1994; 24
Robinson (10.1074/jbc.273.44.29086_bib71) 1989; 29
Hsiung (10.1074/jbc.273.44.29086_bib55) 1995; 270
Mirski (10.1074/jbc.273.44.29086_bib35) 1993; 53
Nitiss (10.1074/jbc.273.44.29086_bib61) 1988; 85
Evans (10.1074/jbc.273.44.29086_bib37) 1994; 34
Patel (10.1074/jbc.273.44.29086_bib56) 1997; 52
Nitiss (10.1074/jbc.273.44.29086_bib7) 1996; 32a
Osheroff (10.1074/jbc.273.44.29086_bib11) 1991; 13
Kreuzer (10.1074/jbc.273.44.29086_bib10) 1979; 140
Smith (10.1074/jbc.273.44.29086_bib19) 1994; 69
Osheroff (10.1074/jbc.273.44.29086_bib70) 1989; 28
Lindsley (10.1074/jbc.273.44.29086_bib75) 1991; 88
Son (10.1074/jbc.273.44.29086_bib43) 1998; 41
Roca (10.1074/jbc.273.44.29086_bib69) 1992; 71
Li (10.1074/jbc.273.44.29086_bib74) 1997; 272
Nitiss (10.1074/jbc.273.44.29086_bib50) 1994; 34
Danks (10.1074/jbc.273.44.29086_bib67) 1989; 1
Sambrook (10.1074/jbc.273.44.29086_bib57) 1989
Zwelling (10.1074/jbc.273.44.29086_bib44) 1989; 264
Schiestl (10.1074/jbc.273.44.29086_bib58) 1989; 16
Wang (10.1074/jbc.273.44.29086_bib13) 1996; 65
Nitiss (10.1074/jbc.273.44.29086_bib28) 1992; 52
Wang (10.1074/jbc.273.44.29086_bib9) 1997; 17
Cabral (10.1074/jbc.273.44.29086_bib76) 1997; 388
Osheroff (10.1074/jbc.273.44.29086_bib65) 1983; 258
Nitiss (10.1074/jbc.273.44.29086_bib34) 1993; 53
Pommier (10.1074/jbc.273.44.29086_bib1) 1993; 32
Halicka (10.1074/jbc.273.44.29086_bib22) 1997; 2
(10.1074/jbc.273.44.29086_bib25) 1991
McPherson (10.1074/jbc.273.44.29086_bib29) 1997; 17
Wessel (10.1074/jbc.273.44.29086_bib41) 1997; 57
Sanger (10.1074/jbc.273.44.29086_bib63) 1977; 74
Watt (10.1074/jbc.273.44.29086_bib12) 1994; 303
Negri (10.1074/jbc.273.44.29086_bib21) 1995; 77
Liu (10.1074/jbc.273.44.29086_bib49) 1994; 54
Nitiss (10.1074/jbc.273.44.29086_bib16) 1996; 803
Burden (10.1074/jbc.273.44.29086_bib64) 1996; 271
References_xml – volume: 57
  start-page: 4451
  year: 1997
  end-page: 4454
  ident: bib41
  publication-title: Cancer Res.
  contributor:
    fullname: Cole
– volume: 16
  start-page: 339
  year: 1989
  end-page: 346
  ident: bib58
  publication-title: Curr. Genet.
  contributor:
    fullname: Gietz
– volume: 12
  start-page: 241
  year: 1992
  end-page: 245
  ident: bib32
  publication-title: Anticancer Res.
  contributor:
    fullname: Okada
– volume: 261
  start-page: 9944
  year: 1986
  end-page: 9950
  ident: bib68
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Osheroff
– volume: 71
  start-page: 907
  year: 1995
  end-page: 913
  ident: bib40
  publication-title: Br. J. Cancer
  contributor:
    fullname: Kuwano
– volume: 8
  start-page: 811
  year: 1997
  end-page: 822
  ident: bib42
  publication-title: Anti-Cancer Drugs
  contributor:
    fullname: Atassi
– volume: 13
  start-page: 269
  year: 1991
  end-page: 273
  ident: bib11
  publication-title: BioEssays
  contributor:
    fullname: Gale
– volume: 74
  start-page: 5463
  year: 1977
  end-page: 5467
  ident: bib63
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Coulson
– volume: 54
  start-page: 2943
  year: 1994
  end-page: 2951
  ident: bib49
  publication-title: Cancer Res.
  contributor:
    fullname: Nitiss
– volume: 88
  start-page: 7654
  year: 1991
  end-page: 7658
  ident: bib46
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Suttle
– volume: 267
  start-page: 13150
  year: 1992
  end-page: 13153
  ident: bib31
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Nitiss
– volume: 1
  start-page: 153
  year: 1997
  end-page: 174
  ident: bib8
  publication-title: Cancer Therapeutics: Experimental and Clinical Agents
  contributor:
    fullname: Pommier
– volume: 200
  start-page: 416
  year: 1992
  end-page: 424
  ident: bib18
  publication-title: Exp. Cell Res.
  contributor:
    fullname: Chaly
– volume: 85
  start-page: 241
  year: 1993
  end-page: 245
  ident: bib33
  publication-title: Br. J. Haematol.
  contributor:
    fullname: Harris
– volume: 88
  start-page: 10485
  year: 1991
  end-page: 10489
  ident: bib75
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Wang
– volume: 49
  start-page: 11
  year: 1995
  end-page: 19
  ident: bib26
  publication-title: Drugs
  contributor:
    fullname: Sinha
– volume: 34
  start-page: 191
  year: 1994
  end-page: 218
  ident: bib3
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  contributor:
    fullname: Liu
– volume: 17
  start-page: 367
  year: 1997
  end-page: 425
  ident: bib9
  publication-title: Med. Res. Rev.
  contributor:
    fullname: Lee
– volume: 77
  start-page: 893
  year: 1995
  end-page: 899
  ident: bib21
  publication-title: Biochimie (Paris)
  contributor:
    fullname: Scovassi
– volume: 388
  start-page: 903
  year: 1997
  end-page: 906
  ident: bib76
  publication-title: Nature
  contributor:
    fullname: Liddington
– volume: 65
  start-page: 635
  year: 1996
  end-page: 692
  ident: bib13
  publication-title: Annu. Rev. Biochem.
  contributor:
    fullname: Wang
– volume: 15
  start-page: 21
  year: 1994
  end-page: 32
  ident: bib23
  publication-title: Leuk. Lymphoma
  contributor:
    fullname: Pommier
– volume: 53
  start-page: 4866
  year: 1993
  end-page: 4873
  ident: bib35
  publication-title: Cancer Res.
  contributor:
    fullname: Cole
– volume: 264
  start-page: 4412
  year: 1989
  end-page: 4416
  ident: bib59
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Wang
– volume: 54
  start-page: 1795
  year: 1994
  end-page: 1800
  ident: bib53
  publication-title: Cancer Res.
  contributor:
    fullname: Wang
– volume: 34
  start-page: 242
  year: 1994
  end-page: 248
  ident: bib37
  publication-title: Cancer Chemother. Pharmacol.
  contributor:
    fullname: Cole
– volume: 272
  start-page: 31190
  year: 1997
  end-page: 31195
  ident: bib74
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Wang
– volume: 2
  start-page: 25
  year: 1997
  end-page: 39
  ident: bib22
  publication-title: Apoptosis
  contributor:
    fullname: Darzynkiewicz
– volume: 379
  start-page: 225
  year: 1996
  end-page: 232
  ident: bib73
  publication-title: Nature
  contributor:
    fullname: Wang
– volume: 175
  start-page: 7
  year: 1995
  end-page: 12
  ident: bib39
  publication-title: J. Pathol.
  contributor:
    fullname: Harrison
– volume: 258
  start-page: 9536
  year: 1983
  end-page: 9543
  ident: bib65
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Brutlag
– volume: 271
  start-page: 29238
  year: 1996
  end-page: 29244
  ident: bib64
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Osheroff
– volume: 194
  start-page: 319
  year: 1991
  end-page: 329
  ident: bib62
  publication-title: Methods Enzymol.
  contributor:
    fullname: Higgins
– volume: 9
  start-page: 2
  year: 1987
  end-page: 12
  ident: bib60
  publication-title: Focus
  contributor:
    fullname: Hobbs
– volume: 17
  start-page: 4243
  year: 1997
  end-page: 4252
  ident: bib29
  publication-title: Anticancer Res.
  contributor:
    fullname: Goldenberg
– volume: 52
  start-page: 658
  year: 1997
  end-page: 666
  ident: bib56
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Fisher
– volume: 54
  start-page: 756
  year: 1994
  end-page: 762
  ident: bib38
  publication-title: Cancer Res.
  contributor:
    fullname: Sullivan
– volume: 46
  start-page: 605
  year: 1994
  end-page: 611
  ident: bib20
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Yalowich
– volume: 268
  start-page: 18586
  year: 1993
  end-page: 18592
  ident: bib47
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Nitiss
– volume: 34
  start-page: S6
  year: 1994
  end-page: S13
  ident: bib50
  publication-title: Cancer Chemother. Pharmacol.
  contributor:
    fullname: Nitiss
– volume: 803
  start-page: 32
  year: 1996
  end-page: 43
  ident: bib16
  publication-title: Ann. N. Y. Acad. Sci.
  contributor:
    fullname: Zhou
– volume: 41
  start-page: 353
  year: 1998
  end-page: 360
  ident: bib43
  publication-title: Cancer Chemother. Pharmacol.
  contributor:
    fullname: Chung
– volume: 47
  start-page: 3973
  year: 1987
  end-page: 3979
  ident: bib30
  publication-title: Cancer Res.
  contributor:
    fullname: Ross
– volume: 71
  start-page: 833
  year: 1992
  end-page: 840
  ident: bib69
  publication-title: Cell
  contributor:
    fullname: Wang
– volume: 6
  start-page: 84
  year: 1996
  end-page: 90
  ident: bib15
  publication-title: Curr. Opin. Struct. Biol.
  contributor:
    fullname: Wang
– volume: 51
  start-page: 1078
  year: 1991
  end-page: 1085
  ident: bib17
  publication-title: Cancer Res.
  contributor:
    fullname: Sikorska
– volume: 235
  start-page: 111
  year: 1990
  end-page: 118
  ident: bib27
  publication-title: Mutat. Res.
  contributor:
    fullname: Hickson
– volume: 29
  start-page: 127
  year: 1994
  end-page: 143
  ident: bib36
  publication-title: Adv. Pharmacol.
  contributor:
    fullname: D'Arpa
– volume: 270
  start-page: 21429
  year: 1995
  end-page: 21432
  ident: bib5
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Osheroff
– volume: 28
  start-page: 5680
  year: 1989
  end-page: 5687
  ident: bib45
  publication-title: Biochemistry
  contributor:
    fullname: Ross
– volume: 29
  start-page: 2511
  year: 1989
  end-page: 2515
  ident: bib71
  publication-title: Biochemistry
  contributor:
    fullname: Osheroff
– volume: 264
  start-page: 16411
  year: 1989
  end-page: 16420
  ident: bib44
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Blick
– volume: 69
  start-page: S7
  year: 1994
  end-page: S11
  ident: bib19
  publication-title: Ann. Hematol.
  contributor:
    fullname: Cotter
– volume: 24
  start-page: 245
  year: 1994
  end-page: 261
  ident: bib14
  publication-title: Environ. Mol. Mutagen.
  contributor:
    fullname: Baguley
– volume: 268
  start-page: 2160
  year: 1993
  end-page: 2165
  ident: bib48
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Schnipper
– volume: 1
  start-page: 101
  year: 1989
  end-page: 109
  ident: bib67
  publication-title: Cancer Commun.
  contributor:
    fullname: Beck
– volume: 32a
  start-page: 958
  year: 1996
  end-page: 966
  ident: bib7
  publication-title: Eur. J. Cancer
  contributor:
    fullname: Beck
– volume: 303
  start-page: 681
  year: 1994
  end-page: 695
  ident: bib12
  publication-title: Biochem. J.
  contributor:
    fullname: Hickson
– year: 1991
  ident: bib25
  publication-title: DNA Topoisomerases in Cancer
– start-page: 9.31
  year: 1989
  end-page: 9.57
  ident: bib57
  publication-title: Molecular Cloning: A Laboratory Manual
  contributor:
    fullname: Maniatis
– volume: 140
  start-page: 424
  year: 1979
  end-page: 435
  ident: bib10
  publication-title: J. Bacteriol.
  contributor:
    fullname: Cozzarelli
– volume: 270
  start-page: 1913
  year: 1995
  end-page: 1920
  ident: bib54
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Osheroff
– volume: 85
  start-page: 7501
  year: 1988
  end-page: 7505
  ident: bib61
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Wang
– volume: 28
  start-page: 6157
  year: 1989
  end-page: 6160
  ident: bib70
  publication-title: Biochemistry
  contributor:
    fullname: Osheroff
– start-page: 435
  year: 1996
  end-page: 461
  ident: bib6
  publication-title: Cancer Chemotherapy and Biotherapy: Principles and Practice
  contributor:
    fullname: Goldwasser
– volume: 26
  start-page: 4303
  year: 1987
  end-page: 4309
  ident: bib66
  publication-title: Biochemistry
  contributor:
    fullname: Zechiedrich
– volume: 53
  start-page: 89
  year: 1993
  end-page: 93
  ident: bib34
  publication-title: Cancer Res.
  contributor:
    fullname: Hsiung
– volume: 12
  start-page: 530
  year: 1994
  end-page: 542
  ident: bib52
  publication-title: Cancer Invest.
  contributor:
    fullname: Kohn
– volume: 32
  start-page: 103
  year: 1993
  end-page: 108
  ident: bib1
  publication-title: Cancer Chemother. Pharmacol.
  contributor:
    fullname: Pommier
– volume: 6
  start-page: 585
  year: 1993
  end-page: 597
  ident: bib2
  publication-title: Chem. Res. Toxicol.
  contributor:
    fullname: Osheroff
– start-page: 391
  year: 1990
  end-page: 407
  ident: bib24
  publication-title: DNA Topology and Its Biological Effects
  contributor:
    fullname: Silber
– volume: 270
  start-page: 20359
  year: 1995
  end-page: 20364
  ident: bib55
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Nitiss
– volume: 46
  start-page: 773
  year: 1994
  end-page: 777
  ident: bib51
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: McMahon
– volume: 52
  start-page: 4467
  year: 1992
  end-page: 4472
  ident: bib28
  publication-title: Cancer Res.
  contributor:
    fullname: Wang
– volume: 30
  start-page: 1807
  year: 1991
  end-page: 1813
  ident: bib72
  publication-title: Biochemistry
  contributor:
    fullname: Osheroff
– ident: 10.1074/jbc.273.44.29086_bib4
– volume: 1
  start-page: 153
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib8
  contributor:
    fullname: Pommier
– volume: 85
  start-page: 7501
  year: 1988
  ident: 10.1074/jbc.273.44.29086_bib61
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.85.20.7501
  contributor:
    fullname: Nitiss
– volume: 32a
  start-page: 958
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib7
  publication-title: Eur. J. Cancer
  doi: 10.1016/0959-8049(96)00056-1
  contributor:
    fullname: Nitiss
– volume: 47
  start-page: 3973
  year: 1987
  ident: 10.1074/jbc.273.44.29086_bib30
  publication-title: Cancer Res.
  contributor:
    fullname: Sullivan
– volume: 53
  start-page: 4866
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib35
  publication-title: Cancer Res.
  contributor:
    fullname: Mirski
– volume: 34
  start-page: 191
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib3
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev.pa.34.040194.001203
  contributor:
    fullname: Chen
– volume: 12
  start-page: 241
  year: 1992
  ident: 10.1074/jbc.273.44.29086_bib32
  publication-title: Anticancer Res.
  contributor:
    fullname: Kim
– volume: 28
  start-page: 6157
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib70
  publication-title: Biochemistry
  doi: 10.1021/bi00441a005
  contributor:
    fullname: Osheroff
– volume: 140
  start-page: 424
  year: 1979
  ident: 10.1074/jbc.273.44.29086_bib10
  publication-title: J. Bacteriol.
  doi: 10.1128/jb.140.2.424-435.1979
  contributor:
    fullname: Kreuzer
– volume: 2
  start-page: 25
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib22
  publication-title: Apoptosis
  doi: 10.1023/A:1026431524236
  contributor:
    fullname: Halicka
– start-page: 435
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib6
  contributor:
    fullname: Pommier
– volume: 53
  start-page: 89
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib34
  publication-title: Cancer Res.
  contributor:
    fullname: Nitiss
– volume: 270
  start-page: 21429
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib5
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.37.21429
  contributor:
    fullname: Froelich-Ammon
– volume: 803
  start-page: 32
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib16
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1996.tb26374.x
  contributor:
    fullname: Nitiss
– volume: 88
  start-page: 7654
  year: 1991
  ident: 10.1074/jbc.273.44.29086_bib46
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.88.17.7654
  contributor:
    fullname: Bugg
– volume: 69
  start-page: S7
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib19
  publication-title: Ann. Hematol.
  doi: 10.1007/BF01757348
  contributor:
    fullname: Smith
– volume: 9
  start-page: 2
  year: 1987
  ident: 10.1074/jbc.273.44.29086_bib60
  publication-title: Focus
  contributor:
    fullname: Tartof
– volume: 16
  start-page: 339
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib58
  publication-title: Curr. Genet.
  doi: 10.1007/BF00340712
  contributor:
    fullname: Schiestl
– year: 1991
  ident: 10.1074/jbc.273.44.29086_bib25
– volume: 49
  start-page: 11
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib26
  publication-title: Drugs
  doi: 10.2165/00003495-199549010-00002
  contributor:
    fullname: Sinha
– volume: 264
  start-page: 16411
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib44
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)84722-1
  contributor:
    fullname: Zwelling
– volume: 30
  start-page: 1807
  year: 1991
  ident: 10.1074/jbc.273.44.29086_bib72
  publication-title: Biochemistry
  doi: 10.1021/bi00221a012
  contributor:
    fullname: Robinson
– volume: 71
  start-page: 907
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib40
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1995.177
  contributor:
    fullname: Hasegawa
– volume: 388
  start-page: 903
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib76
  publication-title: Nature
  doi: 10.1038/42294
  contributor:
    fullname: Cabral
– volume: 270
  start-page: 1913
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib54
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.4.1913
  contributor:
    fullname: Elsea
– volume: 32
  start-page: 103
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib1
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/BF00685611
  contributor:
    fullname: Pommier
– volume: 267
  start-page: 13150
  year: 1992
  ident: 10.1074/jbc.273.44.29086_bib31
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)42185-0
  contributor:
    fullname: Elsea
– volume: 54
  start-page: 756
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib38
  publication-title: Cancer Res.
  contributor:
    fullname: Feldhoff
– volume: 88
  start-page: 10485
  year: 1991
  ident: 10.1074/jbc.273.44.29086_bib75
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.88.23.10485
  contributor:
    fullname: Lindsley
– volume: 303
  start-page: 681
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib12
  publication-title: Biochem. J.
  doi: 10.1042/bj3030681
  contributor:
    fullname: Watt
– volume: 54
  start-page: 2943
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib49
  publication-title: Cancer Res.
  contributor:
    fullname: Liu
– volume: 29
  start-page: 2511
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib71
  publication-title: Biochemistry
  doi: 10.1021/bi00462a012
  contributor:
    fullname: Robinson
– volume: 17
  start-page: 367
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib9
  publication-title: Med. Res. Rev.
  doi: 10.1002/(SICI)1098-1128(199707)17:4<367::AID-MED3>3.0.CO;2-U
  contributor:
    fullname: Wang
– volume: 6
  start-page: 84
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib15
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/S0959-440X(96)80099-6
  contributor:
    fullname: Berger
– volume: 1
  start-page: 101
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib67
  publication-title: Cancer Commun.
  doi: 10.3727/095535489820875309
  contributor:
    fullname: Danks
– volume: 77
  start-page: 893
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib21
  publication-title: Biochimie (Paris)
  doi: 10.1016/0300-9084(95)90009-8
  contributor:
    fullname: Negri
– volume: 52
  start-page: 658
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib56
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.52.4.658
  contributor:
    fullname: Patel
– volume: 52
  start-page: 4467
  year: 1992
  ident: 10.1074/jbc.273.44.29086_bib28
  publication-title: Cancer Res.
  contributor:
    fullname: Nitiss
– volume: 175
  start-page: 7
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib39
  publication-title: J. Pathol.
  doi: 10.1002/path.1711750103
  contributor:
    fullname: Harrison
– volume: 264
  start-page: 4412
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib59
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)83757-7
  contributor:
    fullname: Worland
– volume: 24
  start-page: 245
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib14
  publication-title: Environ. Mol. Mutagen.
  doi: 10.1002/em.2850240402
  contributor:
    fullname: Ferguson
– volume: 6
  start-page: 585
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib2
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx00035a001
  contributor:
    fullname: Corbett
– volume: 13
  start-page: 269
  year: 1991
  ident: 10.1074/jbc.273.44.29086_bib11
  publication-title: BioEssays
  doi: 10.1002/bies.950130603
  contributor:
    fullname: Osheroff
– volume: 200
  start-page: 416
  year: 1992
  ident: 10.1074/jbc.273.44.29086_bib18
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(92)90190-J
  contributor:
    fullname: Roy
– volume: 268
  start-page: 2160
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib48
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)53976-4
  contributor:
    fullname: Chan
– volume: 57
  start-page: 4451
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib41
  publication-title: Cancer Res.
  contributor:
    fullname: Wessel
– volume: 71
  start-page: 833
  year: 1992
  ident: 10.1074/jbc.273.44.29086_bib69
  publication-title: Cell
  doi: 10.1016/0092-8674(92)90558-T
  contributor:
    fullname: Roca
– volume: 235
  start-page: 111
  year: 1990
  ident: 10.1074/jbc.273.44.29086_bib27
  publication-title: Mutat. Res.
  doi: 10.1016/0921-8777(90)90064-C
  contributor:
    fullname: Davies
– volume: 26
  start-page: 4303
  year: 1987
  ident: 10.1074/jbc.273.44.29086_bib66
  publication-title: Biochemistry
  doi: 10.1021/bi00388a018
  contributor:
    fullname: Osheroff
– volume: 46
  start-page: 605
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib20
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Ritke
– volume: 34
  start-page: 242
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib37
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/BF00685084
  contributor:
    fullname: Evans
– volume: 28
  start-page: 5680
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib45
  publication-title: Biochemistry
  doi: 10.1021/bi00439a051
  contributor:
    fullname: Sullivan
– volume: 15
  start-page: 21
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib23
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428199409051674
  contributor:
    fullname: Solary
– volume: 41
  start-page: 353
  year: 1998
  ident: 10.1074/jbc.273.44.29086_bib43
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s002800050751
  contributor:
    fullname: Son
– volume: 258
  start-page: 9536
  year: 1983
  ident: 10.1074/jbc.273.44.29086_bib65
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)44700-4
  contributor:
    fullname: Osheroff
– volume: 51
  start-page: 1078
  year: 1991
  ident: 10.1074/jbc.273.44.29086_bib17
  publication-title: Cancer Res.
  contributor:
    fullname: Walker
– volume: 46
  start-page: 773
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib51
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Nitiss
– volume: 54
  start-page: 1795
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib53
  publication-title: Cancer Res.
  contributor:
    fullname: Wasserman
– volume: 379
  start-page: 225
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib73
  publication-title: Nature
  doi: 10.1038/379225a0
  contributor:
    fullname: Berger
– start-page: 9.31
  year: 1989
  ident: 10.1074/jbc.273.44.29086_bib57
  contributor:
    fullname: Sambrook
– volume: 29
  start-page: 127
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib36
  publication-title: Adv. Pharmacol.
  doi: 10.1016/S1054-3589(08)61135-7
  contributor:
    fullname: D'Arpa
– volume: 261
  start-page: 9944
  year: 1986
  ident: 10.1074/jbc.273.44.29086_bib68
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)67607-0
  contributor:
    fullname: Osheroff
– volume: 271
  start-page: 29238
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib64
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.46.29238
  contributor:
    fullname: Burden
– volume: 65
  start-page: 635
  year: 1996
  ident: 10.1074/jbc.273.44.29086_bib13
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.bi.65.070196.003223
  contributor:
    fullname: Wang
– volume: 270
  start-page: 20359
  year: 1995
  ident: 10.1074/jbc.273.44.29086_bib55
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.35.20359
  contributor:
    fullname: Hsiung
– volume: 34
  start-page: S6
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib50
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/BF00684857
  contributor:
    fullname: Nitiss
– volume: 85
  start-page: 241
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib33
  publication-title: Br. J. Haematol.
  doi: 10.1111/j.1365-2141.1993.tb03162.x
  contributor:
    fullname: Alton
– volume: 8
  start-page: 811
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib42
  publication-title: Anti-Cancer Drugs
  doi: 10.1097/00001813-199710000-00001
  contributor:
    fullname: Malonne
– volume: 268
  start-page: 18586
  year: 1993
  ident: 10.1074/jbc.273.44.29086_bib47
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)46668-3
  contributor:
    fullname: Jannatipour
– volume: 12
  start-page: 530
  year: 1994
  ident: 10.1074/jbc.273.44.29086_bib52
  publication-title: Cancer Invest.
  doi: 10.3109/07357909409021413
  contributor:
    fullname: Pommier
– start-page: 391
  year: 1990
  ident: 10.1074/jbc.273.44.29086_bib24
  contributor:
    fullname: Potmesil
– volume: 74
  start-page: 5463
  year: 1977
  ident: 10.1074/jbc.273.44.29086_bib63
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.74.12.5463
  contributor:
    fullname: Sanger
– volume: 272
  start-page: 31190
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib74
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.49.31190
  contributor:
    fullname: Li
– volume: 17
  start-page: 4243
  year: 1997
  ident: 10.1074/jbc.273.44.29086_bib29
  publication-title: Anticancer Res.
  contributor:
    fullname: McPherson
– volume: 194
  start-page: 319
  year: 1991
  ident: 10.1074/jbc.273.44.29086_bib62
  publication-title: Methods Enzymol.
  doi: 10.1016/0076-6879(91)94024-7
  contributor:
    fullname: Strathern
SSID ssj0000491
Score 1.6874942
Snippet To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant...
To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic system was used to select a mutant...
SourceID proquest
crossref
pubmed
highwire
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 29086
SubjectTerms Adenosine Triphosphate - pharmacology
Antineoplastic Agents - pharmacology
DNA Topoisomerases, Type II - chemistry
DNA Topoisomerases, Type II - drug effects
DNA Topoisomerases, Type II - genetics
Drug Resistance, Neoplasm
Enzyme Stability
Glycine - genetics
Mutagenesis
Saccharomyces cerevisiae
Saccharomyces cerevisiae - enzymology
Serine - genetics
Title A Mutant Yeast Topoisomerase II (top2G437S) with Differential Sensitivity to Anticancer Drugs in the Presence and Absence of ATP
URI https://dx.doi.org/10.1074/jbc.273.44.29086
http://www.jbc.org/content/273/44/29086.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9786915
https://search.proquest.com/docview/17092773
Volume 273
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9NAFB6FIkQvCFoqQinMASGqyMHLeDuGCkhAVKCmUm-jGc8Y9RA7SuxDeuLIz-bN4oWUIOBiWR5v8vf56Zs3b0HoJfFdpmSCw3LJHCK8xGEsF47gjPBIylC4Kt_583k0vSQfr8KrweBHL2qprvg4u_ltXsn_oArHAFeVJfsPyLY3hQOwD_jCFhCG7V9hPBktatUFeLRRHXhARi7L63Wp3ExrOZrNlHqEY_4HEsQXavqvna5NS5RKp4qo-HXbQAJUKNxLmcVMtQ1f1d_WTRTkUicp2dwCxs2-0rDzL3112-WZaYVrCjyZEiRNX7nWo6MiolemgEHr_Hm7MQ7pzsE6ZUXBtOfnosuZOFd1mAz_bNKEaPP4lL13-6ZYxYb4pm57Y4p909bEco6QvmVNXVMz-5bNBxGkbD7PxnD5mJDxrVMBteVCcwDmzFFq8ke3ymzbkTvorg8mS9nKT1-7uvMwjzK9F-1L2wVvePSb7Qfvo3v2XrukTluJevesRqub-UP0wIKGJ4Zjj9BAFgfocFKwqlxs8CusA4X1CswBun_WgHmIvk-woSDWFMS_UBDPZvh1S8BTrOiH-_TDPfrBpbijH9b0w9cFBvrhhn5wgsCWfrjMMdDvMbp8_25-NnVsUw8nIySuHD8QIJk9HqQy5JIlXArPkzJ1_Yh7XMJ83c3i0MtkLpjvudzlQR66uSdZQHwZieAI7RVlIZ8gHCRhBPo-FzkHXZwnKUj7JIf5SxIyAEwO0Wnz_enS1G6hOuYiJhRQo4AaJYRq1IYoaACiVnsaTUmBZn-46qTBksI_pf6lrfEXDcAUgFFrcayQZb2mXuymfhwHQ3RkcG_f0JLn6a6BY7Tf_U_P0F61quUJCOOKP9ec_Qlne7VX
link.rule.ids 315,783,787,27936,27937
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+mutant+yeast+topoisomerase+II+%28top2G437S%29+with+differential+sensitivity+to+anticancer+drugs+in+the+presence+and+absence+of+ATP&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Sabourin%2C+M&rft.au=Byl%2C+J+A&rft.au=Hannah%2C+S+E&rft.au=Nitiss%2C+J+L&rft.date=1998-10-30&rft.issn=0021-9258&rft.volume=273&rft.issue=44&rft.spage=29086&rft_id=info:doi/10.1074%2Fjbc.273.44.29086&rft_id=info%3Apmid%2F9786915&rft.externalDocID=9786915
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon