Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling

Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in...

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Published inFrontiers in neuroscience Vol. 16; p. 1065411
Main Authors Zhou, Qianling, Li, Meng, Fan, Qisen, Chen, Feng, Jiang, Guihua, Wang, Tianyue, He, Qinmeng, Fu, Shishun, Yin, Yi, Lin, Jinzhi, Yan, Jianhao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 16.12.2022
Frontiers Media S.A
Subjects
Age
Alcoholism
Anxiety
arterial spin labeling
Blood flow
Brain
Cerebral blood flow
Chronic pain
Cognitive ability
Contraindications
Correlation analysis
Drug abuse
Frontal gyrus
Functional magnetic resonance imaging
functional MRI
Magnetic resonance imaging
Metabolism
Neuralgia
Neuroimaging
Neuroscience
Pain perception
Pathogenesis
Patients
Perfusion
Spin labeling
Structure-function relationships
Thalamus
Trigeminal nerve
trigeminal neuralgia
functional MRI
cerebral blood flow
chronic pain
brain
trigeminal neuralgia
arterial spin labeling
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Abstract Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. This study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. Compared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN.
AbstractList Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. This study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. Compared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN.
Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in TN patients. This study aimed to explore whether altered cerebral perfusion patterns exist in TN patients and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. This study included 28 patients with TN and 30 age- and sex-matched healthy controls who underwent perfusion functional MRI of the brain using pseudo-continuous arterial spin labeling in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Pearson’s correlation analysis was performed to illustrate the relationship between the clinical characteristics and abnormal rCBF. Compared to the control group, TN patients exhibited increased rCBF, primarily in the thalamus, left insula, and bilateral middle frontal gyrus. Furthermore, the CBF values of the thalamus were negatively correlated with pain intensity of TN and positively correlated with pain duration in patients with TN. Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding of the neuropathological mechanism underlying TN.
BackgroundAccumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. Materials and methodsThis study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. ResultsCompared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. ConclusionPrimary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN.
Background Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. Materials and methods This study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. Results Compared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. Conclusion Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN.
Author Zhou, Qianling
Wang, Tianyue
Fu, Shishun
Fan, Qisen
Yan, Jianhao
Li, Meng
Jiang, Guihua
Yin, Yi
Lin, Jinzhi
Chen, Feng
He, Qinmeng
AuthorAffiliation 2 Department of Medical Imaging, Guangdong Second Provincial General Hospital , Guangzhou , China
1 The Second School of Clinical Medicine, Southern Medical University , Guangzhou , China
4 Department of Neurosurgery, Guangdong Second Provincial General Hospital , Guangzhou , China
3 Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , China
AuthorAffiliation_xml – name: 1 The Second School of Clinical Medicine, Southern Medical University , Guangzhou , China
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Copyright © 2022 Zhou, Li, Fan, Chen, Jiang, Wang, He, Fu, Yin, Lin and Yan. 2022 Zhou, Li, Fan, Chen, Jiang, Wang, He, Fu, Yin, Lin and Yan
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Keywords functional MRI
cerebral blood flow
chronic pain
brain
trigeminal neuralgia
arterial spin labeling
Language English
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Edited by: Yilong Ma, Feinstein Institute for Medical Research, United States
This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience
These authors have contributed equally to this work
Reviewed by: Timothy White, Northwell Health, United States; Jun Zhong, Shanghai Jiao Tong University, China
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Snippet Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have...
Background Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies...
BackgroundAccumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies...
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StartPage 1065411
SubjectTerms Age
Alcoholism
Anxiety
arterial spin labeling
Blood flow
Brain
Cerebral blood flow
Chronic pain
Cognitive ability
Contraindications
Correlation analysis
Drug abuse
Frontal gyrus
Functional magnetic resonance imaging
functional MRI
Magnetic resonance imaging
Metabolism
Neuralgia
Neuroimaging
Neuroscience
Pain perception
Pathogenesis
Patients
Perfusion
Spin labeling
Structure-function relationships
Thalamus
Trigeminal nerve
trigeminal neuralgia
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Title Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling
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