Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling
Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in...
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Published in | Frontiers in neuroscience Vol. 16; p. 1065411 |
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Abstract | Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN.
This study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated.
Compared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN.
Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN. |
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AbstractList | Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN.
This study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated.
Compared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN.
Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN. Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in TN patients. This study aimed to explore whether altered cerebral perfusion patterns exist in TN patients and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. This study included 28 patients with TN and 30 age- and sex-matched healthy controls who underwent perfusion functional MRI of the brain using pseudo-continuous arterial spin labeling in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Pearson’s correlation analysis was performed to illustrate the relationship between the clinical characteristics and abnormal rCBF. Compared to the control group, TN patients exhibited increased rCBF, primarily in the thalamus, left insula, and bilateral middle frontal gyrus. Furthermore, the CBF values of the thalamus were negatively correlated with pain intensity of TN and positively correlated with pain duration in patients with TN. Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding of the neuropathological mechanism underlying TN. BackgroundAccumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. Materials and methodsThis study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. ResultsCompared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. ConclusionPrimary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN. Background Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. Materials and methods This study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. Results Compared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. Conclusion Primary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN. |
Author | Zhou, Qianling Wang, Tianyue Fu, Shishun Fan, Qisen Yan, Jianhao Li, Meng Jiang, Guihua Yin, Yi Lin, Jinzhi Chen, Feng He, Qinmeng |
AuthorAffiliation | 2 Department of Medical Imaging, Guangdong Second Provincial General Hospital , Guangzhou , China 1 The Second School of Clinical Medicine, Southern Medical University , Guangzhou , China 4 Department of Neurosurgery, Guangdong Second Provincial General Hospital , Guangzhou , China 3 Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , China |
AuthorAffiliation_xml | – name: 1 The Second School of Clinical Medicine, Southern Medical University , Guangzhou , China – name: 2 Department of Medical Imaging, Guangdong Second Provincial General Hospital , Guangzhou , China – name: 4 Department of Neurosurgery, Guangdong Second Provincial General Hospital , Guangzhou , China – name: 3 Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , China |
Author_xml | – sequence: 1 givenname: Qianling surname: Zhou fullname: Zhou, Qianling organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 2 givenname: Meng surname: Li fullname: Li, Meng organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 3 givenname: Qisen surname: Fan fullname: Fan, Qisen organization: Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China – sequence: 4 givenname: Feng surname: Chen fullname: Chen, Feng organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 5 givenname: Guihua surname: Jiang fullname: Jiang, Guihua organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 6 givenname: Tianyue surname: Wang fullname: Wang, Tianyue organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 7 givenname: Qinmeng surname: He fullname: He, Qinmeng organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 8 givenname: Shishun surname: Fu fullname: Fu, Shishun organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 9 givenname: Yi surname: Yin fullname: Yin, Yi organization: Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 10 givenname: Jinzhi surname: Lin fullname: Lin, Jinzhi organization: Department of Neurosurgery, Guangdong Second Provincial General Hospital, Guangzhou, China – sequence: 11 givenname: Jianhao surname: Yan fullname: Yan, Jianhao organization: The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China |
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Keywords | functional MRI cerebral blood flow chronic pain brain trigeminal neuralgia arterial spin labeling |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Yilong Ma, Feinstein Institute for Medical Research, United States This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience These authors have contributed equally to this work Reviewed by: Timothy White, Northwell Health, United States; Jun Zhong, Shanghai Jiao Tong University, China |
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Snippet | Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have... Background Accumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies... BackgroundAccumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies... |
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SubjectTerms | Age Alcoholism Anxiety arterial spin labeling Blood flow Brain Cerebral blood flow Chronic pain Cognitive ability Contraindications Correlation analysis Drug abuse Frontal gyrus Functional magnetic resonance imaging functional MRI Magnetic resonance imaging Metabolism Neuralgia Neuroimaging Neuroscience Pain perception Pathogenesis Patients Perfusion Spin labeling Structure-function relationships Thalamus Trigeminal nerve trigeminal neuralgia |
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Title | Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling |
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