Anticancer Water‐Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation

• Published in: Chembiochem : a European journal of chemical biology Vol. 23; no. 18; pp. e202200259 - n/a
• Main Authors: Azmanova, Maria, Rafols, Laia, Cooper, Patricia A., Seaton, Colin C., Shnyder, Steven D., Pitto‐Barry, Anaïs
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 16.09.2022; Wiley-VCH Verlag
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis; Biocompatibility; bioinorganic chemistry; Cancer; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chemical Sciences; Coordination Complexes - toxicity; Coordination compounds; Cytotoxicity; Drug Screening Assays, Antitumor; Female; half-sandwich complexes; Humans; In vivo methods and tests; in vivo evaluation; Life Sciences; Ligands; Lung cancer; Lung Neoplasms; Medicinal Chemistry; Metal complexes; metallodrugs; Organophosphorus Compounds; Organoruthenium complexes; Ovarian cancer; Ovarian Neoplasms; Phosphine; phosphine ligands; Phosphines; Prostate; Prostate cancer; Reactive Oxygen Species; Ruthenium; Ruthenium - pharmacology; Ruthenium compounds; Synthesis; Toxicity; Tumor cell lines; Tumors; Water; Xenografts; Xenotransplantation; in vivo evaluation; half-sandwich complexes; metallodrugs; phosphine ligands; bioinorganic chemistry; phosphines; ligands; antineoplastic agents; drug screening assays; in vivo evaluation; lung neoplasms; antitumor; water; organophosphorus compounds; ovarian neoplasms; ruthenium; carcinoma; tumor; reactive oxygen species; non-small-cell lung; female; coordination complexes; humans; cell line

The synthesis, characterisation, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate‐based ruthenium metal complexes bearing various phosphine ligands towards two ovarian cancer cell lines (A2780 and A2780cisR), one non‐small‐cell lung cancer cell line (H460) and one normal pr...