Pharmacokinetics of once-daily boosted elvitegravir when administered in combination with acid-reducing agents

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 64; no. 1; p. 45
• Main Authors: Ramanathan, Srinivasan, Mathias, Anita, Wei, Xuelian, Shen, Gong, Koziara, Joanna, Cheng, Andrew, Kearney, Brian P
• Format: Journal Article
• Language: English
• Published: United States 01.09.2013
• Subjects: Adolescent; Adult; Antacids - administration & dosage; Antacids - pharmacology; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - pharmacology; Area Under Curve; Carbamates - administration & dosage; Carbamates - pharmacology; Cobicistat; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinolones - administration & dosage; Quinolones - pharmacokinetics; Thiazoles - administration & dosage; Thiazoles - pharmacology

Acid-reducing agents are commonly used co-medications by HIV-1-infected patients receiving antiretroviral treatment. The effects of various representative acid-reducing agents on the pharmacokinetics (PK) of boosted elvitegravir were evaluated by 1-way interaction in 4 studies. Healthy subjects rece...