The Auxiliary Subunits Neto1 and Neto2 Reduce Voltage-Dependent Inhibition of Recombinant Kainate Receptors

• Published in: The Journal of neuroscience Vol. 32; no. 37; pp. 12928 - 12933
• Main Authors: Fisher, Janet L., Mott, David D.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 12.09.2012
• Subjects: Brief Communications; Calcium - metabolism; Ion Channel Gating - physiology; Membrane Potentials - physiology; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Protein Subunits; Structure-Activity Relationship

Kainate receptors can be subject to voltage-dependent block by intracellular polyamines, which causes inward rectification of the current–voltage relationship. Sensitivity to polyamine block is largely determined by the identity of a residue within the pore domain that can be altered through RNA edi...