Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray

Summary A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell‐capture technique in which 82 antigens are studied simultaneously. This paper presents the analysis of 733 patients with a variety of leukaemias and l...

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Published inBritish journal of haematology Vol. 135; no. 2; pp. 184 - 197
Main Authors Belov, Larissa, Mulligan, Stephen P., Barber, Nicole, Woolfson, Adrian, Scott, Mike, Stoner, Kerryn, Chrisp, Jeremy S., Sewell, William A., Bradstock, Kenneth F., Bendall, Linda, Pascovici, Dana S., Thomas, Mervyn, Erber, Wendy, Huang, Pauline, Sartor, Mary, Young, Graham A.R., Wiley, James S., Juneja, Surender, Wierda, William G., Green, Anthony R., Keating, Michael J., Christopherson, Richard I.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2006
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Abstract Summary A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell‐capture technique in which 82 antigens are studied simultaneously. This paper presents the analysis of 733 patients with a variety of leukaemias and lymphomas from peripheral blood and bone marrow. Discriminant Function Analysis of the expression profiles from these 733 patients and 63 normal subjects were clustered and showed high levels of consistency with diagnoses obtained using conventional clinical and laboratory criteria. The overall levels of consensus for classification using the microarray compared with established criteria were 93·9% (495/527 patients) for peripheral blood and 97·6% (201/206 patients) for bone marrow aspirates, showing that the extensive phenotype alone was frequently able to classify the disease when the leukaemic clone was the dominant cell population present. Immunophenotypes for neoplastic cells were distinguishable from normal cells when the leukaemic cell count was at least 5 × 109 cells/l in peripheral blood, or 20% of cells obtained from bone marrow aspirates. This technique may be a useful adjunct to flow cytometry and other methods when an extensive phenotype of the leukaemia cell is desired for clinical trials, research and prognostic factor analysis.
AbstractList A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell‐capture technique in which 82 antigens are studied simultaneously. This paper presents the analysis of 733 patients with a variety of leukaemias and lymphomas from peripheral blood and bone marrow. Discriminant Function Analysis of the expression profiles from these 733 patients and 63 normal subjects were clustered and showed high levels of consistency with diagnoses obtained using conventional clinical and laboratory criteria. The overall levels of consensus for classification using the microarray compared with established criteria were 93·9% (495/527 patients) for peripheral blood and 97·6% (201/206 patients) for bone marrow aspirates, showing that the extensive phenotype alone was frequently able to classify the disease when the leukaemic clone was the dominant cell population present. Immunophenotypes for neoplastic cells were distinguishable from normal cells when the leukaemic cell count was at least 5 × 10 9  cells/l in peripheral blood, or 20% of cells obtained from bone marrow aspirates. This technique may be a useful adjunct to flow cytometry and other methods when an extensive phenotype of the leukaemia cell is desired for clinical trials, research and prognostic factor analysis.
A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell-capture technique in which 82 antigens are studied simultaneously. This paper presents the analysis of 733 patients with a variety of leukaemias and lymphomas from peripheral blood and bone marrow. Discriminant Function Analysis of the expression profiles from these 733 patients and 63 normal subjects were clustered and showed high levels of consistency with diagnoses obtained using conventional clinical and laboratory criteria. The overall levels of consensus for classification using the microarray compared with established criteria were 93.9% (495/527 patients) for peripheral blood and 97.6% (201/206 patients) for bone marrow aspirates, showing that the extensive phenotype alone was frequently able to classify the disease when the leukaemic clone was the dominant cell population present. Immunophenotypes for neoplastic cells were distinguishable from normal cells when the leukaemic cell count was at least 5 x 10(9) cells/l in peripheral blood, or 20% of cells obtained from bone marrow aspirates. This technique may be a useful adjunct to flow cytometry and other methods when an extensive phenotype of the leukaemia cell is desired for clinical trials, research and prognostic factor analysis.
Summary A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell‐capture technique in which 82 antigens are studied simultaneously. This paper presents the analysis of 733 patients with a variety of leukaemias and lymphomas from peripheral blood and bone marrow. Discriminant Function Analysis of the expression profiles from these 733 patients and 63 normal subjects were clustered and showed high levels of consistency with diagnoses obtained using conventional clinical and laboratory criteria. The overall levels of consensus for classification using the microarray compared with established criteria were 93·9% (495/527 patients) for peripheral blood and 97·6% (201/206 patients) for bone marrow aspirates, showing that the extensive phenotype alone was frequently able to classify the disease when the leukaemic clone was the dominant cell population present. Immunophenotypes for neoplastic cells were distinguishable from normal cells when the leukaemic cell count was at least 5 × 109 cells/l in peripheral blood, or 20% of cells obtained from bone marrow aspirates. This technique may be a useful adjunct to flow cytometry and other methods when an extensive phenotype of the leukaemia cell is desired for clinical trials, research and prognostic factor analysis.
Author Green, Anthony R.
Belov, Larissa
Christopherson, Richard I.
Barber, Nicole
Mulligan, Stephen P.
Stoner, Kerryn
Young, Graham A.R.
Wierda, William G.
Pascovici, Dana S.
Thomas, Mervyn
Scott, Mike
Wiley, James S.
Keating, Michael J.
Woolfson, Adrian
Bendall, Linda
Bradstock, Kenneth F.
Erber, Wendy
Juneja, Surender
Sewell, William A.
Sartor, Mary
Chrisp, Jeremy S.
Huang, Pauline
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Issue 2
Keywords Human
Hematology
Immunophenotype
Antibody
Leukemia
DNA chip
Malignant hemopathy
Lymphoid neoplasm
Lymphoma
Antigen
CD antigens
array
Lymphoproliferative syndrome
leukaemia
expression profile
Language English
License CC BY 4.0
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PublicationTitle British journal of haematology
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Snippet Summary A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell‐capture...
A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell-capture technique...
A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell‐capture technique...
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SubjectTerms Acute Disease
Antigens, CD - blood
Antigens, Neoplasm - blood
array
Biological and medical sciences
Bone Marrow - immunology
CD antigens
Diagnosis, Differential
expression profile
Flow Cytometry
Hematologic and hematopoietic diseases
Humans
immunophenotype
Immunophenotyping - methods
leukaemia
Leukemia - classification
Leukemia - diagnosis
Leukemia - immunology
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma - classification
Lymphoma - diagnosis
Lymphoma - immunology
Lymphoma, B-Cell - classification
Lymphoma, B-Cell - diagnosis
Lymphoma, B-Cell - immunology
Medical sciences
Protein Array Analysis - methods
Title Analysis of human leukaemias and lymphomas using extensive immunophenotypes from an antibody microarray
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2141.2006.06266.x
https://www.ncbi.nlm.nih.gov/pubmed/16939496
https://search.proquest.com/docview/68909899
Volume 135
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