Sirolimus‐Associated Infertility: Case Report and Literature Review of Possible Mechanisms

• Published in: American journal of transplantation Vol. 7; no. 10; pp. 2414 - 2421
• Main Authors: Deutsch, M. A., Kaczmarek, I., Huber, S., Schmauss, D., Beiras‐Fernandez, A., Schmoeckel, M., Ochsenkuehn, R., Meiser, B., Mueller‐Hoecker, J., Bruno Reichart, B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2007; Blackwell
• Subjects: Adult; Biological and medical sciences; Birth control; Gynecology. Andrology. Obstetrics; Heart transplantation; Heart-Lung Transplantation - immunology; Humans; immunosuppression; Immunosuppressive Agents - adverse effects; Infertility, Male - chemically induced; Leydig Cell Tumor - chemically induced; Leydig Cell Tumor - pathology; Leydig Cell Tumor - surgery; Male; Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance; Medical sciences; Middle Aged; oligospermia; sirolimus; Sirolimus - adverse effects; Sterility. Assisted procreation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; tertiality; Testicular Neoplasms - chemically induced; Testicular Neoplasms - pathology; Testicular Neoplasms - surgery; Tissue Donors; Antineoplastic agent; Heart; Sirolimus; Transplantation; Homotransplantation; Mechanism; Macrocycle; Surgery; Graft; Protein synthesis inhibitor; tertiality; Male genital diseases; Human; Heart transplantation; Lactone; Macrolide; Sterility; Semen disorders; Oligospermia; Case study; Antibiotic; Immunosuppression; Treatment; Circulatory system; Immunosuppressive agent; Antibacterial agent; Bibliographic review

The mammalian‐target‐of‐rapamycin/mTOR‐inhibitor sirolimus as a component of the immunosuppressive strategy after solid organ transplantation is effective at preventing allograft rejection. However, recent reports indicate that sirolimus is associated with altered sex hormone levels and impaired spe...