Pharmacokinetic characterization of a human immunodeficiency virus protease inhibitor, saquinavir, during ethanol intake in rats

• Published in: Biopharmaceutics & drug disposition Vol. 24; no. 8; pp. 335 - 344
• Main Authors: Shibata, Nobuhito, Kageyama, Michiharu, Kishida, Tomoyuki, Kimura, Keisuke, Yoshikawa, Yukako, Kuwahara, Takeshi, Toh, Jyunichiro, Shirasaka, Takuma, Takada, Kanji
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2003; Wiley
• Subjects: Administration, Oral; Administration, Rectal; Alcohol Drinking - blood; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral Therapy, Highly Active; Antiviral agents; Biological and medical sciences; Drug Monitoring; Ethanol - administration & dosage; ethanol intake; HIV Infections - blood; HIV Infections - drug therapy; HIV protease inhibitor; HIV Protease Inhibitors - blood; HIV Protease Inhibitors - pharmacokinetics; HIV Protease Inhibitors - therapeutic use; Humans; Injections, Intravenous; Male; Medical sciences; Metabolic Clearance Rate - drug effects; pharmacokinetic interaction; Pharmacology. Drug treatments; Rats; Rats, Wistar; ritonavir; Ritonavir - blood; Ritonavir - pharmacokinetics; Ritonavir - therapeutic use; saquinavir; Saquinavir - blood; Saquinavir - pharmacokinetics; Saquinavir - therapeutic use; Drug alcohol interaction; Rat; HIV protease inhibitor; Blood plasma; Saquinavir; ritonavir; Antiviral; Consumption; pharmacokinetic interaction; Ethanol; Enzyme; Rodentia; Oral administration; Enzyme inhibitor; Retroviridae; Lentivirus; ethanol intake; Virus; Peptidases; Vertebrata; Chemotherapy; Mammalia; Animal; Hydrolases; Human immunodeficiency virus; Pharmacokinetics; Protease inhibitor

Throughout therapeutic drug monitoring of human immunodeficiency virus (HIV) protease inhibitors in HIV‐infected patients, it was found that plasma concentrations of saquinavir (SQV) were reduced in patients who had a habit of alcohol intake during double protease therapy with SQV and ritonavir (RTV...