Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: Role of CGRP and TRPV1 receptors

• Published in: European journal of pharmacology Vol. 615; no. 1; pp. 177 - 184
• Main Authors: De Winter, Benedicte Y., Bredenoord, Albert J., Van Nassauw, Luc, De Man, Joris G., De Schepper, Heiko U., Timmermans, Jean-Pierre, Pelckmans, Paul A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.08.2009; Elsevier
• Subjects: Afferent neuron; Animals; Biological and medical sciences; Calcitonin Gene-Related Peptide - pharmacology; Capsaicin - pharmacology; CGRP; Endotoxin; Gastric Emptying - drug effects; Gastric Emptying - physiology; Gastrointestinal Transit - drug effects; Gastrointestinal Transit - physiology; Hexamethonium - pharmacology; Ileus - metabolism; Ileus - physiopathology; Lipopolysaccharides - pharmacology; Male; Medical sciences; Mice; Motility; Neurons, Afferent - drug effects; Neurons, Afferent - physiology; Peptide Fragments - pharmacology; Pharmacology. Drug treatments; Pyrazines - pharmacology; Pyridines - pharmacology; Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors; Receptors, Calcitonin Gene-Related Peptide - physiology; Sepsis; Sepsis - metabolism; Sepsis - physiopathology; TRPV Cation Channels - antagonists & inhibitors; TRPV Cation Channels - physiology; TRPV1; Sepsis; Motility; TRPV1; Afferent neuron; Endotoxin; CGRP; Pathogenesis; Rodentia; Calcitonin gene related peptide; Neuropeptide; Infection; Sepsis syndrome; Toxin; Vertebrata; VR1 vanilloid receptor; TRPV1 vanilloid receptor; Mammalia; Neuron; Mouse; Animal; CGRP receptor

Activation of neuronal reflex pathways by inflammatory mediators is postulated as an important pathogenic mechanism in postoperative ileus. In this study, we investigated the involvement of afferent neurons and more specifically the role of the transient receptor potential vanilloid receptor type 1...